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Home / Equine Research Bank / J Vet Med Sci / Morphometric changes in the aortic arch with advancing age i...
The Journal of veterinary medical science2017; 79(3); 661-669; doi: 10.1292/jvms.16-0600

Morphometric changes in the aortic arch with advancing age in fetal to mature thoroughbred horses.

Abstract: Aortic rupture is a well recognized cause of sudden death in thoroughbred horses. Some microscopic lesions, such as those caused by cystic medial necrosis and medionecrosis, can lead to aortic rupture. However, these microscopic lesions are also observed in normal horses. On the other hand, a previous study of aortic rupture suggested that underlying elastin and collagen deposition disorders might be associated with aortic rupture. Therefore, the purpose of this study was to compare the structural components of the tunica media of the aortic arch, which is composed of elastin, collagen, smooth muscle cells and mucopolysaccharides (MPS), in fetal to mature thoroughbred horses. The percentage area of elastin was greatest in the young horses and subsequently decreased with aging. The percentage area of collagen increased with aging, and the elderly horses (aged ≥20) exhibited significantly higher percentage areas of collagen than the young horses. The percentage area of smooth muscle cells did not change with age. The percentage area of MPS was inversely proportional to the percentage area of elastin. The fetuses exhibited a markedly larger percentage area of MPS than the mature horses. We concluded that the medial changes seen in the aortic arch, which included a reduction in the amount of elastin and increases in the amounts of collagen and MPS, were age-related variations.
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Publication Date: 2017-02-11 PubMed ID: 28190824PubMed Central: PMC5383194DOI: 10.1292/jvms.16-0600Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on structural changes in the aortic arch in thoroughbred horses from fetus to elderly age and analyzes these changes in correlation to certain causes of aortic rupture.

Objective of the research

  • The objective of this study is to examine and understand the structure of the aortic arch in thoroughbreds at different stages of life – from fetal to mature stages. The study focuses on the changes and composition of elastin, collagen, smooth muscle cells and mucopolysaccharides (MPS) in the aortic arch. This has been undertaken with the aim to gain insights into the causes of aortic rupture in horse breeds.

Methodology and Results

  • The researchers compared the structural components of the tunica media (the middle layer of the artery walls) of the aortic arch in various age groups of thoroughbreds.
  • It was observed that the area occupied by elastin was highest in younger horses and reduced with age.
  • The percentage area of collagen, on the other hand, increased with age, with elderly horses showing a relatively higher percentage area when compared to younger ones.
  • The area occupied by smooth muscle cells in the arch remained constant across all age groups.
  • The researchers found a negative correlation between the percentage area of MPS and elastin, which was substantiated by the considerable difference in the percentage area of MPS between fetuses and mature horses.

Conclusions

  • The reduction in the percentage area of elastin and the increase in the amount of collagen and MPS are attributed to be age-related variations in the aortic arch of thoroughbreds.
  • The study suggests these changes may contribute to the risk of aortic rupture as horses age. However, this correlation needs further research to establish a definite cause-effect relationship.

Cite This Article

APA
Endoh C, Matsuda K, Okamoto M, Tsunoda N, Taniyama H. (2017). Morphometric changes in the aortic arch with advancing age in fetal to mature thoroughbred horses. J Vet Med Sci, 79(3), 661-669. https://doi.org/10.1292/jvms.16-0600

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 79
Issue: 3
Pages: 661-669

Researcher Affiliations

Endoh, Chihiro
  • Department of Veterinary Pathology, Rakuno Gakuen University, 582 Midori-machi, Bunkyo-dai, Ebetsu, Hokkaido 069-8501, Japan.
Matsuda, Kazuya
    Okamoto, Minoru
      Tsunoda, Nobuo
        Taniyama, Hiroyuki

          MeSH Terms

          • Aging / metabolism
          • Animals
          • Aorta, Thoracic / anatomy & histology
          • Aorta, Thoracic / embryology
          • Aorta, Thoracic / growth & development
          • Collagen / metabolism
          • Elastin / metabolism
          • Glycosaminoglycans / metabolism
          • Horses / anatomy & histology
          • Horses / growth & development
          • Tunica Media / anatomy & histology
          • Tunica Media / embryology
          • Tunica Media / growth & development

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          Citations

          This article has been cited 1 times.
          1. Côté E, Zhang RM, Kaiser N, Reinhardt DP, Martin CK. Annuloaortic ectasia in a four-month-old male Newfoundland dog: long-term follow-up and immunofluorescent study. Vet Q 2021 Dec;41(1):280-291.
            doi: 10.1080/01652176.2021.1961039pubmed: 34607531google scholar: lookup
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