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Australian veterinary journal2022; 100(7); 336-341; doi: 10.1111/avj.13161

Multi-modality imaging of aggressive submural neoplasia of the hoof in two horses.

Abstract: This case series presents a 20-year-old Quarter horse gelding and a 10-year-old Thoroughbred gelding with a histologic diagnosis of aggressive submural neoplasia, including an anaplastic sarcoma and a squamous cell carcinoma respectively. The current case series describes these neoplasias with radiography, computed tomography, magnetic resonance imaging and histopathology with immunohistochemistry. The purpose of this case series is to identify the clinical pattern of chronic reoccurring lameness in these cases and highlight the appearance of expansile osteolytic pathology of the distal phalanx with adjacent hoof wall abnormalities. Advanced imaging has the potential to assist with a differential diagnosis list and surgical planning in patients such as these however obtaining a cellular sample for histopathological examination remains necessary for definitive diagnosis.
© 2022 Australian Veterinary Association.
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Publication Date: 2022-04-05 PubMed ID: 35781224DOI: 10.1111/avj.13161Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study presents two cases, a 20-year-old Quarter horse and a 10-year-old Thoroughbred, both diagnosed with aggressive submural neoplasia – an anaplastic sarcoma and a squamous cell carcinoma, respectively. The research used advanced imaging like radiography, computed tomography, MRI and histopathology to understand the cause of recurring lameness in the horses and identified a potential treatment approach.

Objective and Methodology

  • The purpose of the study was to understand the cause of chronic recurring lameness in horses, which was identified as aggressive submural neoplasia. Two cases were studied – a 20-year-old Quarter horse gelding and a 10-year-old Thoroughbred gelding who had been diagnosed with the disease.
  • The researchers used a variety of imaging modalities to examine the horses’ conditions, including radiography, computed tomography (CT), magnetic resonance imaging (MRI), and histopathology with immunohistochemistry. These advanced imaging techniques were used to observe the appearance of subsctructive pathology in the distal phalanx, an area near to the hoof wall of the horses.

Findings and Implications

  • The aggressiveness of submural neoplasia, typified by an anaplastic sarcoma in the Quarter horse and a squamous cell carcinoma in the Thoroughbred, resulted in expansive osteolytic pathology, which is a painful condition involving the loss of bone tissues of the distal phalanx. This was identified as the cause of chronic recurring lameness in these horses.
  • The study emphasized the appearance of hoof wall abnormalities adjacent to the area of bone loss. The researchers found that these anomalies could be detected using advanced imaging techniques. This realization has potential implications for the diagnosis and treatment strategies for such conditions in the future.
  • The use of advanced imaging in these cases not only helped to create a differential diagnosis list, but also contributed towards surgical planning for the horses. This shows how technology can assist in effectively managing such conditions. However, the scientists point out that a cellular sample for histopathological examination is still necessary for a definitive diagnosis of aggressive submural neoplasia.

Cite This Article

APA
Nagel H, Lang H, Sole Guitart A, Lean N, Allavena R, Sprohnle-Barrera C, Young A. (2022). Multi-modality imaging of aggressive submural neoplasia of the hoof in two horses. Aust Vet J, 100(7), 336-341. https://doi.org/10.1111/avj.13161

Publication

Australian veterinary journal
ISSN: 1751-0813
NlmUniqueID: 0370616
Country: England
Language: English
Volume: 100
Issue: 7
Pages: 336-341

Researcher Affiliations

Nagel, H
  • REC Equine Specialists, Horsley Park, New South Wales, Australia.
Lang, H
  • REC Equine Specialists, Horsley Park, New South Wales, Australia.
Sole Guitart, A
  • The University of Queensland - Gatton Campus, School of Veterinary Science, Gatton, Queensland, Australia.
Lean, N
  • The University of Queensland - Gatton Campus, School of Veterinary Science, Gatton, Queensland, Australia.
Allavena, R
  • The University of Queensland - Gatton Campus, School of Veterinary Science, Gatton, Queensland, Australia.
Sprohnle-Barrera, C
  • The University of Queensland - Gatton Campus, School of Veterinary Science, Gatton, Queensland, Australia.
Young, A
  • The University of Queensland - Gatton Campus, School of Veterinary Science, Gatton, Queensland, Australia.

MeSH Terms

  • Animals
  • Carcinoma, Squamous Cell / veterinary
  • Forelimb / pathology
  • Hoof and Claw / diagnostic imaging
  • Hoof and Claw / pathology
  • Horse Diseases / diagnosis
  • Horses
  • Lameness, Animal / diagnosis
  • Male
  • Multimodal Imaging

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Citations

This article has been cited 1 times.
  1. Bulnes F, Argüelles D, Buzón A, García-Álamo K, Rodríguez-Gómez IM, Hernández E, Mozos E. Concomitant melanoma and keratoma affecting the equine digit: clinical, pathological, and long-term follow-up findings. BMC Vet Res 2024 Oct 1;20(1):444.
    doi: 10.1186/s12917-024-04269-4pubmed: 39354566google scholar: lookup
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