FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Anim Reprod Sci / Luteal blood flow and progesterone production in mares.
Animal reproduction science2006; 99(1-2); 213-220; doi: 10.1016/j.anireprosci.2006.05.018

Luteal blood flow and progesterone production in mares.

Abstract: The temporal relationships between blood flow in the corpus luteum (CL) and circulating progesterone concentrations were studied in 20 mares. Retrospective inspection of plasma progesterone concentrations indicated that a precipitous decrease occurred during Days 15-17 (Day 0 = ovulation) and was defined as the luteolytic period. Mean percentage of CL with color-Doppler signals for blood flow was maximum on Day 10 (77.3%), and Days 10-14 (49.8%) were defined as the preluteolytic period. The cross-sectional area of the CL decreased progressively from Day 4 (9.0 cm2) to Day 19 (1.5 cm2). Progesterone reached maximum concentration on Day 8 (12.8 ng/ml) and thereafter CL area and plasma progesterone decreased in parallel until the onset of luteolysis. During the luteolytic period, the decrease in plasma progesterone was about sixfold greater than during the preluteolytic period, whereas the decrease in CL area and in percentage of CL with blood-flow area were about twofold greater. There was no indication that an acute increase or decrease in luteal blood flow occurred prior to the precipitous decrease in plasma progesterone.
(c)2006 Elsevier B.V. All rights reserved.
Get Full Text
Publication Date: 2006-05-22 PubMed ID: 16815650DOI: 10.1016/j.anireprosci.2006.05.018Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the relationship between blood flow in the corpus luteum (CL) and circulating progesterone levels in mares. It reveals that a significant decrease in progesterone and blood flow to the CL transpires around days 15-17 (taking ovulation as day 0) and decreases further towards days 19, hinting this might be tied to the reproductive cycle in mares.

Study Overview

  • The researchers studied the temporal relationships between the corpus luteum (CL) blood flow and circulating concentrations of progesterone in 20 mares.
  • This study aimed to determine the correlation between progesterone levels and CL blood flow, and how these are connected to the reproductive cycle of mares.

Key Findings

  • The researchers found a significant decrease in plasma progesterone concentrations on Days 15-17, a period referred to as the luteolytic period.
  • There was an observable maximum mean percentage of CL with color-Doppler signals showing blood flow on Day 10, and the period from Days 10-14 was defined as the preluteolytic period.
  • The cross-sectional area of the CL diminished gradually from Day 4 to Day 19.
  • It was noted that progesterone reached maximum concentration on Day 8, thereafter, the CL area and plasma progesterone dropped in parallel until the beginning of luteolysis.
  • The decrease in plasma progesterone during the luteolytic period was approximately six times greater than during the preluteolytic period. Meanwhile, the decrease in CL area and blood-flow area within the CL were about twofold greater.
  • There was no evidence suggesting an abrupt increase or decrease in luteal blood flow prior to the significant decrease in plasma progesterone.

Significance

  • Understanding the relationship between luteal blood flow and progesterone production in mares provides valuable insights into the physiological and hormonal changes during their reproductive cycle.
  • The findings could contribute to the improved reproductive management of mares and other equine animals.

Cite This Article

APA
Ginther OJ, Gastal EL, Gastal MO, Utt MD, Beg MA. (2006). Luteal blood flow and progesterone production in mares. Anim Reprod Sci, 99(1-2), 213-220. https://doi.org/10.1016/j.anireprosci.2006.05.018

Publication

Animal reproduction science
ISSN: 0378-4320
NlmUniqueID: 7807205
Country: Netherlands
Language: English
Volume: 99
Issue: 1-2
Pages: 213-220

Researcher Affiliations

Ginther, O J
  • Eutheria Foundation, Cross Plains, WI 53528, USA. ginther@svm.vetmed.wisc.edu
Gastal, E L
    Gastal, M O
      Utt, M D
        Beg, M A

          MeSH Terms

          • Animals
          • Blood Flow Velocity / physiology
          • Blood Vessels / diagnostic imaging
          • Corpus Luteum / blood supply
          • Corpus Luteum / diagnostic imaging
          • Estrous Cycle / physiology
          • Female
          • Horses / physiology
          • Linear Models
          • Progesterone / blood
          • Progesterone / metabolism
          • Retrospective Studies
          • Time Factors
          • Ultrasonography, Doppler / veterinary

          Citations

          This article has been cited 17 times.
          1. Freccero F, Mislei B, Bucci D, Dondi F, Mari G. Effects of Intra-Uterine Fluid Accumulation after Artificial Insemination on Luteal Function in Mares. Animals (Basel) 2022 Dec 23;13(1).
            doi: 10.3390/ani13010067pubmed: 36611677google scholar: lookup
          2. Ortega-Ferrusola C, Gómez-Arrones V, Martín-Cano FE, Gil MC, Peña FJ, Gaitskell-Phillips G, Da Silva-Álvarez E. Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. Reprod Domest Anim 2022 Oct;57 Suppl 5(Suppl 5):34-44.
            doi: 10.1111/rda.14192pubmed: 35748405google scholar: lookup
          3. Segabinazzi LGTM, Roberts BN, Peterson EW, Ambrosia R, Bergfelt D, Samper J, French H, Gilbert RO. Early Pregnancy in Jennies in the Caribbean: Corpus Luteum Development and Progesterone Production, Uterine and Embryo Dynamics, Conceptus Growth and Maturation. Animals (Basel) 2022 Jan 6;12(2).
            doi: 10.3390/ani12020127pubmed: 35049751google scholar: lookup
          4. Requena F, Campos MJAPM, Martínez Marín AL, Camacho R, Giráldez-Pérez RM, Agüera EI. Assessment of Age Effects on Ovarian Hemodynamics Using Doppler Ultrasound and Progesterone Concentrations in Cycling Spanish Purebred Mares. Animals (Basel) 2021 Aug 8;11(8).
            doi: 10.3390/ani11082339pubmed: 34438797google scholar: lookup
          5. Zampini EG, Gallelli MF, Chaves MG, Neild DM, Gambarotta M, Miragaya MH, Trasorras VL. Uterine and Corpus Luteum Blood Flow Evaluation Prior to Uterine Flushing in Llama Embryo Donors. Front Vet Sci 2020;7:597960.
            doi: 10.3389/fvets.2020.597960pubmed: 33282934google scholar: lookup
          6. Alonso MA, Silva LA, Affonso FJ, Lemes KM, Celeghini ECC, Lançoni R, Carvalho HF, de Arruda RP. Effect of hCG application at different moments of the estrous cycle on corpus luteum and uterine vascularization and serum progesterone concentration in mares. Anim Reprod 2019 Oct 24;16(2):317-327.
            doi: 10.21451/1984-3143-AR2018-0103pubmed: 33224293google scholar: lookup
          7. Salzano A, Russo M, Anglani G, Licitra F, Zullo G, Cotticelli A, Fatone G, Campanile G. Early Prediction of Corpus Luteum Functionality Using an Imaging Software. Front Vet Sci 2020;7:299.
            doi: 10.3389/fvets.2020.00299pubmed: 32626727google scholar: lookup
          8. Walewska E, Wołodko K, Skarzynski D, Ferreira-Dias G, Galvão A. The Interaction Between Nodal, Hypoxia-Inducible Factor 1 Alpha, and Thrombospondin 1 Promotes Luteolysis in Equine Corpus Luteum. Front Endocrinol (Lausanne) 2019;10:667.
            doi: 10.3389/fendo.2019.00667pubmed: 31632347google scholar: lookup
          9. Beltrame RT, Morais Junior NN, Careta JVP, Ribeiro AP, Lima TAD, da Costa RLD, Quirino CR. Uterine hemodynamics during a short-term progesterone synchronization protocol in ewes. Trop Anim Health Prod 2020 Mar;52(2):503-509.
            doi: 10.1007/s11250-019-02035-5pubmed: 31392554google scholar: lookup
          10. Hassan M, Arshad U, Bilal M, Sattar A, Avais M, Bollwein H, Ahmad N. Luteal blood flow measured by Doppler ultrasonography during the first three weeks after artificial insemination in pregnant and non-pregnant Bos indicus dairy cows. J Reprod Dev 2019 Feb 8;65(1):29-36.
            doi: 10.1262/jrd.2018-084pubmed: 30393273google scholar: lookup
          11. Siemieniuch MJ, Szóstek AZ, Gajos K, Kozdrowski R, Nowak M, Okuda K. Type of Inflammation Differentially Affects Expression of Interleukin 1β and 6, Tumor Necrosis Factor-α and Toll-Like Receptors in Subclinical Endometritis in Mares. PLoS One 2016;11(5):e0154934.
            doi: 10.1371/journal.pone.0154934pubmed: 27152525google scholar: lookup
          12. Derar RI, Hussein HA. Ovarian Follicular Dynamics during the Estrous Cycle in Jennies in Upper Egypt. Vet Med Int 2011;2011:860518.
            doi: 10.4061/2011/860518pubmed: 21647342google scholar: lookup
          13. Araujo RR, Ginther OJ, Ferreira JC, Palhão MM, Beg MA, Wiltbank MC. Role of follicular estradiol-17beta in timing of luteolysis in heifers. Biol Reprod 2009 Aug;81(2):426-37.
            doi: 10.1095/biolreprod.108.073825pubmed: 19264702google scholar: lookup
          14. Jitjumnong J, Yama P, Sangkate M, Suriard A, Butmata W, Daoloy N, Taweechaipaisankul A, Buddhasiri S, Lin CJ, Zhang Y, Moonmanee T. Rewiring the luteal microenvironment: hemodynamic and molecular insights into eCG-supported CL development in indigenous White Lamphun cattle. Reprod Fertil 2025 Oct 1;6(4).
            doi: 10.1530/RAF-25-0086pubmed: 41251457google scholar: lookup
          15. Alkhadrawy JMH, Aboelmaaty AM, Abou-Ahmed MM, Ghallab AM. Effect of hCG and prostaglandin on ovarian, luteal development, and hormonal changes in embryo donor mares during the hot summer months in subtropics. Open Vet J 2024 Aug;14(8):2057-2072.
            doi: 10.5455/OVJ.2024.v14.i8.35pubmed: 39308718google scholar: lookup
          16. Alkhadrawy JMH, Aboelmaaty AM, Abou-Ahmed MM, Ghallab AM. Effect of breeding season and age on follicular dynamics and hemodynamics in embryo donor mares subjected to luteolysis after embryo flushing. Open Vet J 2024 Mar;14(3):852-865.
            doi: 10.5455/OVJ.2024.v14.i3.13pubmed: 38682132google scholar: lookup
          17. Monaco CF, Davis JS. Mechanisms of angioregression of the corpus luteum. Front Physiol 2023;14:1254943.
            doi: 10.3389/fphys.2023.1254943pubmed: 37841308google scholar: lookup
          Subscribe to our newsletter
          Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.