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Animals : an open access journal from MDPI2024; 14(21); 3147; doi: 10.3390/ani14213147

Lidocaine’s Ineffectiveness in Mitigating Lipopolysaccharide-Induced Pain and Peristaltic Effects in Horses.

Abstract: The present study involved seven horses in a randomized crossover clinical trial to evaluate the effect of lidocaine on horses with induced endotoxemia. Horses received intravenous lidocaine (1.5 mg/kg bolus, followed by 0.05 mg/kg bwt/min) or placebo (0.9% sodium chloride at the same manner) one hour before LPS administration (0.03 μg/kg, IV infusion over 30 min). We monitored clinic and hematologic parameters, abdominal auscultation, ultrasound, and pain over time. No relevant clinical differences existed between treatments regarding peristalsis, abdominal pain, or any other parameters before and after endotoxemia induction. These findings do not support the clinical use of lidocaine to mitigate abdominal pain and intestinal hypomotility promoted by endotoxemia in horses.
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Publication Date: 2024-11-02 PubMed ID: 39518869PubMed Central: PMC11545326DOI: 10.3390/ani14213147Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the ineffectiveness of lidocaine, a local anesthetic, in reducing pain and peristaltic effects in horses brought about by an endotoxic condition, a serious bacterial infection that can lead to systemic inflammation.

Study Design and Methodology

  • The author conducted a randomized crossover clinical trial involving seven horses. The cross-over design meant that the same horses were used in both the treatment and control groups, but at different times, thereby providing more reliable data.
  • The effect of lidocaine was evaluated by inducing endotoxemia in the horses. Endotoxemia is caused by the presence of a large quantity of endotoxins (harmful substances released when bacteria are destroyed) in the blood, which can lead to systemic inflammation and cause severe illness or death.
  • The horses were divided into groups and received either intravenous lidocaine (at a specific dosage) or a placebo (0.9% sodium chloride, also known as saline solution, given in the same fashion) one hour before LPS (lipopolysaccharide, a type of endotoxin) administration. LPS was used to mimic the bacterial infection in a controlled manner.

Monitoring and Evaluation

  • Following the administration of lidocaine or placebo and the induced endotoxemia, the researchers monitored clinical and hematologic parameters, abdominal auscultation (listening to the sounds within the abdomen), ultrasonographic images, and pain over time.
  • These parameters were monitored to understand the effect of lidocaine on common symptoms of endotoxemia in horses, such as changes in blood parameters, abdominal discomfort, and decreased peristaltic (digestive tract) movements.

Study Findings

  • The outcomes of the study revealed no significant clinical differences between treatments (i.e., between the lidocaine and placebo groups) regarding peristalsis (muscular contractions that move food through the digestive tract), abdominal pain or any other parameters before and after the induction of endotoxemia.
  • This lack of difference indicates that lidocaine, contrary to what one might suppose given its pain-relieving properties in other contexts, does not effectively mitigate abdominal pain and intestinal hypomotility (a condition wherein the movement of the food through the digestive tract slows down) promoted by endotoxemia in horses.

Implications

  • The conclusions drawn from this study suggest that lidocaine may not be an effective option for addressing abdominal pain and hypomotility in cases of endotoxemia in horses, thus informing potential future treatment decision-making in the veterinary field.
  • The absence of a strong effect of lidocaine on these symptoms could lead to further research into alternatives for the alleviation of endotoxemia-induced discomfort in horses.

Cite This Article

APA
Sousa LN, Winter IC, Varela DD, Luvison EZ, Guzmán JFC, Machado AMV, Figueiredo RDV, Pena GT, Dos Santos ACS, Faleiros RR, Carvalho AM. (2024). Lidocaine’s Ineffectiveness in Mitigating Lipopolysaccharide-Induced Pain and Peristaltic Effects in Horses. Animals (Basel), 14(21), 3147. https://doi.org/10.3390/ani14213147

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 21
PII: 3147

Researcher Affiliations

Sousa, Lara Nunes
  • EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Winter, Isabella Caixeta
  • EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Varela, Diego Duarte
  • EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Luvison, Eduarda Zancanaro
  • EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Guzmán, Juan Felipe Colmenares
  • Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Machado, Ana Moutinho Vilella
  • Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Figueiredo, Renata Diniz Vilela
  • Veterinary Medicine, Pontifical Catholic University of Minas Gerais, Belo Horizonte 30140-002, Brazil.
Pena, Gabriel Tavares
  • Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Dos Santos, Ana Clara Silva
  • Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Faleiros, Rafael Resende
  • EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
  • CNPq Research Fellow, National Council for Scientific and Technological Development (CNPq), Brasília 71605-001, Brazil.
Carvalho, Armando de Mattos
  • EQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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