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Home / Equine Research Bank / Front Microbiol / Microbiome analysis reveals dynamic changes of gut microbiot...
Frontiers in microbiology2025; 16; 1562482; doi: 10.3389/fmicb.2025.1562482

Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses.

Abstract: In recent years, the importance of gut microbiota in digestive absorption, metabolism, and immunity has garnered increasing attention. China possess abundant horse breed resources, particularly Guizhou horses, which play vital roles in local agriculture, tourism, and transportation. Despite this, there is a lack of comparative studies on the gut microbiota of native Guizhou horses (GZH) and imported Dutch Warmblood horses (WH). To address this gap, fecal samples were collected from both GZH and WH, and 16S rRNA high-throughput sequencing was utilized to analyze the differences in their gut microbiota. The results indicated that compared with GZH, the abundance of the gut bacterial community in WH was significantly higher, whereas the abundance of the gut fungal community was lower. Furthermore, PCoA-based scatter plot analysis demonstrated distinct differences in the structure of gut bacteria and fungi between the two breeds. While both types of horses share similar major bacterial and fungal phyla, significant differences were observed in numerous bacterial and fungal genera. Moreover, functional predictions of gut bacterial communities suggested that WH exhibit a more robust digestive system and enhanced glycan biosynthesis and metabolism capabilities. This is the first report on the comparative analysis of the gut microbiota in GZH and WH. The results emphasize the significant differences in gut microbiota among various horse breeds and offer valuable insights into the composition and structure of gut microbiota in different horse breeds.
Copyright © 2025 Lan, Li and Wang.
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Publication Date: 2025-03-12 PubMed ID: 40143867PubMed Central: PMC11936890DOI: 10.3389/fmicb.2025.1562482Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study compares the gut microbiota in Guizhou horses from China and Dutch Warmblood horses, using fecal samples and high-throughput sequencing. It is found that the bacterial communities in Dutch Warmblood horses are more abundant, but their fungal communities are fewer than those in Guizhou horses. The differences in gut microbiota may be linked to variations in digestive system strength and glycan production.

Methodology

  • The researchers used 16S rRNA high-throughput sequencing to examine the gut microbiota of two distinct horse breeds, the native Guizhou horses (GZH) and Dutch Warmblood horses (WH).
  • Fecal samples were collected and analysed from both horse breeds. This approach offered a non-invasive way to collect the samples, and the fecal samples provided insights into the gut microbiota.

Results

  • It was discovered that the Dutch Warmblood horses (WH) had a significantly higher abundance of gut bacterial communities compared to the Guizhou horses (GZH). On the contrary, the gut fungal community was lower in WH.
  • PCoA-based scatter plot analysis revealed clear distinctions in the structure of gut bacteria and fungi between the two horse breeds, suggesting variations in the gut microbiota biodiversity.
  • Whilst both horse breeds share similar dominant bacterial and fungal phyla, notable differences were identified in various bacterial and fungal genera.

Functional Predictions

  • The functional predictions of gut bacterial communities proposed that WH horses might have superior digestive capabilities and increased glycan biosynthesis and metabolism.
  • This finding contributes to understanding the role of gut microbiota in the overall health and digestive process of horse breeds.

Conclusion

  • This is the inaugural study to compare the gut microbiota of GZH and WH. The results highlight the significant disparities in gut microbiota across different horse breeds.
  • The findings provide valuable insights into the composition and structure of gut microbiota in diverse horse breeds and emphasize the influence of varying gut bacteria and fungi on horse health and physiology.

Cite This Article

APA
Lan Y, Li Y, Wang Y. (2025). Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses. Front Microbiol, 16, 1562482. https://doi.org/10.3389/fmicb.2025.1562482

Publication

Frontiers in microbiology
ISSN: 1664-302X
NlmUniqueID: 101548977
Country: Switzerland
Language: English
Volume: 16
Pages: 1562482

Researcher Affiliations

Lan, Yanfang
  • School of Physical Education and National Equestrian Academy, Wuhan Business University, Wuhan, China.
Li, Yaonan
  • School of Physical Education and National Equestrian Academy, Wuhan Business University, Wuhan, China.
Wang, Yang
  • School of Physical Education and National Equestrian Academy, Wuhan Business University, Wuhan, China.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

This article includes 64 references
  1. Bao P, Zhang Z, Liang Y, Yu Z, Xiao Z, Wang Y. Role of the gut microbiota in glucose metabolism during heart failure. Front. Cardiovasc. Med. 2022;9:903316.
    doi: 10.3389/fcvm.2022.903316pmc: PMC9289393pubmed: 35859583google scholar: lookup
  2. Beaumont M, Mussard E, Barilly C, Lencina C, Gress L, Painteaux L. Developmental stage, solid food introduction, and suckling cessation differentially influence the comaturation of the gut microbiota and intestinal epithelium in rabbits. J. Nutr. 2022;152:723–736.
    doi: 10.1093/jn/nxab411pmc: PMC8891179pubmed: 34875085google scholar: lookup
  3. Bellerba F, Muzio V, Gnagnarella P, Facciotti F, Chiocca S, Bossi P. The association between vitamin d and gut microbiota: a systematic review of human studies. Nutrients 2021;13:3378.
    doi: 10.3390/nጐ3378pmc: PMC8540279pubmed: 34684379google scholar: lookup
  4. Bo T B, Wen J, Zhao Y C, Tian S J, Zhang X Y, Wang D H. Bifidobacterium pseudolongum reduces triglycerides by modulating gut microbiota in mice fed high-fat food. J. Steroid Biochem. Mol. Biol. 2020;198:105602.
    doi: 10.1016/j.jsbmb.2020.105602pubmed: 31987886google scholar: lookup
  5. Cheng H Y, Ning M X, Chen D K, Ma W T. Interactions between the gut microbiota and the host innate immune response against pathogens. Front. Immunol. 2019;10:607.
    doi: 10.3389/fimmu.2019.00607pmc: PMC6449424pubmed: 30984184google scholar: lookup
  6. Cheng Y, Song W, Tian H, Zhang K, Li B, Du Z. The effects of high-density polyethylene and polypropylene microplastics on the soil and earthworm metaphire guillelmi gut microbiota. Chemosphere 2021;267:129219.
    doi: 10.1016/j.chemosphere.2020.129219pubmed: 33321277google scholar: lookup
  7. Cheng J, Xue F, Zhang M, Cheng C, Qiao L, Ma J. Trim 31 deficiency is associated with impaired glucose metabolism and disrupted gut microbiota in mice. Front. Physiol. 2018;9:24.
    doi: 10.3389/fphys.2018.00024pmc: PMC5818424pubmed: 29497383google scholar: lookup
  8. Chu J, Wang Y, Zhao B, Zhang X M, Liu K, Mao L. Isolation and identification of new antibacterial compounds from bacillus pumilus. Appl. Microbiol. Biotechnol. 2019;103:8375–8381.
    doi: 10.1007/s00253-019-10083-ypubmed: 31444521google scholar: lookup
  9. de Clercq N C, Groen A K, Romijn J A, Nieuwdorp M. Gut microbiota in obesity and undernutrition. Adv. Nutr. 2016;7:1080–1089.
    doi: 10.3945/an.116.012914pmc: PMC5105041pubmed: 28140325google scholar: lookup
  10. Deepthi M, Arvind K, Saxena R, Pulikkan J, Sharma V K, Grace T. Exploring variation in the fecal microbial communities of Kasaragod dwarf and Holstein crossbred cattle. Antonie Van Leeuwenhoek 2023;116:53–65.
    doi: 10.1007/s10482-022-01791-zpubmed: 36450879google scholar: lookup
  11. Di Pietro R, Arroyo L G, Leclere M, Costa M C. Species-level gut microbiota analysis after antibiotic-induced dysbiosis in horses. Animals 2021;11:2859.
    doi: 10.3390/ani11102859pmc: PMC8533001pubmed: 34679880google scholar: lookup
  12. Dong Z X, Chen Y F, Li H Y, Tang Q H, Guo J. The succession of the gut microbiota in insects: a dynamic alteration of the gut microbiota during the whole life cycle of honey bees (apis cerana). Front. Microbiol. 2021;12:513962.
    doi: 10.3389/fmicb.2021.513962pmc: PMC8079811pubmed: 33935980google scholar: lookup
  13. Du Z, Li J, Li W, Fu H, Ding J, Ren G. Effects of prebiotics on the gut microbiota in vitro associated with functional diarrhea in children. Front. Microbiol. 2023;14:1233840.
    doi: 10.3389/fmicb.2023.1233840pmc: PMC10502507pubmed: 37720150google scholar: lookup
  14. Gophna U, Konikoff T, Nielsen H B. Oscillospira and related bacteria – from metagenomic species to metabolic features. Environ. Microbiol. 2017;19:835–841.
    doi: 10.1111/1462-2920.13658pubmed: 28028921google scholar: lookup
  15. Guan X, Zhu J, Yi L, Sun H, Yang M, Huang Y. Comparison of the gut microbiota and metabolites between diannan small ear pigs and diqing tibetan pigs. Front. Microbiol. 2023;14:1197981.
    doi: 10.3389/fmicb.2023.1197981pmc: PMC10359432pubmed: 37485506google scholar: lookup
  16. Guo W, Zhou X, Li X, Zhu Q, Peng J, Zhu B. Depletion of gut microbiota impairs gut barrier function and antiviral immune defense in the liver. Front. Immunol. 2021;12:636803.
    doi: 10.3389/fimmu.2021.636803pmc: PMC8027085pubmed: 33841420google scholar: lookup
  17. Hao Z, Wang X, Yang H, Tu T, Zhang J, Luo H. Pul-mediated plant cell wall polysaccharide utilization in the gut bacteroidetes. Int. J. Mol. Sci. 2021;22:3077.
    doi: 10.3390/ijms22063077pmc: PMC8002723pubmed: 33802923google scholar: lookup
  18. Hasain Z, Mokhtar N M, Kamaruddin N A, Mohamed I N, Razalli N H, Gnanou J V. Gut microbiota and gestational diabetes mellitus: a review of host-gut microbiota interactions and their therapeutic potential. Front. Cell. Infect. Microbiol. 2020;10:188.
    doi: 10.3389/fcimb.2020.00188pmc: PMC7243459pubmed: 32500037google scholar: lookup
  19. Hong Y S, Jung D H, Chung W H, Nam Y D, Kim Y J, Seo D H. Human gut commensal bacterium ruminococcus species fmb-cy1 completely degrades the granules of resistant starch. Food Sci. Biotechnol. 2022;31:231–241.
    doi: 10.1007/s10068-021-01027-2pmc: PMC8818079pubmed: 35186353google scholar: lookup
  20. Horng Y B, Yu Y H, Dybus A, Hsiao F S, Cheng Y H. Antibacterial activity of bacillus species-derived surfactin on brachyspira hyodysenteriae and clostridium perfringens. AMB Express 2019;9:188.
    doi: 10.1186/s13568-019-0914-2pmc: PMC6872690pubmed: 31754906google scholar: lookup
  21. Huang S, Chen J, Cui Z, Ma K, Wu D, Luo J. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus. Sci. Adv. 2023;9:i7337: eadi7337.
    doi: 10.1126/sciadv.adi7337pmc: PMC10624355pubmed: 37922350google scholar: lookup
  22. Huang Y, Shi X, Li Z, Shen Y, Shi X, Wang L. Possible association of firmicutes in the gut microbiota of patients with major depressive disorder. Neuropsychiatr. Dis. Treat. 2018;14:3329–3337.
    doi: 10.2147/NDT.S188340pmc: PMC6284853pubmed: 30584306google scholar: lookup
  23. Hubert S M, Al-Ajeeli M, Bailey C A, Athrey G. The role of housing environment and dietary protein source on the gut microbiota of chicken. Animals 2019;9:1085.
    doi: 10.3390/ani9121085pmc: PMC6940977pubmed: 31817422google scholar: lookup
  24. Jian Y, Xu Z, Xu C, Zhang L, Sun X, Yang D. The roles of glycans in bladder cancer. Front. Oncol. 2020;10:957.
    doi: 10.3389/fonc.2020.00957pmc: PMC7303958pubmed: 32596162google scholar: lookup
  25. Jiang J W, Chen X H, Ren Z, Zheng S S. Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis. Hepatob. Pancreatic. Dis. Int. 2019;18:19–27.
    doi: 10.1016/j.hbpd.2018.11.002pubmed: 30527903google scholar: lookup
  26. Jin Y, Li W, Ba X, Li Y, Wang Y, Zhang H. Gut microbiota changes in horses with chlamydia. BMC Microbiol. 2023;23:246.
    doi: 10.1186/s12866-023-02986-8pmc: PMC10474637pubmed: 37660043google scholar: lookup
  27. Kim H S, Whon T W, Sung H, Jeong Y S, Jung E S, Shin N R. Longitudinal evaluation of fecal microbiota transplantation for ameliorating calf diarrhea and improving growth performance. Nat. Commun. 2021;12:161.
    doi: 10.1038/s41467-020-20389-5pmc: PMC7794225pubmed: 33420064google scholar: lookup
  28. Li Y, Lan Y, Zhang S, Wang X. Comparative analysis of gut microbiota between healthy and diarrheic horses. Front. Vet. Sci. 2022;9:882423.
    doi: 10.3389/fvets.2022.882423pmc: PMC9108932pubmed: 35585860google scholar: lookup
  29. Li Z, Xiong W, Liang Z, Wang J, Zeng Z, Kolat D. Critical role of the gut microbiota in immune responses and cancer immunotherapy. J. Hematol. Oncol. 2024;17:33.
    doi: 10.1186/s13045-024-01541-wpmc: PMC11094969pubmed: 38745196google scholar: lookup
  30. Li D, Yang H, Li Q, Ma K, Wang H, Wang C. Prickly ash seeds improve immunity of hu sheep by changing the diversity and structure of gut microbiota. Front. Microbiol. 2023;14:1273714.
    doi: 10.3389/fmicb.2023.1273714pmc: PMC10644117pubmed: 38029081google scholar: lookup
  31. Li S, Zhu S, Yu J. The role of gut microbiota and metabolites in cancer chemotherapy. J. Adv. Res. 2023;64:223–235.
    doi: 10.1016/j.jare.2023.11.027pmc: PMC11464465pubmed: 38013112google scholar: lookup
  32. Lim H J, Shin H S. Antimicrobial and immunomodulatory effects of bifidobacterium strains: a review. J. Microbiol. Biotechnol. 2020;30:1793–1800.
    doi: 10.4014/jmb.2007.07046pmc: PMC9728261pubmed: 33144551google scholar: lookup
  33. Liu X, Fan P, Che R, Li H, Yi L, Zhao N. Fecal bacterial diversity of wild Sichuan snub-nosed monkeys (rhinopithecus roxellana). Am. J. Primatol. 2018;80:e22753.
    doi: 10.1002/ajp.22753pubmed: 29635791google scholar: lookup
  34. Ma J, Chen J, Gan M, Chen L, Zhao Y, Zhu Y. Gut microbiota composition and diversity in different commercial swine breeds in early and finishing growth stages. Animals 2022;12:1607.
    doi: 10.3390/ani12131607pmc: PMC9264831pubmed: 35804507google scholar: lookup
  35. Mach N, Foury A, Kittelmann S, Reigner F, Moroldo M, Ballester M. The effects of weaning methods on gut microbiota composition and horse physiology. Front. Physiol. 2017;8:535.
    doi: 10.3389/fphys.2017.00535pmc: PMC5524898pubmed: 28790932google scholar: lookup
  36. Mach N, Ruet A, Clark A, Bars-Cortina D, Ramayo-Caldas Y, Crisci E. Priming for welfare: gut microbiota is associated with equitation conditions and behavior in horse athletes. Sci. Rep. 2020;10:8311.
    doi: 10.1038/s41598-020-65444-9pmc: PMC7239938pubmed: 32433513google scholar: lookup
  37. Massacci F R, Clark A, Ruet A, Lansade L, Costa M, Mach N. Inter-breed diversity and temporal dynamics of the faecal microbiota in healthy horses. J. Anim. Breed. Genet. 2020;137:103–120.
    doi: 10.1111/jbg.12441pubmed: 31523867google scholar: lookup
  38. Mazanko M S, Popov I V, Prazdnova E V, Refeld A G, Bren A B, Zelenkova G A. Beneficial effects of spore-forming bacillus probiotic bacteria isolated from poultry microbiota on broilers' health, growth performance, and immune system. Front. Vet. Sci. 2022;9:877360.
    doi: 10.3389/fvets.2022.877360pmc: PMC9194945pubmed: 35711797google scholar: lookup
  39. Meng Z, Liu L, Yan S, Sun W, Jia M, Tian S. Gut microbiota: a key factor in the host health effects induced by pesticide exposure?. J. Agric. Food Chem. 2020;68:10517–10531.
    doi: 10.1021/acs.jafc.0c04678pubmed: 32902962google scholar: lookup
  40. Park T, Yoon J, Kim A, Unno T, Yun Y. Comparison of the gut microbiota of jeju and thoroughbred horses in Korea. Vet. Sci. 2021;8:81.
    doi: 10.3390/vetsci8050081pmc: PMC8151153pubmed: 34064714google scholar: lookup
  41. Purushothaman A, Mohajeri M, Lele T P. The role of glycans in the mechanobiology of cancer. J. Biol. Chem. 2023;299:102935.
    doi: 10.1016/j.jbc.2023.102935pmc: PMC9930169pubmed: 36693448google scholar: lookup
  42. Quintanilla-Pineda M, Ibanez F C, Garrote-Achou C, Marzo F. A novel postbiotic product based on Weissella cibaria for enhancing disease resistance in rainbow trout: aquaculture application. Animals 2024;14:744.
    doi: 10.3390/ani14050744pmc: PMC10930836pubmed: 38473129google scholar: lookup
  43. Ravachol J, Borne R, Meynial-Salles I, Soucaille P, Pages S, Tardif C. Combining free and aggregated cellulolytic systems in the cellulosome-producing bacterium ruminiclostridium cellulolyticum. Biotechnol. Biofuels 2015;8:114.
    doi: 10.1186/s13068-015-0301-4pmc: PMC4533799pubmed: 26269713google scholar: lookup
  44. Santos-Marcos J A, Rangel-Zuniga O A, Jimenez-Lucena R, Quintana-Navarro G M, Garcia-Carpintero S, Malagon M M. Influence of gender and menopausal status on gut microbiota. Maturitas 2018;116:43–53.
    doi: 10.1016/j.maturitas.2018.07.008pubmed: 30244778google scholar: lookup
  45. Singh V, Rao A. Distribution and diversity of glycocin biosynthesis gene clusters beyond firmicutes. Glycobiology 2021;31:89–102.
    doi: 10.1093/glycob/cwaa061pubmed: 32614945google scholar: lookup
  46. Stanislawczyk R, Rudy M, Gil M, Duma-Kocan P, Zurek J. Influence of horse age, marinating substances, and frozen storage on horse meat quality. Animals 2021;11:2666.
    doi: 10.3390/ani11092666pmc: PMC8472284pubmed: 34573630google scholar: lookup
  47. Sun F, Chen J, Liu K, Tang M, Yang Y. The avian gut microbiota: diversity, influencing factors, and future directions. Front. Microbiol. 2022;13:934272.
    doi: 10.3389/fmicb.2022.934272pmc: PMC9389168pubmed: 35992664google scholar: lookup
  48. Sun B, Hou L, Yang Y. Effects of adding eubiotic lignocellulose on the growth performance, laying performance, gut microbiota, and short-chain fatty acids of two breeds of hens. Front. Vet. Sci. 2021;8:668003.
    doi: 10.3389/fvets.2021.668003pmc: PMC8473647pubmed: 34589531google scholar: lookup
  49. Tavella T, Rampelli S, Guidarelli G, Bazzocchi A, Gasperini C, Pujos-Guillot E. Elevated gut microbiome abundance of christensenellaceae, porphyromonadaceae and rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly. Gut Microbes 2021;13:1–19.
    doi: 10.1080/19490976.2021.1880221pmc: PMC7889099pubmed: 33557667google scholar: lookup
  50. Tizabi Y, Bennani S, El K N, Getachew B, Aschner M. Interaction of heavy metal lead with gut microbiota: implications for autism spectrum disorder. Biomol. Ther. 2023;13:1549.
    doi: 10.3390/biom13101549pmc: PMC10605213pubmed: 37892231google scholar: lookup
  51. Velikonja A, Lipoglavsek L, Zorec M, Orel R, Avgustin G. Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development. Anaerobe 2019;55:67–77.
    doi: 10.1016/j.anaerobe.2018.11.002pubmed: 30396006google scholar: lookup
  52. Wang S, Wang L, Fan X, Yu C, Feng L, Yi L. An insight into diversity and functionalities of gut microbiota in insects. Curr. Microbiol. 2020;77:1976–1986.
    doi: 10.1007/s00284-020-02084-2pubmed: 32535651google scholar: lookup
  53. Wang Z, Zeng X, Zhang C, Wang Q, Zhang W, Xie J. Higher niacin intakes improve the lean meat rate of ningxiang pigs by regulating lipid metabolism and gut microbiota. Front. Nutr. 2022;9:959039.
    doi: 10.3389/fnut.2022.959039pmc: PMC9582987pubmed: 36276825google scholar: lookup
  54. Wei X, Bottoms K A, Stein H H, Blavi L, Bradley C L, Bergstrom J. Dietary organic acids modulate gut microbiota and improve growth performance of nursery pigs. Microorganisms 2021;9:110.
    doi: 10.3390/microorganisms9010110pmc: PMC7824888pubmed: 33466376google scholar: lookup
  55. Wijnberg I D, Franssen H, van der Kolk J H. Influence of age of horse on results of quantitative electromyographic needle examination of skeletal muscles in Dutch warmblood horses. Am. J. Vet. Res. 2003;64:70–75.
    doi: 10.2460/ajvr.2003.64.70pubmed: 12518881google scholar: lookup
  56. Yang Y, Zhu Q, Liu S, Zhao C, Wu C. The origin of Chinese domestic horses revealed with novel mtdna variants. Anim. Sci. J. 2017;88:19–26.
    doi: 10.1111/asj.12583pubmed: 27071843google scholar: lookup
  57. Zhang J, Liang X, Tian X, Zhao M, Mu Y, Yi H. Bifidobacterium improves oestrogen-deficiency-induced osteoporosis in mice by modulating intestinal immunity. Food Funct. 2024;15:1840–1851.
    doi: 10.1039/d3fo05212epubmed: 38273734google scholar: lookup
  58. Zhang S, Shen Y, Wang S, Lin Z, Su R, Jin F. Responses of the gut microbiota to environmental heavy metal pollution in tree sparrow (passer montanus) nestlings. Ecotox. Environ. Safe. 2023;264:115480.
    doi: 10.1016/j.ecoenv.2023.115480pubmed: 37716068google scholar: lookup
  59. Zhang Y, Tan P, Zhao Y, Ma X. Enterotoxigenic Escherichia coli: intestinal pathogenesis mechanisms and colonization resistance by gut microbiota. Gut Microbes 2022;14:2055943.
    doi: 10.1080/19490976.2022.2055943pmc: PMC8973357pubmed: 35358002google scholar: lookup
  60. Zhang Z, Tanaka I, Pan Z, Ernst P B, Kiyono H, Kurashima Y. Intestinal homeostasis and inflammation: gut microbiota at the crossroads of pancreas-intestinal barrier axis. Eur. J. Immunol. 2022;52:1035–1046.
    doi: 10.1002/eji.202149532pmc: PMC9540119pubmed: 35476255google scholar: lookup
  61. Zhang N, Wang L, Wei Y. Effects of Bacillus pumilus on growth performance, immunological indicators and gut microbiota of mice. J. Anim. Physiol. Anim. Nutr. 2021;105:797–805.
    doi: 10.1111/jpn.13505pubmed: 33675272google scholar: lookup
  62. Zhu Y, Cidan Y, Sun G, Li X, Shahid M A, Luosang Z. Comparative analysis of gut fungal composition and structure of the yaks under different feeding models. Front. Vet. Sci. 2023;10:1193558.
    doi: 10.3389/fvets.2023.1193558pmc: PMC10310795pubmed: 37396992google scholar: lookup
  63. Zhuang X, Liu C, Zhan S, Tian Z, Li N, Mao R. Gut microbiota profile in pediatric patients with inflammatory bowel disease: a systematic review. Front. Pediatr. 2021;9:626232.
    doi: 10.3389/fped.2021.626232pmc: PMC7884334pubmed: 33604319google scholar: lookup
  64. Zuo T, Ng S C. The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease. Front. Microbiol. 2018;9:2247.
    doi: 10.3389/fmicb.2018.02247pmc: PMC6167487pubmed: 30319571google scholar: lookup

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