Isolation of Cache Valley virus and detection of antibody for selected arboviruses in Michigan horses in 1980.
Abstract: Blood samples collected in September and November 1980 from 87 horses in southwestern Michigan were examined for virus isolation and for plaque-reduction neutralizing antibody against selected arboviruses. Cache Valley virus was isolated from the blood of a clinically normal horse in St Joseph County in September. The age-specific antibody prevalence for Cache Valley virus indicated enzootic transmission in the study area. The high antibody prevalence and the lack of age-specific antibody prevalence indicated sporadic, but intense, exposure to Jamestown Canyon virus. Low prevalences of antibody were detected for Highlands J, snowshoe hare, St Louis encephalitis, and trivittatus viruses.
Publication Date: 1987-07-01 PubMed ID: 3631684
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- Journal Article
Summary
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The research article explores the discovery and study of the Cache Valley virus in Michigan horses in 1980. It also investigates the presence of antibodies for certain arboviruses in these horses.
Objective and Methodology of the Study
- The purpose of the study was to determine the presence of the Cache Valley virus and other selected arboviruses in horses in south-western Michigan. The researchers collected blood samples from 87 horses in September and November of 1980.
- The scientists employed virus isolation and plaque-reduction neutralizing antibody testing on the samples. These techniques are commonly used in virology to identify the presence and measure the quantity or concentration of viruses in the study samples.
Findings of the Study
- The researchers were able to isolate the Cache Valley virus from the blood of a horse showing no clinical symptoms. This horse was located in St Joseph County in September.
- The study revealed a high prevalence of antibodies against the Cache Valley virus, suggesting an enzootic or endemic transmission within the study area. Enzootic transmission refers to the consistent presence or regular spreading of a disease within a particular animal population in a specific geographical region.
- There was also a high prevalence of antibodies observed against the Jamestown Canyon virus, but the lack of age-specific antibody prevalence pointed towards sporadic yet intense exposure to this virus. This suggests that while the exposure to this virus was not continuous, it was quite intense during the periods when it occurred.
- Lower prevalences of antibodies were detected for Highlands J, snowshoe hare, St Louis encephalitis, and trivittatus viruses. The lower prevalence could signify that these viruses were not as widely spread or as active as the Cache Valley and Jamestown Canyon viruses among the tested horse population during the study period.
Significance of the Study
- This study provides important insights about the prevalence and transmission of the Cache Valley virus and selected arboviruses among horses in southwest Michigan. These findings may help in early diagnosis and prevention of these viruses among horse populations.
- The results also contribute to the existing knowledge on horse diseases and their transmission patterns, which is critical in formulating effective strategies for disease control and prevention.
Cite This Article
APA
McLean RG, Calisher CH, Parham GL.
(1987).
Isolation of Cache Valley virus and detection of antibody for selected arboviruses in Michigan horses in 1980.
Am J Vet Res, 48(7), 1039-1041.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antibodies, Viral / analysis
- Bunyamwera virus / immunology
- Bunyamwera virus / isolation & purification
- Bunyaviridae / isolation & purification
- Encephalitis Virus, California / immunology
- Encephalitis Virus, Eastern Equine / immunology
- Encephalitis Virus, St. Louis / immunology
- Encephalitis Virus, Western Equine / immunology
- Horses / microbiology
- Michigan
Citations
This article has been cited 12 times.- López K, Wilson SN, Coutermash-Ott S, Tanelus M, Stone WB, Porier DL, Auguste DI, Muller JA, Allicock OM, Paulson SL, Erasmus JH, Auguste AJ. Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission.. Emerg Microbes Infect 2021 Dec;10(1):1649-1659.
- Waddell L, Pachal N, Mascarenhas M, Greig J, Harding S, Young I, Wilhelm B. Cache Valley virus: A scoping review of the global evidence.. Zoonoses Public Health 2019 Nov;66(7):739-758.
- Ayers VB, Huang YS, Lyons AC, Park SL, Higgs S, Dunlop JI, Kohl A, Alto BW, Unlu I, Blitvich BJ, Vanlandingham DL. Culex tarsalis is a competent vector species for Cache Valley virus.. Parasit Vectors 2018 Sep 20;11(1):519.
- Uehlinger FD, Wilkins W, Godson DL, Drebot MA. Seroprevalence of Cache Valley virus and related viruses in sheep and other livestock from Saskatchewan, Canada.. Can Vet J 2018 Apr;59(4):413-418.
- Andreadis TG, Armstrong PM, Anderson JF, Main AJ. Spatial-temporal analysis of Cache Valley virus (Bunyaviridae: Orthobunyavirus) infection in anopheline and culicine mosquitoes (Diptera: Culicidae) in the northeastern United States, 1997-2012.. Vector Borne Zoonotic Dis 2014 Oct;14(10):763-73.
- Nguyen NL, Zhao G, Hull R, Shelly MA, Wong SJ, Wu G, St George K, Wang D, Menegus MA. Cache valley virus in a patient diagnosed with aseptic meningitis.. J Clin Microbiol 2013 Jun;51(6):1966-9.
- Blitvich BJ, Saiyasombat R, Travassos da Rosa A, Tesh RB, Calisher CH, Garcia-Rejon JE, Farfán-Ale JA, Loroño RE, Bates A, Loroño-Pino MA. Orthobunyaviruses, a common cause of infection of livestock in the Yucatan peninsula of Mexico.. Am J Trop Med Hyg 2012 Dec;87(6):1132-9.
- Blitvich BJ, Loroño-Pino MA, Garcia-Rejon JE, Farfan-Ale JA, Dorman KS. Nucleotide sequencing and serologic analysis of Cache Valley virus isolates from the Yucatan Peninsula of Mexico.. Virus Genes 2012 Aug;45(1):176-80.
- Rodrigues Hoffmann A, Welsh CJ, Wilcox Varner P, de la Concha-Bermejillo A, Marchand Ball J, Ambrus A, Edwards JF. Identification of the target cells and sequence of infection during experimental infection of ovine fetuses with Cache Valley virus.. J Virol 2012 May;86(9):4793-800.
- Wang H, Nattanmai S, Kramer LD, Bernard KA, Tavakoli NP. A duplex real-time reverse transcriptase polymerase chain reaction assay for the detection of California serogroup and Cache Valley viruses.. Diagn Microbiol Infect Dis 2009 Oct;65(2):150-7.
- Campbell GL, Mataczynski JD, Reisdorf ES, Powell JW, Martin DA, Lambert AJ, Haupt TE, Davis JP, Lanciotti RS. Second human case of Cache Valley virus disease.. Emerg Infect Dis 2006 May;12(5):854-6.
- Soldan SS, González-Scarano F. Emerging infectious diseases: the Bunyaviridae.. J Neurovirol 2005 Oct;11(5):412-23.
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