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Frontiers in microbiology2025; 16; 1562482; doi: 10.3389/fmicb.2025.1562482

Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses.

Abstract: In recent years, the importance of gut microbiota in digestive absorption, metabolism, and immunity has garnered increasing attention. China possess abundant horse breed resources, particularly Guizhou horses, which play vital roles in local agriculture, tourism, and transportation. Despite this, there is a lack of comparative studies on the gut microbiota of native Guizhou horses (GZH) and imported Dutch Warmblood horses (WH). To address this gap, fecal samples were collected from both GZH and WH, and 16S rRNA high-throughput sequencing was utilized to analyze the differences in their gut microbiota. The results indicated that compared with GZH, the abundance of the gut bacterial community in WH was significantly higher, whereas the abundance of the gut fungal community was lower. Furthermore, PCoA-based scatter plot analysis demonstrated distinct differences in the structure of gut bacteria and fungi between the two breeds. While both types of horses share similar major bacterial and fungal phyla, significant differences were observed in numerous bacterial and fungal genera. Moreover, functional predictions of gut bacterial communities suggested that WH exhibit a more robust digestive system and enhanced glycan biosynthesis and metabolism capabilities. This is the first report on the comparative analysis of the gut microbiota in GZH and WH. The results emphasize the significant differences in gut microbiota among various horse breeds and offer valuable insights into the composition and structure of gut microbiota in different horse breeds.
Copyright © 2025 Lan, Li and Wang.
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Publication Date: 2025-03-12 PubMed ID: 40143867PubMed Central: PMC11936890DOI: 10.3389/fmicb.2025.1562482Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study compares the gut microbiota in Guizhou horses from China and Dutch Warmblood horses, using fecal samples and high-throughput sequencing. It is found that the bacterial communities in Dutch Warmblood horses are more abundant, but their fungal communities are fewer than those in Guizhou horses. The differences in gut microbiota may be linked to variations in digestive system strength and glycan production.

Methodology

  • The researchers used 16S rRNA high-throughput sequencing to examine the gut microbiota of two distinct horse breeds, the native Guizhou horses (GZH) and Dutch Warmblood horses (WH).
  • Fecal samples were collected and analysed from both horse breeds. This approach offered a non-invasive way to collect the samples, and the fecal samples provided insights into the gut microbiota.

Results

  • It was discovered that the Dutch Warmblood horses (WH) had a significantly higher abundance of gut bacterial communities compared to the Guizhou horses (GZH). On the contrary, the gut fungal community was lower in WH.
  • PCoA-based scatter plot analysis revealed clear distinctions in the structure of gut bacteria and fungi between the two horse breeds, suggesting variations in the gut microbiota biodiversity.
  • Whilst both horse breeds share similar dominant bacterial and fungal phyla, notable differences were identified in various bacterial and fungal genera.

Functional Predictions

  • The functional predictions of gut bacterial communities proposed that WH horses might have superior digestive capabilities and increased glycan biosynthesis and metabolism.
  • This finding contributes to understanding the role of gut microbiota in the overall health and digestive process of horse breeds.

Conclusion

  • This is the inaugural study to compare the gut microbiota of GZH and WH. The results highlight the significant disparities in gut microbiota across different horse breeds.
  • The findings provide valuable insights into the composition and structure of gut microbiota in diverse horse breeds and emphasize the influence of varying gut bacteria and fungi on horse health and physiology.

Cite This Article

APA
Lan Y, Li Y, Wang Y. (2025). Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses. Front Microbiol, 16, 1562482. https://doi.org/10.3389/fmicb.2025.1562482

Publication

Frontiers in microbiology
ISSN: 1664-302X
NlmUniqueID: 101548977
Country: Switzerland
Language: English
Volume: 16
Pages: 1562482

Researcher Affiliations

Lan, Yanfang
  • School of Physical Education and National Equestrian Academy, Wuhan Business University, Wuhan, China.
Li, Yaonan
  • School of Physical Education and National Equestrian Academy, Wuhan Business University, Wuhan, China.
Wang, Yang
  • School of Physical Education and National Equestrian Academy, Wuhan Business University, Wuhan, China.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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