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Reproduction (Cambridge, England)2021; 161(6); R139-R155; doi: 10.1530/REP-20-0437

Maternal recognition of pregnancy in the mare: does it exist and why do we care?

Abstract: Maternal recognition of pregnancy (MRP) is a process by which an early conceptus signals its presence to the maternal system and prevents the lysis of the corpus luteum, thus ensuring a maternal milieu supportive of pregnancy continuation. It is a fundamental aspect of reproductive biology, yet in the horse, the mechanism underlying MRP remains unknown. This review seeks to address some of the controversies surrounding the evidence and theories of MRP in the equine species, such as the idea that the horse does not conform to the MRP paradigm established in other species or that equine MRP involves a mechanical, rather than chemical, signal. The review examines the challenges of studying this particularly clandestine phenomenon along with the new tools in scientific research that will drive this quest forward in coming years, and discuss the value of knowledge gleaned along this path in the context of clinical applications for improving breeding outcomes in the horse industry.
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Publication Date: 2021-05-05 PubMed ID: 33957605PubMed Central: PMC8183633DOI: 10.1530/REP-20-0437Google Scholar: Lookup
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  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focusses on the concept of Maternal Recognition of Pregnancy (MRP) in horses, exploring theories and controversies, challenges in studying this phenomenon, and its potential application in the horse breeding industry.

Understanding Maternal Recognition of Pregnancy (MRP) in horses

In the body of the report, the authors delve into the process of MRP, which acts as a communication tool between the early embryo and the mother’s system. This interaction signals that pregnancy has begun and prevents the breakdown of the corpus luteum, a structure necessary during early pregnancy. It is crucial because it creates a favorable environment in the mother’s body to support the continuation of the pregnancy.

  • The authors highlight that while this is a fundamental aspect of reproductive biology, its functioning is not fully understood in horses.
  • The discussion sheds light on various controversies about MRP in horses. One of the controversies argues that horses do not follow the same MRP pattern observed in other species. Another theory suggests that the MRP in horses involves a physical signal rather than a chemical one.

Research Challenges and Future Directions

This part of the research paper examines the challenges of studying this relatively secretive phenomenon.

  • The clandestine nature of this process leads to difficulties in its research. However, the authors remain positive about the future of the field as new tools and methodologies in scientific research will aid in advancing our understanding of MRP in the coming years.
  • The research also implies that unlocking the mystery behind MRP could have significant therapeutic implications, particularly in improving the outcomes of horse breeding. This could potentially lead to a greater understanding of fertility and reproductive efficiency not only in horses but also other species.

Cite This Article

APA
Swegen A. (2021). Maternal recognition of pregnancy in the mare: does it exist and why do we care? Reproduction, 161(6), R139-R155. https://doi.org/10.1530/REP-20-0437

Publication

Reproduction (Cambridge, England)
ISSN: 1741-7899
NlmUniqueID: 100966036
Country: England
Language: English
Volume: 161
Issue: 6
Pages: R139-R155
PII: REP-20-0437

Researcher Affiliations

Swegen, Aleona
  • Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
  • Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia.

MeSH Terms

  • Animals
  • Corpus Luteum Maintenance
  • Embryonic Development
  • Female
  • Horses
  • Pregnancy
  • Pregnancy, Animal

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