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Biosecurity and bioterrorism : biodefense strategy, practice, and science2013; 11 Suppl 1; S191-S199; doi: 10.1089/bsp.2012.0089

Management of animal botulism outbreaks: from clinical suspicion to practical countermeasures to prevent or minimize outbreaks.

Abstract: Botulism is a severe neuroparalytic disease that affects humans, all warm-blooded animals, and some fishes. The disease is caused by exposure to toxins produced by Clostridium botulinum and other botulinum toxin-producing clostridia. Botulism in animals represents a severe environmental and economic concern because of its high mortality rate. Moreover, meat or other products from affected animals entering the food chain may result in a public health problem. To this end, early diagnosis is crucial to define and apply appropriate veterinary public health measures. Clinical diagnosis is based on clinical findings eliminating other causes of neuromuscular disorders and on the absence of internal lesions observed during postmortem examination. Since clinical signs alone are often insufficient to make a definitive diagnosis, laboratory confirmation is required. Botulinum antitoxin administration and supportive therapies are used to treat sick animals. Once the diagnosis has been made, euthanasia is frequently advisable. Vaccine administration is subject to health authorities' permission, and it is restricted to a small number of animal species. Several measures can be adopted to prevent or minimize outbreaks. In this article we outline all phases of management of animal botulism outbreaks occurring in wet wild birds, poultry, cattle, horses, and fur farm animals.
Publication Date: 2013-11-06 PubMed ID: 23971806DOI: 10.1089/bsp.2012.0089Google Scholar: Lookup
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  • Journal Article

Summary

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The research paper presents a comprehensive guide on managing outbreaks of botulism in animals, from initial clinical suspicion to introducing preventive measures, as botulism represents a severe economic and environmental concern due to high animal mortality rates and potential public health problems.

Neuroparalytic Disease and its Impact

  • Botulism is a severe neuroparalytic disease impacting humans, all warm-blooded animals, and some fish. It is produced by exposure to toxins from Clostridium botulinum and other similar toxin-producing bacteria.
  • The disease poses a significant environmental and economic risk due to its high mortality rate in animals.
  • There’s also a public health risk when meat or other products from infected animals enter the human food chain.

Importance of Early Diagnosis and Treatment

  • Early diagnosis is crucial to defining and applying appropriate protective health measures for animals.
  • The identification of botulism is primarily based on clinical findings, coupled with elimination of other possible causes of neuromuscular disorders. Postmortem examination revealing the absence of internal lesions is also a contributing factor.
  • However, clinical signs alone are often insufficient for confirmatory diagnosis necessitating laboratory testing.
  • Treatment involves the administration of botulinum antitoxin and supportive therapies. However, euthanasia is often advisable once the diagnosis confirms botulism.

Vaccination and Other Preventive Measures

  • Vaccination is subject to the permission of health authorities and is restricted to a select number of animal species.
  • The article lists several measures that can be adapted to prevent or minimize outbreaks of botulism in animals.
  • The document covers comprehensive management of animal botulism outbreaks in several animal categories such as wet wild birds, poultry, cattle, horses, and fur farm animals.

Cite This Article

APA
Anniballi F, Fiore A, Löfström C, Skarin H, Auricchio B, Woudstra C, Bano L, Segerman B, Koene M, Båverud V, Hansen T, Fach P, Tevell Aberg A, Hedeland M, Olsson Engvall E, De Medici D. (2013). Management of animal botulism outbreaks: from clinical suspicion to practical countermeasures to prevent or minimize outbreaks. Biosecur Bioterror, 11 Suppl 1, S191-S199. https://doi.org/10.1089/bsp.2012.0089

Publication

ISSN: 1557-850X
NlmUniqueID: 101156085
Country: United States
Language: English
Volume: 11 Suppl 1
Pages: S191-S199

Researcher Affiliations

Anniballi, Fabrizio
  • Fabrizio Anniballi, CLT, is a Laboratory Technician; Alfonsina Fiore, PhD, is a Researcher; Bruna Auricchio, CLT, is a Laboratory Technician; and Dario De Medici, PhD, is Senior Researcher, all at Istituto Superiore di Sanità (ISS), Department of Veterinary Public Health and Food Safety, Rome, Italy. Charlotta Löfström, PhD, is an Assistant Professor, and Trine Hansen, MSc, is a PhD student, both at the National Food Institute, Technical University of Denmark (DTU), Søborg, Denmark. Hanna Skarin, MSc, is a Research Assistant; Bo Segerman, PhD, is is a Researcher; Viveca Båverud, PhD, is Associate Professor; Eva Olsson Engvall, PhD, is Associate Professor; all in the Department of Bacteriology, National Veterinary Institute (SVA), Uppsala, Sweden, and Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden. Cédric Woudstra, MSc, is an Engineer, and Patrick Fach, PhD, is Head of the High Throughput qPCR Platform IdentyPath, both at the French Agency for Food, Environmental and Occupational Health Safety (ANSES), Food Safety Laboratory, Maisons-Alfort, France. Luca Bano, PhD, is Veterinary Officer, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Veterinary Diagnostic Laboratory of Treviso, Treviso, Italy. Miriam Koene, DVM, is a Scientist, Central Veterinary Institute of Wageningen University and Research Centre (CVI) , Lelystad, the Netherlands. Annica Tevell Åberg, PhD, is a Senior Researcher, and Mikael Hedeland, PhD, is Associate Professor and Deputy Head of the Department, Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), Uppsala, Sweden .
Fiore, Alfonsina
    Löfström, Charlotta
      Skarin, Hanna
        Auricchio, Bruna
          Woudstra, Cédric
            Bano, Luca
              Segerman, Bo
                Koene, Miriam
                  Båverud, Viveca
                    Hansen, Trine
                      Fach, Patrick
                        Tevell Aberg, Annica
                          Hedeland, Mikael
                            Olsson Engvall, Eva
                              De Medici, Dario

                                MeSH Terms

                                • Animal Diseases / diagnosis
                                • Animal Diseases / prevention & control
                                • Animal Diseases / therapy
                                • Animals
                                • Botulinum Toxins
                                • Botulism / diagnosis
                                • Botulism / prevention & control
                                • Botulism / therapy
                                • Botulism / veterinary
                                • Cattle
                                • Clostridium botulinum
                                • Horses
                                • Poultry
                                • Vaccination

                                Citations

                                This article has been cited 22 times.