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Journal of veterinary internal medicine2014; 29(1); 320-326; doi: 10.1111/jvim.12473

Multiple hypersensitivities including recurrent airway obstruction, insect bite hypersensitivity, and urticaria in 2 warmblood horse populations.

Abstract: Multiple hypersensitivities (MHS) have been described in humans, cats, and dogs, but not horses. Objective: Horses suffering from recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), or urticaria (URT) will have an increased risk of also being affected by another one of these hypersensitivities. This predisposition for MHS also will be associated with decreased shedding of strongylid eggs in feces and with a single nucleotide polymorphism (SNP BIEC2-224511), previously shown to be associated with RAO. Methods: The first population (P1) included 119 randomly sampled horses representative of the Swiss sporthorse population; the replication population (P2) included 210 RAO-affected Warmblood horses and 264 RAO-unaffected controls. All horses were Warmbloods, 14 years or older. Methods: Associations between disease phenotypes (RAO, IBH, URT, MHS) fecal egg counts, the SNP BIEC2-224511 as well as management and environmental factors were investigated. Results: In P1, RAO-affected horses had a 13.1 times higher odds ratio (OR) of also suffering from IBH (P = .004). In P2, the respective OR was 7.4 (P = .002) and IBH-affected horses also showed a 7.1 times increased OR of concomitantly suffering from URT (P < .001). IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces. Conclusions: This is the first report of MHS in horses. Specifically, an increased risk for IBH should be expected in RAO-affected horses.
Copyright © 2014 by the American College of Veterinary Internal Medicine.
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Publication Date: 2014-09-30 PubMed ID: 25270534PubMed Central: PMC4858110DOI: 10.1111/jvim.12473Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the existence and related causes of Multiple hypersensitivities (MHS) in horses, specifically Warmblood breeds. The research finds a strong correlation between afflictions such as recurrent airway obstruction (RAO), insect bite hypersensitivity (IBH), and urticaria (URT) in these horses, as well as associations with decreased shedding of strongylid eggs and a specific genetic marker.

Research Aim

The primary aim of this research was to explore the possible existence of Multiple Hypersensitivities (MHS) in Warmblood horses. Previous studies recognized MHS in humans, cats, and dogs, but there was no established knowledge concerning horses. The researchers hypothesized that horses suffering from one hypersensitive condition like Recurrent Airway Obstruction (RAO), Insect Bite Hypersensitivity (IBH), or Urticaria (URT) carry an increased risk of being affected by another one of these hypersensitivities.

Methodology

  • The study used two populations of horses. The first population (P1) consisted of 119 randomly sampled horses representative of the Swiss sporthorse population. The replication population (P2) consisted of 210 RAO-affected Warmblood horses and 264 RAO-unaffected controls. All horses were Warmbloods, aged 14 years or older.
  • Associations were investigated between disease phenotypes (RAO, IBH, URT, MHS), fecal egg counts (focusing on the shedding of strongylid eggs), a specific single nucleotide polymorphism (SNP BIEC2-224511), as well as management and environmental factors.

Results

  • In the first population (P1), RAO-affected horses were 13.1 times more likely to also suffer from IBH. In the second population (P2), this odds ratio was 7.4.
  • In P2, horses with IBH also showed a 7.1 times increased likelihood of suffering from URT.
  • IBH, URT, and MHS phenotypes were significantly associated with the absence of nematode eggs in the feces, suggesting decreased shedding of these eggs for these horses.

Conclusions

The research concludes that there is evidence of Multiple Hypersensitivities (MHS) in horses, an insight that had not been previously reported. In particular, horses afflicted by Recurrent Airway Obstruction (RAO) showed an increase in risks for Insect Bite Hypersensitivity (IBH). Thus, it aids in better understanding the health and wellness of the Warmblood horse population, and the health treatments that could help such horses.

Cite This Article

APA
Kehrli D, Jandova V, Fey K, Jahn P, Gerber V. (2014). Multiple hypersensitivities including recurrent airway obstruction, insect bite hypersensitivity, and urticaria in 2 warmblood horse populations. J Vet Intern Med, 29(1), 320-326. https://doi.org/10.1111/jvim.12473

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 29
Issue: 1
Pages: 320-326

Researcher Affiliations

Kehrli, D
  • Swiss Institute of Equine Medicine, University of Berne and Agroscope, Berne, Switzerland.
Jandova, V
    Fey, K
      Jahn, P
        Gerber, V

          MeSH Terms

          • Animals
          • Data Collection
          • Europe / epidemiology
          • Female
          • Horse Diseases / epidemiology
          • Horse Diseases / immunology
          • Horses
          • Hypersensitivity / epidemiology
          • Hypersensitivity / immunology
          • Hypersensitivity / veterinary
          • Insect Bites and Stings / epidemiology
          • Insect Bites and Stings / immunology
          • Insect Bites and Stings / veterinary
          • Lung Diseases, Obstructive / epidemiology
          • Lung Diseases, Obstructive / veterinary
          • Male
          • Urticaria / epidemiology
          • Urticaria / immunology
          • Urticaria / veterinary

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