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International journal of molecular sciences2022; 23(15); 8655; doi: 10.3390/ijms23158655

Mitochondrial Dysfunctions and Potential Molecular Markers in Sport Horses.

Abstract: Mitochondria are an essential part of most eukaryotic cells. The crucial role of these organelles is the production of metabolic energy, which is converted into ATP in oxidative phosphorylation. They are also involved in and constitute apoptosis, the site of many metabolic processes. Some of the factors that negatively affect mitochondria are stress, excessive exercise, disease, and the aging process. Exercise can cause the release of large amounts of free radicals, inflammation, injury, and stress. All of these factors can contribute to mitochondrial dysfunction, which can consistently lead to inflammatory responses, tissue damage, organ dysfunction, and a host of diseases. The functions of the mitochondria and the consequences of their disturbance can be of great importance in the breeding and use of horses. The paper reviews mitochondrial disorders in horses and, based on the literature, indicates genetic markers strongly related to this issue.
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Publication Date: 2022-08-04 PubMed ID: 35955789PubMed Central: PMC9369138DOI: 10.3390/ijms23158655Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the role of mitochondria in equestrian health, specifically under the influence of exercise-induced stress and aging. The paper outlines potential genetic markers that could indicate mitochondrial dysfunction, contributing to inflammatory responses and diseases in sport horses.

Understanding Mitochondria and its Functions

  • Mitochondria are critical components of most eukaryotic cells, with their primary function being the production of metabolic energy. This energy is then converted into ATP (Adenosine Triphosphate) via oxidative phosphorylation.
  • Apart from producing energy, mitochondria are also involved in apoptosis, or the natural process of cell death, and serve as the site for various other metabolic processes.

Negative Influences on Mitochondrial Function

  • The paper identifies factors such as stress, excessive exercise, diseases, and aging as detrimental to mitochondrial function. In sports horses, continuous exertion can lead to the release of large quantities of free radicals, inflammation, and injury, contributing to stress.
  • All listed issues can foster mitochondrial dysfunction and potentiate the onset of diseases. The dysfunction can trigger inflammatory responses, tissue damage, and organ dysfunction, which can significantly impact the horse’s health and performance.

Impact of Mitochondrial Dysfunction on Horse Breeding and Use

  • The importance of understanding, identifying, and managing mitochondrial disturbances is emphasized for horse breeding and performance. Mitochondrial function can directly influence a horse’s vitality, performance capability, and overall health, making it a crucial consideration factor.

Genetic Markers Related to Mitochondrial Disorders

  • This paper explores potential genetic markers that could signify a risk for mitochondrial disorders. By identifying these genetic markers, breeders and equestrian caretakers can better predict and manage potential health risks, contributing to the longevity and performance of the horse.

Cite This Article

APA
Dzięgielewska A, Dunislawska A. (2022). Mitochondrial Dysfunctions and Potential Molecular Markers in Sport Horses. Int J Mol Sci, 23(15), 8655. https://doi.org/10.3390/ijms23158655

Publication

International journal of molecular sciences
ISSN: 1422-0067
NlmUniqueID: 101092791
Country: Switzerland
Language: English
Volume: 23
Issue: 15
PII: 8655

Researcher Affiliations

Dzięgielewska, Agnieszka
  • Department of Animal Biotechnology and Genetics, Bydgoszcz University of Science and Technology, Mazowiecka 28, 85-084 Bydgoszcz, Poland.
Dunislawska, Aleksandra
  • Department of Animal Biotechnology and Genetics, Bydgoszcz University of Science and Technology, Mazowiecka 28, 85-084 Bydgoszcz, Poland.

MeSH Terms

  • Animals
  • Biomarkers / metabolism
  • Horses
  • Mitochondria / genetics
  • Mitochondria / metabolism
  • Mitochondrial Diseases / metabolism
  • Oxidative Phosphorylation
  • Oxidative Stress / physiology

Conflict of Interest Statement

The authors declare no conflict of interest.

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