Longitudinal study of the renin angiotensin aldosterone system in purebred Spanish broodmares during pregnancy.
Abstract: During pregnancy, the coordinated interaction of the components of the renin-angiotensin-aldosterone system (RAAS) plays a vital role in accommodating the cardiovascular, haemodynamic and haematological needs imposed by foetal development and the placenta. This significantly influences the birth weight of the neonate and foetal viability. Although the evolution of each of the components of this system has been widely described in various species, it has not yet been clarified in the mare. Thus, the objectives of the present research were: 1) to establish reference values for renin (REN), angiotensin II (ANG-II) and aldosterone (ALD) concentrations in Spanish broodmares, and 2) to analyse the evolution of the aforementioned components during pregnancy. Thirty-one Purebred Spanish broodmares aged between 5 and 15 years old were studied for 11 months of pregnancy and compared to a control group composed of 11 non-pregnant Spanish mares. Morning venous blood samples were drawn on a monthly basis during pregnancy and pre-treated to prevent degradation until subsequent analysis. Serum REN, ANG-II and ALD concentrations were analysed by competitive immunoassay. This study found that pregnancy in Purebred Spanish broodmares is characterised by a gradual increase in REN concentrations, variable fluctuations in ALD concentrations, and no significant modifications in ANG-II concentrations. These results could provide potentially valuable information in understanding the physiological basis of the RAAS in mares, since we have been able to establish specific reference ranges for these components, as well as obtaining information on their evolution during pregnancy. As is often the case in other animal species, the increase in RAAS activity is a natural physiological process that occurs during pregnancy in Spanish broodmares. This may also be related to certain metabolic and hormone responses that contribute to the control of homeostasis in pregnant mares.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication Date: 2011-01-08 PubMed ID: 21220157DOI: 10.1016/j.theriogenology.2010.11.029Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article conducts a study on the renin-angiotensin-aldosterone system (RAAS) in pregnant Spanish mares in order to understand its functioning and its influence on foetal viability and birth weight. The results establish reference values for this system’s components and their evolution throughout pregnancy.
Objectives and Methodology
- The main objectives of the study were to set reference values for renin, angiotensin II, and aldosterone concentrations in pregnant Spanish mares and to analyze these components’ development throughout pregnancy.
- Over 11 months, the study followed 31 pregnant Purebred Spanish mares aged between 5 to 15 years. Their results were compared to a control group of 11 non-pregnant mares of the same breed.
- The research team drew venous blood samples monthly from each mare during pregnancy. These samples were treated to prevent degradation until analysis.
- The serum concentrations of renin, angiotensin II, and aldosterone were eventually analyzed using a competitive immunoassay.
Findings
- The research found that pregnancy in Purebred Spanish mares usually involved a gradual increase in renin concentrations. In contrast, aldosterone concentrations presented variable fluctuations, and the angiotensin II concentrations did not see any significant changes.
- These findings helped establish specific reference ranges for the components of the renin-angiotensin-aldosterone system.
- The research also provides insights into each component’s development during pregnancy in mares.
Implications
- This research has potentially broad implications, as it adds to our understanding of the physiological functioning of the renin-angiotensin-aldosterone system in mares.
- The increase in activity of the RAAS across the pregnancy cycle is a natural physiological process, and these findings might be correlated with specific metabolic and hormone responses that help maintain homeostasis in pregnant mares.
- Understanding the dynamics of this system may, in time, contribute to securing foetal viability and optimal birth weight.
Cite This Article
APA
Satué K, Domingo R.
(2011).
Longitudinal study of the renin angiotensin aldosterone system in purebred Spanish broodmares during pregnancy.
Theriogenology, 75(7), 1185-1194.
https://doi.org/10.1016/j.theriogenology.2010.11.029 Publication
Researcher Affiliations
- Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Cardenal Herrera University, Valencia, Spain. ksatue@uch.ceu.es
MeSH Terms
- Aldosterone / blood
- Angiotensin II / blood
- Animals
- Breeding
- Female
- Gestational Age
- Horses / blood
- Horses / metabolism
- Horses / physiology
- Longitudinal Studies
- Osmolar Concentration
- Pregnancy / blood
- Pregnancy, Animal / blood
- Renin / blood
- Renin-Angiotensin System / physiology
Citations
This article has been cited 5 times.- Satué K, Fazio E, La Fauci D, Medica P. Hematological indexes and iron status in pregnant mares.. Arch Anim Breed 2023;66(3):197-205.
- Satué K, Fazio E, Muñoz A, Medica P. Endocrine and Electrolyte Balances during Periovulatory Period in Cycling Mares.. Animals (Basel) 2021 Feb 17;11(2).
- Vernemmen I, Vera L, Van Steenkiste G, van Loon G, Decloedt A. Reference values for 2-dimensional and M-mode echocardiography in Friesian and Warmblood horses.. J Vet Intern Med 2020 Nov;34(6):2701-2709.
- Faramarzi B, Rich LJ, Wu J. Hematological and serum biochemical profile values in pregnant and non-pregnant mares.. Can J Vet Res 2018 Oct;82(4):287-293.
- Pohlin F, Brabender K, Fluch G, Stalder G, Petit T, Walzer C. Seasonal Variations in Heart Rate Variability as an Indicator of Stress in Free-Ranging Pregnant Przewalski's Horses (E. ferus przewalskii) within the Hortobágy National Park in Hungary.. Front Physiol 2017;8:664.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
