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Isolation of equine herpesvirus type 1 from a horse with an acute paralytic disease.

Abstract: A Standardbred mare became paralyzed shortly after showing signs of an upper respiratory infection. The mare was euthanized and equine herpesvirus type 1 was isolated from the brain and spinal cord.
Publication Date: 1975-07-01 PubMed ID: 166741PubMed Central: PMC1277473
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study involves a horse that showed signs of upper respiratory infection and later became paralyzed. The researchers discovered that the animal was infected with equine herpesvirus type 1, which was isolated from the brain and spinal cord following the horse’s euthanization.

Introduction

  • The research article investigates a health issue that arose in a Standardbred mare, characterized by a sudden paralytic condition after the exhibition of upper respiratory infection symptoms.

Health Issue and Procedure

  • The horse fell ill, initially demonstrating symptoms consistent with an upper respiratory infection. Within a short period, however, the animal developed paralysis and further deteriorated rapidly, prompting its euthanization by the team.
  • No specific details regarding the time elapsed between the emergence of the respiratory infection symptoms and the onset of the paralysis are mentioned in the abstract. It is also not clear the severity of the respiratory infection before the sudden onset of paralysis.

Virus Identification

  • Postmortem studies were performed on the mare. These studies led to the discovery of an infection with equine herpesvirus type 1. The virus was isolated from the brain and spinal cord of the euthanized animal. This implies that there was a neurological invasion by the virus, likely leading to the paralytic state.
  • The equine herpesvirus type 1 is a common virus within the equine community. It often causes respiratory disease but has also been associated with neurological disease, which likely resulted in the paralysis experienced by the horse in this study.

Importance of the Study

  • This case study is important as it demonstrates the rapid progressive effect of equine herpesvirus type 1. Not typically associated with extreme outcomes like paralysis, this case highlights the potential severity of this common equine infection.
  • In essence, the research lets veterinary professionals to be on the lookout for severe neurological symptoms in horses displaying signs of upper respiratory infection, and consider equine herpesvirus type 1 in their differential diagnosis.

Cite This Article

APA
Thorsen J, Little PB. (1975). Isolation of equine herpesvirus type 1 from a horse with an acute paralytic disease. Can J Comp Med, 39(3), 358-359.

Publication

ISSN: 0008-4050
NlmUniqueID: 0151747
Country: Canada
Language: English
Volume: 39
Issue: 3
Pages: 358-359

Researcher Affiliations

Thorsen, J
    Little, P B

      MeSH Terms

      • Animals
      • Antibodies, Viral / analysis
      • Brain / microbiology
      • Cells, Cultured
      • Central Nervous System Diseases / microbiology
      • Central Nervous System Diseases / veterinary
      • Herpesviridae / isolation & purification
      • Herpesviridae Infections / veterinary
      • Herpesvirus 1, Equid / isolation & purification
      • Histological Techniques
      • Horse Diseases / microbiology
      • Horses
      • Paralysis / microbiology
      • Paralysis / veterinary
      • Spinal Cord / microbiology

      References

      This article includes 3 references
      1. Bitsch V, Dam A. Nervous disturbances in horses in relation to infection with equine rhinopneumonitis virus.. Acta Vet Scand 1971;12(1):134-6.
        pubmed: 4324962
      2. Jackson T, Kendrick JW. Paralysis of horses associated with equine herpesvirus 1 infection.. J Am Vet Med Assoc 1971 Apr 15;158(8):1351-7.
        pubmed: 4328999
      3. Petzoldt K, Luttmann U, Pohlenz J, Teichert U. [Virological studies of the central nervous system of horse fetuses and findings in mares suffering from central nervous system disease following abortion caused by equine herpesvirus 1].. Schweiz Arch Tierheilkd 1972 Feb;114(2):129-39.
        pubmed: 4334255

      Citations

      This article has been cited 4 times.
      1. Keane DP, Little PB. Equine viral encephalomyelitis in Canada: a review of known and potential causes. Can Vet J 1987 Aug;28(8):497-504.
        pubmed: 17422841
      2. Keane DP, Little PB, Wilkie BN, Artsob H, Thorsen J. Agents of equine viral encephalomyelitis: correlation of serum and cerebrospinal fluid antibodies. Can J Vet Res 1988 Apr;52(2):229-35.
        pubmed: 2836046
      3. Thomson GW, McCready R, Sanford E, Gagnon A. Case report: An outbreak of herpesvirus myeloencephalitis in vaccinated horses. Can Vet J 1979 Jan;20(1):22-5.
        pubmed: 216473
      4. Nishimura F, Fukushi N, Sakai H, Fukushi H. Attenuation of the neuropathogenic equine herpesvirus type 1 strain Ab4p in hamsters by a single amino acid mutation (D752N) in viral DNA polymerase ORF30. J Vet Med Sci 2024 Dec 1;86(12):1273-1278.
        doi: 10.1292/jvms.24-0338pubmed: 39384384google scholar: lookup