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Home / Equine Research Bank / J Musculoskelet Neuronal Interact / Krogh’s principle for musculoskeletal physiology and p...
Journal of musculoskeletal & neuronal interactions2018; 18(3); 284-291;

Krogh’s principle for musculoskeletal physiology and pathology.

Abstract: August Krogh was a comparative physiologist who used frogs, guinea pigs, cats, dogs, and horses in his research that led to his Nobel Prize on muscle physiology. His idea to choose the most relevant organism to study problems in physiology has become known as Krogh's principle. Indeed, many important discoveries in physiology have been made using naturally occurring animal models. However, the majority of research today utilizes laboratory mouse and rat models to study problems in physiology. This paper discusses how Krogh's principle can be invoked in musculoskeletal research as a complementary approach to using standard laboratory rodent models for solving problems in musculoskeletal physiology. This approach may increase our ability to treat musculoskeletal diseases clinically. For example, it has been noted that progress in osteogenesis imperfecta research has been limited by the absence of a naturally occurring animal model. Several examples of naturally occurring animal models are discussed including osteoarthritis and osteosarcoma in dogs, resistance to disuse induced bone and skeletal muscle loss in mammalian hibernators, and bone phenotypic plasticity in fish lacking osteocytes. Many musculoskeletal diseases (e.g., osteoarthritis) occur naturally in companion animals, which may provide clues on etiology and progression of musculoskeletal diseases and accelerate the development of pharmaceutical therapies for humans.
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Publication Date: 2018-09-05 PubMed ID: 30179205PubMed Central: PMC6146200
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores the application of Krogh’s principle – the choice of the most suitable organism for the study of a particular physiological issue – in the field of musculoskeletal research. The authors discuss how this approach can complement the prevailing use of lab rodents and potentially enhance the process of discovering treatment for musculoskeletal diseases.

Understanding Krogh’s Principle

  • The principle was established by August Krogh, a notable comparative physiologist, known for his work involving a variety of animals including cats, dogs, and horses.
  • The principle suggests that for every physiological problem, there is an organism best suited to its study. The objective is to choose the most relevant organism to study specific problems in physiology.
  • Over the years, Krogh’s principle has facilitated several important discoveries in the realm of physiology, specifically through the use of naturally occurring animal models.

Application in Musculoskeletal Physiology and Pathology

  • The paper propositions how Krogh’s principle can be leveraged in musculoskeletal research, offering a fresh approach to using standardized lab rodent models for solving problems in musculoskeletal physiology.
  • This innovative approach could potentially amplify our capacity for discovering clinical treatments for various musculoskeletal diseases.

Naturally Occurring Animal Models and Disease Study

  • The authors refer to the limited progress in research on Osteogenesis Imperfecta due to the lack of a naturally occurring animal model. This reference demonstrates the importance of using the right organism in understanding specific health conditions.
  • Examples of naturally occurring animal models for musculoskeletal issues include the occurrence of osteoarthritis and osteosarcoma in dogs, mammalian hibernators’ resistance to disuse-induced bone and skeletal muscle loss, and bone phenotypic plasticity in osteocyte-lacking fish.
  • These models emphasize that many musculoskeletal diseases that humans suffer from (such as osteoarthritis) also occur naturally in animals. Studying these cases can provide crucial insights into the origin and progression of musculoskeletal diseases and can fast-track the development of pharmaceutical therapies for human patients.

Cite This Article

APA
Donahue SW. (2018). Krogh’s principle for musculoskeletal physiology and pathology. J Musculoskelet Neuronal Interact, 18(3), 284-291.

Publication

Journal of musculoskeletal & neuronal interactions
ISSN: 1108-7161
NlmUniqueID: 101084496
Country: Greece
Language: English
Volume: 18
Issue: 3
Pages: 284-291

Researcher Affiliations

Donahue, Seth W
  • Department of Biomedical Engineering, University of Massachusetts, USA.

MeSH Terms

  • Adaptation, Physiological / physiology
  • Animals
  • Bone and Bones / physiology
  • Cartilage, Articular / physiology
  • Muscle, Skeletal / physiology
  • Musculoskeletal Physiological Phenomena

Conflict of Interest Statement

The authors have no conflict of interest.

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Citations

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