Linkage disequilibrium between the ELA and the A blood group systems in Standardbred horses.
Abstract: The linkage group formed by the ELA and A blood group system in horses was studied in American Standardbred horses. The distance between the ELA locus and the A blood group locus was measured as 1.61 centimorgans, observing only the haplotypes contributed by the sires. Strong linkage disequilibrium was found in pacing Standardbred horses for ELA-W1 with Aa, ELA-W5 with Ab and ELA-W10 with Ab. Linkage disequilibrium was apparent at both the population and family level. Among trotting Standardbred horses, linkage disequilibrium was found for ELA-W1 with Aa and for ELA-W10 with Ab. It was not possible to investigate linkage relationships in Thoroughbred horses because of the high frequency of Aa and low frequency of other A system markers.
Publication Date: 1983-01-01 PubMed ID: 6577806DOI: 10.1111/j.1365-2052.1983.tb01058.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study focuses on the relationship and genetic linkage between the ELA and the A blood group systems in Standardbred horses. The research found a strong connection between specific ELA and blood types within both pacing and trotting Standardbred horses.
Background and Objectives
- The research aimed to explore the linkage group formed by the Equine Lymphocyte Antigen (ELA) and A blood group system in Standardbred horses. Standardbreds are a breed of horses typically used in harness racing.
- The main objective was to ascertain the genetic relationship between ELA locus (a fixed position on a chromosome where a particular gene is located) and A blood group locus within this horse breed.
Methodology
- The researchers analyzed the genetic distance between the ELA and A blood group locus, observing the haplotypes contributed by the sires (male progenitors) of the breed.
- The measurement unit used in these observations was centimorgans (cM), which is a standard unit of measure of genetic recombination or crossover events.
Key Findings
- The research found a distance of 1.61 centimorgans between the ELA locus and the A blood group locus.
- Within the pacing Standardbred horses, a particular breed bred for a specific type of gait, there was strong linkage disequilibrium (a non-random association of alleles at two or more loci) for ELA-W1 with blood type Aa, ELA-W5 with Ab and ELA-W10 with Ab. This was observed at both the population and family level.
- For trotting Standardbred horses, another breed bred for a different gait, a significant linkage disequilibrium was noted between ELA-W1 with Aa and ELA-W10 with Ab.
- In both breeds of horses, these findings indicate a significant genetic association between certain ELA and blood types.
Limitations
- The linkage relationships could not be investigated in Thoroughbred horses due to a high frequency of Aa and low frequency of other A system markers. This refers to the high prevalence of the same blood type (Aa) in Thoroughbred horses, making it challenging to analyze any genetic relationships.
Cite This Article
APA
Bailey E.
(1983).
Linkage disequilibrium between the ELA and the A blood group systems in Standardbred horses.
Anim Blood Groups Biochem Genet, 14(1), 37-43.
https://doi.org/10.1111/j.1365-2052.1983.tb01058.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Blood Group Antigens / genetics
- Genes
- Genetic Linkage
- Genetic Markers
- Histocompatibility Antigens / genetics
- Horses / genetics
Citations
This article has been cited 2 times.- Bailey E. Segregation distortion within the equine MHC; analogy to a mouse T/t-complex trait. Immunogenetics 1986;24(4):225-9.
- Lew AM, Bailey E, Valas RB, Coligan J. The gene encoding the equine soluble class I molecule is linked to the horse MHC. Immunogenetics 1986;24(2):128-30.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
