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Home / Equine Research Bank / Vet Parasitol / Lack of Cyathostomin sp. reduction after anthelmintic treatm...
Veterinary parasitology2012; 194(1); 35-39; doi: 10.1016/j.vetpar.2012.12.020

Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil.

Abstract: The increase of anthelmintic resistance in the last years in the nematode population of veterinary importance has become a major concern. The objective of the present study was to evaluate the efficacy of the main anthelmintic drugs available in the market against small strongyles of horses in Brazil. A total of 498 horses from 11 horse farms, located in the states of Paraná, São Paulo, Rio de Janeiro and Minas Gerais, in Brazil, were treated with ivermectin, moxidectin, pyrantel and fenbendazole, orally at their recommended doses. The fecal egg count reduction test (FECRT) was used to determine the product's efficacy and fecal culture was used to determine the parasite genus. Reduction on anthelmintic efficacy was found for fenbendazole in all horse farms (11/11), pyrantel in five yards (5/11) and ivermectin had low efficacy in one of the yards studied (1/11). Multidrug resistance of up to 3 drugs classes was found in one of the tested farms (1/11). Cyathostomin were the most prevalent parasite. The results showed that resistance to fenbendazole is widespread; the efficacy of pyrantel is in a critical situation. Although the macrocyclic lactones compounds still showed high efficacy on most farms, suspected resistance to macrocyclic lactones is of great concern.
Copyright © 2012 Elsevier B.V. All rights reserved.
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Publication Date: 2012-12-20 PubMed ID: 23318166DOI: 10.1016/j.vetpar.2012.12.020Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study focuses on assessing anthelmintic drug effectiveness against small strongyles, a type of parasitic nematode, in horses across various farms in Brazil. It found that resistance to these drugs is growing, with fenbendazole proving ineffective across all tested horse farms and multidrug resistance observed in one.

Study Objective and Methodology

  • The aim of this research was to evaluate the performance of widely-used anthelmintic drugs against small strongyles in horses in Brazil. Small strongyles are a nematode species of considerable importance in veterinary medicine.
  • The authors tested the drugs on a total of 498 horses, sourced from 11 farms located in different states across Brazil. The drugs tested include common anthelmintics like ivermectin, moxidectin, pyrantel and fenbendazole, all administered orally at recommended doses.
  • The research utilized the fecal egg count reduction test (FECRT) to assess the effectiveness of the drugs. Alongside this, fecal cultures were analyzed to determine the parasitic genus present.

Key Findings

  • Results demonstrated a decrease in anthelmintic efficacy across the board. Fenbendazole showed no efficacy on any of the studied horse farms (11/11). Pyrantel seemed ineffective in five of the farms (5/11) and ivermectin had low performance in one of the studied yards (1/11).
  • Alarmingly, the study also discovered multidrug resistance – to a maximum of three drug classes – in one of the tested farms (1/11). This indicates that some horses were resistant to multiple anthelmintic drugs.
  • The most prevalent parasite found was Cyathostomin, suggesting this species is the most resistant to the tested anthelmintic drugs.

Conclusions and Implications

  • The study concludes that resistance to the drug fenbendazole is widely spread amongst the horse farms in Brazil. The efficacy of pyrantel is also reaching a critical level.
  • Despite the majority of farms still showing high efficacy to macrocyclic lactones like ivermectin and moxidectin, the suspected resistance to these is a growing concern. If these drugs also lose their efficacy, it could pose significant treatment challenges for parasitic infection in horses.
  • The prevalence of multidrug resistance in one farm is particularly concerning, necessitating further research and new treatment strategies to counter this escalating issue.

Cite This Article

APA
Canever RJ, Braga PR, Boeckh A, Grycajuck M, Bier D, Molento MB. (2012). Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil. Vet Parasitol, 194(1), 35-39. https://doi.org/10.1016/j.vetpar.2012.12.020

Publication

Veterinary parasitology
ISSN: 1873-2550
NlmUniqueID: 7602745
Country: Netherlands
Language: English
Volume: 194
Issue: 1
Pages: 35-39
PII: S0304-4017(12)00668-1

Researcher Affiliations

Canever, Ricardo J
  • Laboratory of Parasitic Diseases, Department of Veterinary Medicine, Federal University of Paraná, Curitiba, PR, Brazil.
Braga, Pollyana R C
    Boeckh, Albert
      Grycajuck, Marcelly
        Bier, Daniele
          Molento, Marcelo B

            MeSH Terms

            • Animals
            • Antinematodal Agents / pharmacology
            • Antinematodal Agents / therapeutic use
            • Brazil
            • Drug Resistance
            • Drug Resistance, Multiple
            • Feces / parasitology
            • Female
            • Fenbendazole / pharmacology
            • Fenbendazole / therapeutic use
            • Horses
            • Macrolides / pharmacology
            • Macrolides / therapeutic use
            • Male
            • Parasite Egg Count / veterinary
            • Prevalence
            • Pyrantel / pharmacology
            • Pyrantel / therapeutic use
            • Strongyle Infections, Equine / drug therapy
            • Strongyle Infections, Equine / parasitology
            • Strongyloidea / drug effects
            • Strongyloidea / physiology

            Citations

            This article has been cited 18 times.
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