Monocyte activation in horses persistently infected with equine infectious anemia virus.
Abstract: The monocytes of horses infected with equine infectious anemia virus were shown by their failure to migrate from capillary tubes and their increased adherence to erythrocytes to be activated.
Publication Date: 1975-11-01 PubMed ID: 172455PubMed Central: PMC415420DOI: 10.1128/iai.12.5.1219-1221.1975Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research focuses on examining the activation of monocytes in horses infected with the equine infectious anemia virus. The study provides evidence of activation through the monocytes’ unusual behaviors, such as inability to migrate from capillary tubes and heightened adherence to erythrocytes.
Research Overview
- Researchers conducted a study to reflect upon the behavior of monocytes in horses that have been infected with the equine infectious anemia virus (EIAV).
- The study’s principal aim was to establish further knowledge of how the infection affects the monocytes, particularly in regard to their activation.
Methods and Procedure
- The team used capillary tubes to observe the monocytes’ ability to migrate.
- In addition to migration, they assessed the level of adherence of these monocytes to erythrocytes (red blood cells).
Results
- The findings demonstrated that the infected horses’ monocytes failed to migrate from the capillary tubes, indicating an irregular monocyte behavior.
- Equally significant was the observation that the monocytes showed increased adherence to erythrocytes.
Implications and Conclusions
- These uncharacteristic behaviors are indicative of monocyte activation, which transpires in response to an infection or inflammation.
- The study, therefore, unveils a particular manifestation of the equine infectious anemia virus on monocytes, contributing to a greater understanding of the virus’s impact and potentially informing future research and treatment approaches.
Cite This Article
APA
Banks KL.
(1975).
Monocyte activation in horses persistently infected with equine infectious anemia virus.
Infect Immun, 12(5), 1219-1221.
https://doi.org/10.1128/iai.12.5.1219-1221.1975 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cell Adhesion
- Cell Movement
- Equine Infectious Anemia / immunology
- Horses
- Infectious Anemia Virus, Equine / immunology
- Monocytes / immunology
- Neutrophils / immunology
References
This article includes 13 references
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- Huber H, Douglas SD, Fudenberg HH. The IgG receptor: an immunological marker for the characterization of mononuclear cells.. Immunology 1969 Jul;17(1):7-21.
- North RJ. Cellular kinetics associated with the development of acquired cellular resistance.. J Exp Med 1969 Aug 1;130(2):299-314.
- McLaughlin JF, Ruddle NH, Waksman BH. Relationship between activation of peritoneal cells and their cytopathogenicity.. J Reticuloendothel Soc 1972 Sep;12(3):293-304.
- McGuire TC, Henson JB, Quist SE. Viral-induced hemolysis in equine infectious anemia.. Am J Vet Res 1969 Dec;30(12):2091-7.
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Citations
This article has been cited 7 times.- Rodvold KA, Burgos RM, Tan X, Pai MP. Omadacycline: A Review of the Clinical Pharmacokinetics and Pharmacodynamics.. Clin Pharmacokinet 2020 Apr;59(4):409-425.
- Sellon DC. Equine infectious anemia.. Vet Clin North Am Equine Pract 1993 Aug;9(2):321-36.
- Sellon DC, Fuller FJ, McGuire TC. The immunopathogenesis of equine infectious anemia virus.. Virus Res 1994 May;32(2):111-38.
- Valpotić I, Kastelan M, Rudolf M, Gerencer M, Jukić B, Basić I. T and B lymphocytes in horses persistently infected with equine infectious anaemia virus.. Vet Res Commun 1989;13(1):57-65.
- Banks KL, Jutila MA, Jacobs CA, Michaels FH. Augmentation of lymphocyte and macrophage proliferation by caprine arthritis-encephalitis virus contributes to the development of progressive arthritis.. Rheumatol Int 1989;9(3-5):123-8.
- O'Rourke KI, Besola ML, McGuire TC. Proviral sequences detected by polymerase chain reaction in peripheral blood cells of horses with equine infectious anemia lentivirus.. Arch Virol 1991;117(1-2):109-19.
- Fujimiya Y, Perryman LE, Crawford TB. Leukocyte cytotoxicity in a persistent virus infection: presence of direct cytotoxicity but absence of antibody-dependent cellular cytotoxicity in horses infected with equine infectious anemia virus.. Infect Immun 1979 Jun;24(3):628-36.
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