Lateral ridge augmentation using an equine flex bone block infused with recombinant human platelet-derived growth factor BB: a clinical and histologic study.
Abstract: This paper reports on a patient who underwent horizontal ridge augmentation using recombinant human platelet-derived growth factor BB (rhPDGF-BB) in combination with a collagenate equine block. Ninety days after the first surgery, 8 mm of new bone was noted on a computed tomography scan, and three 5-mm implants were placed. Histology, performed using confocal laser scanning microscopy, showed a large amount of newly formed bone well characterized with osteon and resorption lacunae, which demonstrated the intense bone remodeling. This study supports the use of rhPDGF-BB in combination with allograft blocks.
Publication Date: 2011-08-13 PubMed ID: 21837304
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Summary
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The research article discusses a successful medical procedure where a patient was treated with a specific growth factor, used in combination with a collagen block derived from horse bone, to stimulate new bone growth for dental implants.
Overview and Objective of the Study
- This clinical study aimed to research the effectiveness of recombinant human platelet-derived growth factor BB (rhPDGF-BB) in bone augmentation procedures. The rhPDGF-BB was used in combination with an equine flex bone block for lateral ridge augmentation in a patient.
Procedure and Result
- The treatment included the surgical application of the rhPDGF-BB infused equine flex bone block to the patient.
- Three months post-treatment during a follow-up examination, a computed tomography scan showed that there was an addition of 8mm of new bone in the ridge.
- Due to this successful bone growth, three dental implants of 5mm each were then placed into the new bone.
Method of Examination and Findings
- The newly formed bone was then examined using confocal laser scanning microscopy. This method allows for detailed imaging of the microstructure of the bone, providing physical evidence of the bone augmentation.
- The examination revealed a significant amount of new bone formation which was well-structured, suggesting healthy growth. The presence of osteon and resorption lacunae, features that indicate active bone remodeling, further confirmed this.
Study Conclusion
- The research conduces that the application of rhPDGF-BB combined with equine flex bone block has been effective in stimulating new bone growth necessary for dental implants.
- Based on the observed results, the study supports the coupling of these techniques for bone augmentation procedures.
Cite This Article
APA
De Angelis N, Scivetti M.
(2011).
Lateral ridge augmentation using an equine flex bone block infused with recombinant human platelet-derived growth factor BB: a clinical and histologic study.
Int J Periodontics Restorative Dent, 31(4), 383-388.
Publication
Researcher Affiliations
- University of Genova, Genova, Italy. nicola.deangelis@perio.org
MeSH Terms
- Alveolar Ridge Augmentation / methods
- Angiogenesis Inducing Agents / therapeutic use
- Animals
- Becaplermin
- Bone Remodeling / physiology
- Bone Resorption / pathology
- Bone Transplantation / methods
- Bone Transplantation / pathology
- Dental Implantation, Endosseous
- Follow-Up Studies
- Haversian System / pathology
- Horses
- Humans
- Male
- Microscopy, Confocal
- Middle Aged
- Osteogenesis / physiology
- Proto-Oncogene Proteins c-sis / therapeutic use
- Recombinant Proteins
- Tomography, X-Ray Computed
- Transplantation, Heterologous
Citations
This article has been cited 8 times.- Takayama T, Imamura K, Yamano S. Growth Factor Delivery Using a Collagen Membrane for Bone Tissue Regeneration.. Biomolecules 2023 May 10;13(5).
- Meghil MM, Mandil O, Nevins M, Saleh MHA, Wang HL. Histologic Evidence of Oral and Periodontal Regeneration Using Recombinant Human Platelet-Derived Growth Factor.. Medicina (Kaunas) 2023 Mar 29;59(4).
- Di Stefano DA, Orlando F, Ottobelli M, Fiori D, Garagiola U. A comparison between anorganic bone and collagen-preserving bone xenografts for alveolar ridge preservation: systematic review and future perspectives.. Maxillofac Plast Reconstr Surg 2022 Jul 12;44(1):24.
- Tavelli L, Ravidà A, Barootchi S, Chambrone L, Giannobile WV. Recombinant Human Platelet-Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures.. JDR Clin Trans Res 2021 Apr;6(2):161-173.
- Orlando F, Arosio F, Arosio P, Di Stefano DA. Bone Density and Implant Primary Stability. A Study on Equine Bone Blocks.. Dent J (Basel) 2019 Jul 1;7(3).
- Di Stefano DA, Zaniol T, Cinci L, Pieri L. Chemical, Clinical and Histomorphometric Comparison between Equine Bone Manufactured through Enzymatic Antigen-Elimination and Bovine Bone Made Non-Antigenic Using a High-Temperature Process in Post-Extractive Socket Grafting. A Comparative Retrospective Clinical Study.. Dent J (Basel) 2019 Jul 1;7(3).
- Lo Giudice R, Rizzo G, Centofanti A, Favaloro A, Rizzo D, Cervino G, Squeri R, Costa BG, La Fauci V, Lo Giudice G. Steam Sterilization of Equine Bone Block: Morphological and Collagen Analysis.. Biomed Res Int 2018;2018:9853765.
- Lee JS, Park WY, Cha JK, Jung UW, Kim CS, Lee YK, Choi SH. Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs.. J Periodontal Implant Sci 2012 Apr;42(2):50-8.
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