Ivermectin: a potent new antiparasitic agent.
Abstract: Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by gamma-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine.
Publication Date: 1983-08-26 PubMed ID: 6308762DOI: 10.1126/science.6308762Google Scholar: Lookup
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Summary
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The research paper is about Ivermectin, a new, potent antiparasitic drug derived from actinomycete Streptomyces avermitilis, which has shown high effectiveness against a wide range of parasites in livestock, with potential applications in human medicine yet to be determined.
Introduction to Ivermectin
- Ivermectin is the 22,23-dihydro derivative of avermectin B1, which is a macrocyclic lactone. It is produced by an actinomycete, a type of microorganism, known as Streptomyces avermitilis.
- The drug has demonstrated potent antiparasitic properties, being extremely effective at low doses against a variety of nematode and arthropod parasites.
Mechanism of Action
- The effectiveness of Ivermectin appears to be linked to its ability to mediate neurotransmission by gamma-aminobutyric acid (GABA).
- GABA is a neurotransmitter that, among other functions, inhibits the activity of nerve cells. By enhancing GABA activity, Ivermectin causes paralysis and death in parasites that are sensitive to this neurotransmitter.
Current Applications
- Ivermectin is already commercially available and is used in various countries for treating and controlling parasites in livestock such as cattle, horses, and sheep.
- The drug also has potential for use against parasites in other animals such as swine and dogs.
Future Applications in Human Medicine
- At the time the research paper was written, studies of Ivermectin’s application in human medicine were still in a preliminary stage, so it was unclear whether the drug would prove useful in this domain.
- Future research may confirm the drug’s safety and efficacy in treating parasitic infections in humans, potentially extending its application to this area of medical treatment.
Cite This Article
APA
Campbell WC, Fisher MH, Stapley EO, Albers-Schönberg G, Jacob TA.
(1983).
Ivermectin: a potent new antiparasitic agent.
Science, 221(4613), 823-828.
https://doi.org/10.1126/science.6308762 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Anthelmintics
- Arthropods / drug effects
- Humans
- Insecticides / therapeutic use
- Ivermectin
- Lactones / metabolism
- Lactones / pharmacology
- Lactones / therapeutic use
- Nematode Infections / drug therapy
- Streptomyces / physiology
- Structure-Activity Relationship
- Synaptic Transmission / drug effects
Citations
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