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Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association2016; 57(5); 502-514; doi: 10.1111/vru.12369

Magnetic Resonance Imaging Scoring of an Experimental Model of Post-Traumatic Osteoarthritis in the Equine Carpus.

Abstract: Magnetic resonance imaging (MRI) is the most sensitive imaging modality to detect the early changes of osteoarthritis. Currently, there is no quantifiable method to tract these pathological changes over time in the horse. The objective of this experimental study was to characterize the progression of MRI changes in an equine model of post-traumatic osteoarthritis using a semiquantitative scoring system for whole-organ evaluation of the middle carpal joint. On day 0, an osteochondral fragment was created in one middle carpal joint (OCI) and the contralateral joint (CON) was sham-operated in 10 horses. On day 14, study horses resumed exercise on a high-speed treadmill until the completion of the study (day 98). High-field MRI examinations were performed on days 0 (preosteochondral fragmentation), 14, and 98 and scored by three blinded observers using consensus agreement. Images were scored based on 15 independent articular features, and scores were compared between and within-groups. On days 14 and 98, OCI joints had significantly (P ≤ 0.05) higher whole-organ median scores (29.0 and 31.5, respectively), compared to CON joints (21.5 and 20.0, respectively). On day 14, OCI joints showed significant increases in high-signal bone lesion scores, and osteochondral fragment number and size. On day 98, high-signal bone lesion, low-signal bone lesion, osteophyte formation, cartilage signal abnormality, subchondral bone irregularity, joint effusion, and synovial thickening scores were significantly increased in OCI joints. Study results suggest that the MRI whole-organ scoring system reported here may be used to identify onset and progression of pathological changes following osteochondral injury.
© 2016 American College of Veterinary Radiology.
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Publication Date: 2016-05-19 PubMed ID: 27198611PubMed Central: PMC5016209DOI: 10.1111/vru.12369Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study details the use of magnetic resonance imaging (MRI) to track the progression of osteoarthritis in horses, by using a new scoring system for whole-organ evaluation. An induced injury model was adopted to create osteoarthritis in the horses’ joints, and then a semi-quantitative MRI score calculated to monitor changes over time.

Research Approach

  • The researchers initiated the study by creating an equine model of post-traumatic osteoarthritis. This was done by artificially inducing an osteochondral fragment into one middle carpal joint of the horse, while the other joint was sham-operated for control comparison.
  • High-speed treadmill exercise was resumed for the horses 14 days after the operation and continued until the study completed after 98 days.
  • High-field MRI examinations were performed on the 0th day (prior to osteochondral fragmentation), 14th day, and 98th day. All MRI images were scored blind by three observers using a system based on consensus agreement.

Scoring Parameters

  • A total of 15 independent articular features formed the basis of the MRI scoring system.
  • The scoring parameters included bone lesion signals (both high and low), the size, and number of osteochondral fragments, osteophyte formation (bony outgrowth), cartilage signal abnormality, irregularity of subchondral bone, and both joint effusion and synovial thickening.

Results

  • In the artificial osteoarthritis joints (OCI), the whole organ’s median scores demonstrated significantly higher values on the 14th and 98th day when compared to the control joints. OCI joints showed significant increases in high-signal bone lesion scores, and the number and size of osteochondral fragments on day 14.
  • By day 98, the scores of high-signal bone lesion, low-signal bone lesion, osteophyte formation, cartilage signal abnormality, subchondral bone irregularity, joint effusion, and synovial thickening were significantly higher in OCI joints.

Conclusion

  • Based on these results, the study suggests that the MRI whole-organ scoring mechanism devised can effectively identify the onset and progression of pathological changes happening after osteochondral injury.

Cite This Article

APA
Smith AD, Morton AJ, Winter MD, Colahan PT, Ghivizzani S, Brown MP, Hernandez JA, Nickerson DM. (2016). Magnetic Resonance Imaging Scoring of an Experimental Model of Post-Traumatic Osteoarthritis in the Equine Carpus. Vet Radiol Ultrasound, 57(5), 502-514. https://doi.org/10.1111/vru.12369

Publication

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
ISSN: 1740-8261
NlmUniqueID: 9209635
Country: England
Language: English
Volume: 57
Issue: 5
Pages: 502-514

Researcher Affiliations

Smith, Andrew D
  • Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.
Morton, Alison J
  • Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608. mortona@ufl.edu.
Winter, Matthew D
  • Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.
Colahan, Patrick T
  • Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.
Ghivizzani, Steve
  • Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Univeristy of Florida, Gainesville, FL, 32608.
Brown, Murray P
  • Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.
Hernandez, Jorge A
  • Department of Large Animal Clinical Sciences, University of Florida College of Veterinary Medicine, University of Florida, Gainesville, FL, 32608.
Nickerson, David M
  • Department of Statistics, University of Central Florida, Orlando, FL, 32816.

MeSH Terms

  • Animals
  • Carpal Joints / diagnostic imaging
  • Carpus, Animal / diagnostic imaging
  • Female
  • Horse Diseases / diagnostic imaging
  • Horse Diseases / etiology
  • Horses
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging / veterinary
  • Male
  • Osteoarthritis / diagnostic imaging
  • Osteoarthritis / etiology
  • Osteoarthritis / veterinary

Grant Funding

  • R01 AR048566 / NIAMS NIH HHS

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