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Home / Equine Research Bank / Equine Vet J / Mesenchymal stem cell therapy in equine musculoskeletal dise...
Equine veterinary journal2007; 39(2); 172-180; doi: 10.2746/042516407x180868

Mesenchymal stem cell therapy in equine musculoskeletal disease: scientific fact or clinical fiction?

Abstract: The goal in the therapeutic use of mesenchymal stem cells (MSCs) in musculoskeletal disease is to harness the regenerative nature of these cells focussing on their potential to grow new tissues and organs to replace damaged or diseased tissue. Laboratory isolation of MSCs is now well established and has recently been demonstrated for equine MSCs. Stem cell science has attracted considerable interest in both the scientific and clinical communities because of its potential to regenerate tissues. Research into the use of MSCs in tissue regeneration in general reflects human medical needs, however, the nature, prevalence and prognosis of superficial digital flexor tendonitis has put equine veterinary science at the forefront of tendon regeneration research. Much has been investigated and learnt but it must be appreciated that in spite of this, the field is still relatively young and both communities must prepare themselves for considerable time and effort to develop the technology into a highly efficient treatments. The promise of functional tissue engineering to replace old parts with new fully justifies the interest. At present, however, it is important to balance the understanding of our current limitations with a desire to progress the technology.
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Publication Date: 2007-03-24 PubMed ID: 17378447DOI: 10.2746/042516407x180868Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper discusses the potential of mesenchymal stem cells (MSCs) for treating musculoskeletal diseases in horses, particularly in tendon regeneration. Although the field shows promise, the authors stress that it is still in its early stages and has limitations to work through.

Regenerative Capabilities of MSCs

  • The authors first explain the fundamental idea behind mesenchymal stem cell therapy. It utilizes the regenerative properties of these cells to grow new tissues and organs as substitutes for diseased or damaged ones. Such a process could open up new therapies for a broad range of diseases, including musculoskeletal ones.

Application in Equine Medicine

  • Mesenchymal stem cell research sees a lot of interest from both scientific and clinical communities. However, the focus here is primarily on human medical needs.
  • The authors bring attention to equine veterinary science. The field’s particular problem with superficial digital flexor tendonitis (a common and serious condition in horses) has turned it into a hotbed of tendon regeneration research using stem cells.

Current Status of the Field

  • The authors acknowledge that despite much research, the field of mesenchymal stem cell therapy is still very young. There is still a lot of time and effort needed to develop this technology into efficient treatments reliably.
  • The concept of functional tissue engineering deserves interest given its potential to replace old, diseased body parts with new, fully functioning ones.

Consideration of Limitations

  • The authors emphasize it is crucial to recognize and understand the current limitations of the technology. They urge a balanced outlook that acknowledges these limitations while continuing to push forward with the research and technology development.

Cite This Article

APA
Taylor SE, Smith RK, Clegg PD. (2007). Mesenchymal stem cell therapy in equine musculoskeletal disease: scientific fact or clinical fiction? Equine Vet J, 39(2), 172-180. https://doi.org/10.2746/042516407x180868

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 39
Issue: 2
Pages: 172-180

Researcher Affiliations

Taylor, S E
  • Department of Veterinary Clinical Science, University of Liverpool, Leahurst, Chester High Road, Neston, Cheshire CH64 7TE, UK.
Smith, R K W
    Clegg, P D

      MeSH Terms

      • Animals
      • Bone Regeneration / physiology
      • Cartilage / cytology
      • Cartilage / physiology
      • Cell Differentiation
      • Horse Diseases / therapy
      • Horses
      • Mesenchymal Stem Cell Transplantation / methods
      • Mesenchymal Stem Cell Transplantation / veterinary
      • Mesenchymal Stem Cells
      • Musculoskeletal Diseases / therapy
      • Musculoskeletal Diseases / veterinary
      • Tendons / cytology
      • Tendons / physiology
      • Tissue Engineering / veterinary

      Citations

      This article has been cited 24 times.
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