FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / J Vet Intern Med / Multiple hypersensitivities including recurrent airway obstr...
Journal of veterinary internal medicine2014; 29(1); 320-326; doi: 10.1111/jvim.12473

Multiple hypersensitivities including recurrent airway obstruction, insect bite hypersensitivity, and urticaria in 2 warmblood horse populations.

Abstract: Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses. Objective: Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2-224511), previously shown to be associated with RAO. Methods: The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO-affected Warmblood horses and 264 RAO-unaffected controls. All horses were Warmbloods, 14 years or older. Methods: Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2-224511 as well as management and environmental factors were investigated. Results: In P1, RAO-affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH-affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces. Conclusions: This is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO-affected horses.
Copyright © 2014 by the American College of Veterinary Internal Medicine.
Get Full Text
Publication Date: 2014-09-30 PubMed ID: 25270534PubMed Central: PMC4858110DOI: 10.1111/jvim.12473Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the existence and related causes of Multiple hypersensitivities (MHS) in horses, specifically Warmblood breeds. The research finds a strong correlation between afflictions such as recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), and urticaria (URT) in these horses, as well as associations with decreased shedding of strongylid eggs and a specific genetic marker.

Research Aim

The primary aim of this research was to explore the possible existence of Multiple Hypersensitivities (MHS) in Warmblood horses. Previous studies recognized MHS in humans, cats, and dogs, but there was no established knowledge concerning horses. The researchers hypothesized that horses suffering from one hypersensitive condition like Recurrent Airway Obstruction (RAO), Insect Bite Hypersensitivity (IBH), or Urticaria (URT) carry an increased risk of being affected by another one of these hypersensitivities.

Methodology

  • The study used two populations of horses. The first population (P1) consisted of 119 randomly sampled horses representative of the Swiss sporthorse population. The replication population (P2) consisted of 210 RAO-affected Warmblood horses and 264 RAO-unaffected controls. All horses were Warmbloods, aged 14 years or older.
  • Associations were investigated between disease phenotypes (RAO, IBH, URT, MHS), fecal egg counts (focusing on the shedding of strongylid eggs), a specific single nucleotide polymorphism (SNP BIEC2-224511), as well as management and environmental factors.

Results

  • In the first population (P1), RAO-affected horses were 13.1 times more likely to also suffer from IBH. In the second population (P2), this odds ratio was 7.4.
  • In P2, horses with IBH also showed a 7.1 times increased likelihood of suffering from URT.
  • IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces, suggesting decreased shedding of these eggs for these horses.

Conclusions

The research concludes that there is evidence of Multiple Hypersensitivities (MHS) in horses, an insight that had not been previously reported. In particular, horses afflicted by Recurrent Airway Obstruction (RAO) showed an increase in risks for Insect Bite Hypersensitivity (IBH). Thus, it aids in better understanding the health and wellness of the Warmblood horse population, and the health treatments that could help such horses.

Cite This Article

APA
Kehrli D, Jandova V, Fey K, Jahn P, Gerber V. (2014). Multiple hypersensitivities including recurrent airway obstruction, insect bite hypersensitivity, and urticaria in 2 warmblood horse populations. J Vet Intern Med, 29(1), 320-326. https://doi.org/10.1111/jvim.12473

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 29
Issue: 1
Pages: 320-326

Researcher Affiliations

Kehrli, D
  • Swiss Institute of Equine Medicine, University of Berne and Agroscope, Berne, Switzerland.
Jandova, V
    Fey, K
      Jahn, P
        Gerber, V

          MeSH Terms

          • Animals
          • Data Collection
          • Europe / epidemiology
          • Female
          • Horse Diseases / epidemiology
          • Horse Diseases / immunology
          • Horses
          • Hypersensitivity / epidemiology
          • Hypersensitivity / immunology
          • Hypersensitivity / veterinary
          • Insect Bites and Stings / epidemiology
          • Insect Bites and Stings / immunology
          • Insect Bites and Stings / veterinary
          • Lung Diseases, Obstructive / epidemiology
          • Lung Diseases, Obstructive / veterinary
          • Male
          • Urticaria / epidemiology
          • Urticaria / immunology
          • Urticaria / veterinary

          References

          This article includes 36 references
          1. Leclere M, Lavoie‐Lamoureux A, Lavoie JP. Heaves, an asthma‐like disease of horses.. Respirology 2011;16:1027–1046.
            pubmed: 21824219
          2. Ramseyer A, Gaillard C, Burger D. Effects of genetic and environmental factors on chronic lower airway disease in horses.. J Vet Intern Med 2007;21:149–156.
            pubmed: 17338163
          3. Couëtil LL, Hoffman AM, Hodgson J. Inflammatory airway disease of horses.. J Vet Intern Med 2007;21:356–361.
            pubmed: 17427403
          4. Marti E, Gerber V, Wilson AD. Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hòlar, Iceland, June 2007.. Vet Immunol Immunopathol 2008;126:351–361.
            pubmed: 18775570
          5. Rüfenacht S, Marti E, von Tscharner C. Immunoglobulin E‐bearing cells and mast cells in skin biopsies of horses with urticaria.. Vet Dermatol 2005;16:94–101.
            pubmed: 15842539
          6. Lowell FC. Observations on heaves. An asthma‐like syndrome in the horse.. J Allergy 1964;35:322–330.
            pubmed: 14193184
          7. Carlotti D, Prost C. L'atopie féline.. Point Vét 1988;20:777–784.
          8. Olivry T, Hill PB. The ACVD task force on canine atopic dermatitis (IX): The controversy surrounding the route of allergen challenge in canine atopic dermatitis.. Vet Immunol Immunopathol 2001;81:219–225.
            pubmed: 11553383
          9. Kurt E, Demir AU, Cadirci O. Immediate‐type drug hypersensitivity and associated factors in a general population.. Allergol Immunopathol 2011;39:27–31.
            pubmed: 20675031
          10. Bottema RWB, Nolte IM, Howard TD. Interleukin 13 and interleukin 4 receptor‐α polymorphisms in rhinitis and asthma.. Int Arch Allergy Immunol 2010;153:259–267.
            pubmed: 20484924
          11. Bieber T. Atopic dermatitis.. Ann Dermatol 2010;22:125–137.
            pmc: PMC2883413pubmed: 20548901
          12. Spergel JM, Paller AS. Atopic dermatitis and the atopic march.. J Allergy Clin Immunol 2003;112:118–127.
            pubmed: 14657842
          13. Herszberg B, Ramos‐Barbón D, Tamaoka M. Heaves, an asthma‐like equine disease, involves airway smooth muscle remodeling.. J Allergy Clin Immunol 2006;118:382–388.
            pubmed: 16890762
          14. Robinson NE. Chairperson's introduction: International Workshop on Equine Chronic Airway Disease, Michigan State University, 16–18 June 2000.. Equine Vet J 2001;33:5–19.
            pubmed: 11191611
          15. Jost U, Klukowska‐Rötzler J, Dolf G. A region on equine chromosome 13 is linked to recurrent airway obstruction in horses.. Equine Vet J 2007;39:236–241.
            pubmed: 17520975
          16. Shakhsi‐Niaei M, Klukowska‐Rötzler J, Drögemüller C. Replication and fine‐mapping of a QTL for recurrent airway obstruction in European Warmblood horses.. Anim Genet 2012;43:627–631.
            pubmed: 22497545
          17. Bründler P, Frey CF, Gottstein B. Lower shedding of strongylid eggs by Warmblood horses with recurrent airway obstruction compared to unrelated healthy horses.. Vet J 2011;190:12–15.
            pubmed: 21315626
          18. Neuhaus S, Bründler P, Frey CF. Increased parasite resistance and recurrent airway obstruction in horses of a high‐prevalence family.. J Vet Intern Med 2010;24:407–413.
            pubmed: 20102498
          19. Strachan DP. Hay fever, hygiene, and household size.. BMJ 1989;299:1259–1260.
            pmc: PMC1838109pubmed: 2513902
          20. Ramseyer A, Gaillard C, Straub R. Clinical manifestation of recurrent airway obstruction (RAO) in a Swiss Warmblood family.. Proceedings of the Third World Equine Airways Symposium (WEAS) Cornell, NY, 2005.
          21. Gerber V, Baleri D, Klukowska‐Rötzler J. Mixed inheritance of equine recurrent airway obstruction.. J Vet Intern Med 2009;23:626–630.
            pubmed: 19645845
          22. Von Samson‐Himmelstjerna G. Helminthosen der Equiden. In: Schneider T, ed. Veterinärmedizinische Parasitologie, 6th ed Stuttgart, PA: Parey; 2006:303–347.
          23. Bauer C. Nachweis von Parasitenstadien im Kot. In: Schneider T, ed. Veterinärmedizinische Parasitologie, 6th ed Stuttgart, PA: Parey; 2006:88–96.
          24. Tamari M, Tanaka S, Hirota T. Genome‐wide association studies of allergic diseases.. Allergol Int 2013;62:21–28.
            pubmed: 28942987
          25. Moffatt MF, Gut IG, Demenais F. A large‐scale, consortium‐based genomewide association study of asthma.. N Engl J Med 2010;363:1211–1221.
            pmc: PMC4260321pubmed: 20860503
          26. Nair RP, Duffin KC, Helms C. Genome‐wide scan reveals association of psoriasis with IL‐23 and NF‐κB pathways.. Nat Genet 2009;41:199–204.
            pmc: PMC2745122pubmed: 19169254
          27. Scales HE, Ierna MX, Lawrence CE. The role of IL‐4, IL‐13 and IL‐4Ra in the development of protective and pathological responses to Trichinella spiralis .. Parasite Immunol 2007;29:81–91.
            pubmed: 17241396
          28. Baselgia S, Doherr MG, Mellor P. Evaluation of an in vitro sulphidoleukotriene release test for diagnosis of insect bite hypersensitivity in horses.. Equine Vet J 2006;38:40–46.
            pubmed: 16411585
          29. Mele M, Gerber V, Straub R. Prevalence of hereditary disease in three‐year‐old horses of the Freiberger breed.. Schweiz Arch Tierheilk 2007;149:151–159.
            pubmed: 17461390
          30. Studer S, Gerber V, Straub R. Prevalence of hereditary disease in three‐year‐old Swiss Warmblood horses.. Schweiz Arch Tierheilk 2007;149:161–171.
            pubmed: 17461391
          31. Halliwell REW. Efficacy of hyposensitization in feline allergic diseases based upon results of in vitro testing for allergen‐specific immunoglobulin E.. J Am Anim Hosp Assoc 1997;33:282–288.
            pubmed: 9138241
          32. Gilbert S, Prélaud P, Guaguère E. L'atopie féline.. Prat Méd Chir Anim Comp 1999;34:15–31.
          33. Hobi S, Linek M, Marignac G. Clinical characteristics and causes of pruritus in cats: A multicentre study on feline hypersensitivity‐associated dermatoses.. Vet Dermatol 2011;22:406–413.
            pubmed: 21410570
          34. Moriello KA, Stepien RL, Henik RA. Pilot study: Prevalence of positive aeroallergen reactions in 10 cats with small‐airway disease without concurrent skin disease.. Vet Dermatol 2007;18:94–100.
            pubmed: 17355423
          35. Marsella R, Sousa CA. The ACVD task force on canine atopic dermatitis (XIII): Threshold phenomenon and summation of effects.. Vet Immunol Immunopathol 2001;81:251–253.
            pubmed: 11553387
          36. Halliwell REW. The immunopathogenesis of allergic skin diseases in dogs and cats.. EJCAP 2009;19:213–218.
          Subscribe to our newsletter
          Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.