Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals.
Abstract: The hypothalamo-pituitary-gonadal (HPG) axis is the regulatory system for reproduction in mammals. Because secretion of gonadotropin-releasing hormone (GnRH) into the portal vessels is the final step at which the brain controls gonadal activities, the GnRH neuronal system had been thought to be central to the HPG axis. A newly discovered neural peptide, kisspeptin, has opened a new era in reproductive neuroendocrinology. As shown in a variety of mammals, kisspeptin is a potent endogenous secretagogue of GnRH, and the kisspeptin neuronal system governs both the pulsatile GnRH secretion that drives folliculogenesis, spermatogenesis and steroidogenesis, and the GnRH surge that triggers ovulation in females. The kisspeptin neuronal system is therefore considered a master player in the central control of mammalian reproduction, and kisspeptin and related substances could therefore be valuable for the development of novel strategies for the management of fertility in farm animals. To this end, the present review aimed to summarize the current research on kisspeptin signaling with a focus on domestic animals such as sheep, goats, cattle, pigs and horses.
© 2013 Japanese Society of Animal Science.
Publication Date: 2013-03-27 PubMed ID: 23607315DOI: 10.1111/asj.12056Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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The research article discusses the important role of kisspeptin, a neural peptide, in the reproductive system of mammals, specifically in domestic animals. It provides an overview of studies focusing on the impact of kisspeptin on the hypothalamo-pituitary-gonadal (HPG) axis, which is crucial for reproduction.
Role of Kisspeptin in Reproduction
- The key subject of the research is a neural peptide, kisspeptin, that has emerged as an essential factor in reproductive neuroendocrinology. Kisspeptin has been proven to act as a potent endogenous secretagogue (a substance that promotes secretion) of gonadotropin-releasing hormone (GnRH), which is the final step of brain control in gonadal activities.
- The paper explains that kisspeptin governs the pulsatile (rhythmical) secretion of GnRH, which is essential for the processes of folliculogenesis (the process by which ovarian follicles mature), spermatogenesis (the process by which sperm cells are produced), and steroidogenesis (the production of steroids, a type of organic compound).
- The researchers also highlight that the kisspeptin neural system influences the sudden GnRH surge that leads to ovulation in females. Given these significant roles in reproductive processes, kisspeptin is considered a master player in the central control of mammalian reproduction.
Kisspeptin Research in Domestic Animals
- The paper additionally focuses on the potential value of kisspeptin and other related substances in managing fertility in domestic animals. With the capabilities of kisspeptin to control crucial aspects of reproduction, it could be used to develop innovative strategies in fertility control of farm animals.
- To provide context and support this potential, the paper reviews current studies on kisspeptin signaling in domestic animals such as sheep, goats, cattle, pigs, and horses.
- It aims to compile the existing research on kisspeptin’s role and potential in fertility management, thus providing a comprehensive understanding that can steer future research and developments in the field.
Cite This Article
APA
Okamura H, Yamamura T, Wakabayashi Y.
(2013).
Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals.
Anim Sci J, 84(5), 369-381.
https://doi.org/10.1111/asj.12056 Publication
Researcher Affiliations
- Animal Physiology Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan.
- Animal Physiology Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan.
- Animal Physiology Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan.
MeSH Terms
- Animals
- Animals, Domestic / physiology
- Gonadotropin-Releasing Hormone / metabolism
- Gonadotropin-Releasing Hormone / physiology
- Gonads / physiology
- Humans
- Hypothalamo-Hypophyseal System / physiology
- Kisspeptins / administration & dosage
- Kisspeptins / pharmacology
- Kisspeptins / physiology
- Male
- Neurosecretory Systems / physiology
- Pituitary-Adrenal System / physiology
- Reproduction / genetics
- Reproduction / physiology
- Stimulation, Chemical
Citations
This article has been cited 17 times.- Nestor CC, Merkley CM, Lehman MN, Hileman SM, Goodman RL. KNDy neurons as the GnRH pulse generator: Recent studies in ruminants.. Peptides 2023 Jun;164:171005.
- Rabouti H, Asghari SM, Sariri R, Balalaie S, Valipour A, Omidian N, Heidari B. Functional evaluation of a novel kisspeptin analogue on the reproduction of female goldfish.. Sci Rep 2022 Dec 19;12(1):21944.
- Goodman RL, Herbison AE, Lehman MN, Navarro VM. Neuroendocrine control of gonadotropin-releasing hormone: Pulsatile and surge modes of secretion.. J Neuroendocrinol 2022 May;34(5):e13094.
- Rehman SU, Hassan FU, Luo X, Li Z, Liu Q. Whole-Genome Sequencing and Characterization of Buffalo Genetic Resources: Recent Advances and Future Challenges.. Animals (Basel) 2021 Mar 22;11(3).
- Archunan G. Reproductive enhancement in buffalo: looking at urinary pheromones and hormones.. Iran J Vet Res 2020 Summer;21(3):163-171.
- Oshimo Y, Munetomo A, Magata F, Suetomi Y, Sonoda S, Takeuchi Y, Tsukamura H, Ohkura S, Matsuda F. Estrogen increases KISS1 expression in newly generated immortalized KISS1-expressing cell line derived from goat preoptic area.. J Reprod Dev 2021 Feb 15;67(1):15-23.
- D'Occhio MJ, Campanile G, Baruselli PS. Peripheral action of kisspeptin at reproductive tissues-role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review.. Biol Reprod 2020 Dec 1;103(6):1157-1170.
- Kwong GPS, Klein C. Deslorelin and naltrexone stimulate follicular development in mares during autumn transition and early anestrus.. Can Vet J 2019 Aug;60(8):855-858.
- Pottapenjera V, Rajanala SR, Reddy C, Gangineni A, Avula K, Bejjanki SK, Sathagopam S, Kesharwani S, Velmurugan S. Kisspeptin Modulates Luteinizing Hormone Release and Ovarian Follicular Dynamics in Pre-pubertal and Adult Murrah Buffaloes.. Front Vet Sci 2018;5:149.
- Okamura H, Yamamura T, Wakabayashi Y. Mapping of KNDy neurons and immunohistochemical analysis of the interaction between KNDy and substance P neural systems in goat.. J Reprod Dev 2017 Dec 15;63(6):571-580.
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- Endo N, Tanaka T. Effects of senktide, a neurokinin 3 receptor agonist, on luteinizing hormone secretion and follicular development in anestrous Shiba goats: a pilot study.. BMC Res Notes 2014 Nov 3;7:773.
- Yamamura T, Wakabayashi Y, Ohkura S, Navarro VM, Okamura H. Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats.. J Reprod Dev 2015;61(1):20-9.
- Usuda K, Nagaoka K, Nozawa K, Zhang H, Taya K, Yoshida M, Watanabe G. Neonatal exposure to 17α-ethinyl estradiol affects kisspeptin expression and LH-surge level in female rats.. J Vet Med Sci 2014 Aug;76(8):1105-10.
- Pasquier J, Lafont AG, Rousseau K, Quérat B, Chemineau P, Dufour S. Looking for the bird Kiss: evolutionary scenario in sauropsids.. BMC Evol Biol 2014 Feb 19;14(1):30.
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