FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Can Vet J / Lack of antibodies to porcine circovirus type 2 virus in bee...
The Canadian veterinary journal = La revue veterinaire canadienne2001; 42(6); 461-464;

Lack of antibodies to porcine circovirus type 2 virus in beef and dairy cattle and horses in western Canada.

Abstract: Porcine circovirus type 2 (PCV2) is a recently recognized agent that is consistently associated with postweaning multisystemic wasting disease in swine. There are conflicting data concerning the ability of this virus to infect and cause disease in other species. To determine if normal cattle, cattle affected with various illnesses, and normal horses in endemic areas of PCV2 infection in swine have had PCV2 infections, 100 randomly selected bovine sera, 100 equine sera, and 100 colostrum samples from clinically normal dairy cattle were examined for the presence of antibodies to porcine circoviruses by using ELISAs. All samples tested were negative for antibodies to porcine circoviruses. As well, a seronegative neonatal Holstein calf and 6 seronegative, 6-month-old beef calves that were experimentally infected with PCV2 failed to develop antibodies to the virus. These results suggest that natural infection of cattle and horses with PCV2 does not occur, or is a rare event, in western Canada.
Get Full Text
Publication Date: 2001-06-27 PubMed ID: 11424578PubMed Central: PMC1476552
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates if Porcine circovirus type 2 (PCV2), a virus commonly associated with disease in swine, infects cattle and horses in western Canada. The study found no presence of PCV2 antibodies in the tested samples.

Objective

The objective of the research was to determine whether cattle (both normal and those affected with various illnesses) and horses in areas where PCV2 infection in pigs is commonly found have been infected by PCV2.

Methodology

  • The study examined a variety of samples to trace any sign of PCV2 infection:
  • A total of 100 bovine sera samples (randomly selected) were tested to see if they had contracted the virus.
  • Another 100 equine sera samples were also tested for the presence of PCV2.
  • Additionally, 100 colostrum (a type of milk produced by the mammary glands of mammals after giving birth) samples from clinically normal dairy cows were examined as well.
  • Experiments were performed involving a seronegative (one with no detectable antibodies) new born Holstein calf and six seronegative beef calves that were about 6 months old, who were infected with PCV2 to see if they developed antibodies to the virus.
  • All tests were performed using a type of test known as Enzyme-Linked Immunosorbent Assays (ELISAs), which identifies any antibodies that the body might have produced in response to the virus.

Results

  • None of the samples, including bovine sera, equine sera, and colostrum samples from dairy cows, had antibodies to porcine circoviruses, indicating a lack of PCV2 infection.
  • Similarly, the childless and beef calves that were experimentally infected with PCV2 also failed to generate antibodies against the virus.

Conclusion

The study concluded that natural infection by PCV2 in cattle and horses either does not occur or is a rare event in the region of western Canada. This provides valuable insight for the livestock industry and veterinary care providers in the region concerning the spread of PCV2.

Cite This Article

APA
Ellis JA, Konoby C, West KH, Allan GM, Krakowka S, McNeilly F, Meehan B, Walker I. (2001). Lack of antibodies to porcine circovirus type 2 virus in beef and dairy cattle and horses in western Canada. Can Vet J, 42(6), 461-464.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 42
Issue: 6
Pages: 461-464

Researcher Affiliations

Ellis, J A
  • Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
Konoby, C
    West, K H
      Allan, G M
        Krakowka, S
          McNeilly, F
            Meehan, B
              Walker, I

                MeSH Terms

                • Animals
                • Antibodies, Viral / analysis
                • Cattle
                • Cattle Diseases / epidemiology
                • Cattle Diseases / immunology
                • Cattle Diseases / virology
                • Circoviridae Infections / epidemiology
                • Circoviridae Infections / immunology
                • Circoviridae Infections / veterinary
                • Circovirus / immunology
                • Circovirus / pathogenicity
                • Colostrum / immunology
                • Enzyme-Linked Immunosorbent Assay / methods
                • Enzyme-Linked Immunosorbent Assay / veterinary
                • Horse Diseases / epidemiology
                • Horse Diseases / immunology
                • Horse Diseases / virology
                • Horses

                References

                This article includes 17 references
                1. Allan GM, McNeilly F, McNair I, Curran MD, Walker I, Ellis J, Konoby C, Kennedy S, Meehan B. Absence of evidence for porcine circovirus type 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep.. Arch Virol 2000;145(4):853-7.
                  pubmed: 10893163doi: 10.1007/s007050050678google scholar: lookup
                2. Ellis J, Krakowka S, Lairmore M, Haines D, Bratanich A, Clark E, Allan G, Konoby C, Hassard L, Meehan B, Martin K, Harding J, Kennedy S, McNeilly F. Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets.. J Vet Diagn Invest 1999 Jan;11(1):3-14.
                  pubmed: 9925205doi: 10.1177/104063879901100101google scholar: lookup
                3. Meehan BM, McNeilly F, Todd D, Kennedy S, Jewhurst VA, Ellis JA, Hassard LE, Clark EG, Haines DM, Allan GM. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs.. J Gen Virol 1998 Sep;79 ( Pt 9):2171-9.
                  pubmed: 9747726doi: 10.1099/0022-1317-79-9-2171google scholar: lookup
                4. Allan G, Meehan B, Todd D, Kennedy S, McNeilly F, Ellis J, Clark EG, Harding J, Espuna E, Botner A, Charreyre C. Novel porcine circoviruses from pigs with wasting disease syndromes.. Vet Rec 1998 Apr 25;142(17):467-8.
                  pubmed: 9602519
                5. Allan GM, McNeilly F, Kennedy S, Daft B, Clarke EG, Ellis JA, Haines DM, Meehan BM, Adair BM. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe.. J Vet Diagn Invest 1998 Jan;10(1):3-10.
                  pubmed: 9526853doi: 10.1177/104063879801000102google scholar: lookup
                6. Ellis J, Hassard L, Clark E, Harding J, Allan G, Willson P, Strokappe J, Martin K, McNeilly F, Meehan B, Todd D, Haines D. Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome.. Can Vet J 1998 Jan;39(1):44-51.
                  pubmed: 9442952
                7. Segalés J, Sitjar M, Domingo M, Dee S, Del Pozo M, Noval R, Sacristan C, De las Heras A, Ferro A, Latimer KS. First report of post-weaning multisystemic wasting syndrome in pigs in Spain.. Vet Rec 1997 Dec 6;141(23):600-1.
                  pubmed: 9429277
                8. Tischer I, Bode L, Apodaca J, Timm H, Peters D, Rasch R, Pociuli S, Gerike E. Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle.. Arch Virol 1995;140(8):1427-39.
                  pubmed: 7544971doi: 10.1007/BF01322669google scholar: lookup
                9. Allan GM, Phenix KV, Todd D, McNulty MS. Some biological and physico-chemical properties of porcine circovirus.. Zentralbl Veterinarmed B 1994 Mar;41(1):17-26.
                  pubmed: 7941842doi: 10.1111/j.1439-0450.1994.tb00201.xgoogle scholar: lookup
                10. Tischer I, Gelderblom H, Vettermann W, Koch MA. A very small porcine virus with circular single-stranded DNA.. Nature 1982 Jan 7;295(5844):64-6.
                  pubmed: 7057875doi: 10.1038/295064a0google scholar: lookup
                11. Morozov I, Sirinarumitr T, Sorden SD, Halbur PG, Morgan MK, Yoon KJ, Paul PS. Detection of a novel strain of porcine circovirus in pigs with postweaning multisystemic wasting syndrome.. J Clin Microbiol 1998 Sep;36(9):2535-41.
                  pubmed: 9705388doi: 10.1128/JCM.36.9.2535-2541.1998google scholar: lookup
                12. Allan GM, Ellis JA. Porcine circoviruses: a review.. J Vet Diagn Invest 2000 Jan;12(1):3-14.
                  pubmed: 10690769doi: 10.1177/104063870001200102google scholar: lookup
                13. Choi C, Chae C, Clark EG. Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction.. J Vet Diagn Invest 2000 Mar;12(2):151-3.
                  pubmed: 10730945doi: 10.1177/104063870001200209google scholar: lookup
                14. Nayar GP, Hamel AL, Lin L, Sachvie C, Grudeski E, Spearman G. Evidence for circovirus in cattle with respiratory disease and from aborted bovine fetuses.. Can Vet J 1999 Apr;40(4):277-8.
                  pubmed: 10200889
                15. Walker IW, Konoby CA, Jewhurst VA, McNair I, McNeilly F, Meehan BM, Cottrell TS, Ellis JA, Allan GM. Development and application of a competitive enzyme-linked immunosorbent assay for the detection of serum antibodies to porcine circovirus type 2.. J Vet Diagn Invest 2000 Sep;12(5):400-5.
                  pubmed: 11021425doi: 10.1177/104063870001200502google scholar: lookup
                16. Ellis JA, Wiseman BM, Allan G, Konoby C, Krakowka S, Meehan BM, McNeilly F. Analysis of seroconversion to porcine circovirus 2 among veterinarians from the United States and Canada.. J Am Vet Med Assoc 2000 Dec 1;217(11):1645-6.
                  pubmed: 11110452doi: 10.2460/javma.2000.217.1645google scholar: lookup
                17. Krakowka S, Ellis JA, McNeilly F, Ringler S, Rings DM, Allan G. Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2).. Vet Pathol 2001 Jan;38(1):31-42.
                  pubmed: 11199162doi: 10.1354/vp.38-1-31google scholar: lookup

                Citations

                This article has been cited 8 times.
                1. Hui A, Altan E, Slovis N, Fletcher C, Deng X, Delwart E. Circovirus in Blood of a Febrile Horse with Hepatitis. Viruses 2021 May 20;13(5).
                  doi: 10.3390/v13050944pubmed: 34065502google scholar: lookup
                2. Du Q, Huang Y, Wang T, Zhang X, Chen Y, Cui B, Li D, Zhao X, Zhang W, Chang L, Tong D. Porcine circovirus type 2 activates PI3K/Akt and p38 MAPK pathways to promote interleukin-10 production in macrophages via Cap interaction of gC1qR. Oncotarget 2016 Apr 5;7(14):17492-507.
                  doi: 10.18632/oncotarget.7362pubmed: 26883107google scholar: lookup
                3. Zhai SL, Chen RA, Chen SN, Wen XH, Lv DH, Wu DC, Yuan J, Huang Z, Zhou XR, Luo ML, He DS, Wei WK. First molecular detection of porcine circovirus type 2 in bovids in China. Virus Genes 2014 Dec;49(3):507-11.
                  doi: 10.1007/s11262-014-1117-1pubmed: 25248785google scholar: lookup
                4. Burbelo PD, Ragheb JA, Kapoor A, Zhang Y. The serological evidence in humans supports a negligible risk of zoonotic infection from porcine circovirus type 2. Biologicals 2013 Nov;41(6):430-4.
                  doi: 10.1016/j.biologicals.2013.09.005pubmed: 24120888google scholar: lookup
                5. Wernike K, Hoffmann B, Beer M. Single-tube multiplexed molecular detection of endemic porcine viruses in combination with background screening for transboundary diseases. J Clin Microbiol 2013 Mar;51(3):938-44.
                  doi: 10.1128/JCM.02947-12pubmed: 23303496google scholar: lookup
                6. Delwart E, Li L. Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes. Virus Res 2012 Mar;164(1-2):114-21.
                  doi: 10.1016/j.virusres.2011.11.021pubmed: 22155583google scholar: lookup
                7. Li L, Kapoor A, Slikas B, Bamidele OS, Wang C, Shaukat S, Masroor MA, Wilson ML, Ndjango JB, Peeters M, Gross-Camp ND, Muller MN, Hahn BH, Wolfe ND, Triki H, Bartkus J, Zaidi SZ, Delwart E. Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces. J Virol 2010 Feb;84(4):1674-82.
                  doi: 10.1128/JVI.02109-09pubmed: 20007276google scholar: lookup
                8. Merten OW. Virus contaminations of cell cultures - A biotechnological view. Cytotechnology 2002 Jul;39(2):91-116.
                  doi: 10.1023/A:1022969101804pubmed: 19003296google scholar: lookup
                Subscribe to our newsletter
                Join 99,034 horse owners like you who receive our email updates on horse health and nutrition.