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The Veterinary clinics of North America. Equine practice2008; 24(1); 101-116; doi: 10.1016/j.cveq.2007.12.001

Multiple pathways to osteoarthritis and articular fractures: is subchondral bone the culprit?

Abstract: Osteoarthritis and articular fractures are commonly responsible for early retirement from athletic performance. The subchondral bone (SCB) in those conditions is being recognized as an integral component in their pathophysiology. Early recognition of these potentially career-ending diseases may require understanding of the progression of changes occurring in SCB with time and exercise.
Publication Date: 2008-03-04 PubMed ID: 18314038DOI: 10.1016/j.cveq.2007.12.001Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper focuses on the role of subchondral bone (SCB) in the development of osteoarthritis and articular fractures, which often result in the premature end of athletic careers. The researchers aim to gain an understanding of how changes in SCB over time and with exercise are tied to these diseases.

Purpose and Aim of the Study

  • The purpose of this study is to understand the role of subchondral bone (SCB) in the development of osteoarthritis and articular fractures among athletes.
  • The goal is to gain an understanding of how SCB changes with time and exercise leading to these potentially career-ending diseases.

Importance of the Study

  • Both osteoarthritis and articular fractures are among the leading causes of early retirement from athletic performance.
  • A better understanding of the pathophysiology of these conditions could lead to early detection and potentially preventative measures, prolonging the careers and improving the health of athletes.

Research Approach

  • The researchers likely engaged in an in-depth study of the SCB, investigating how its structural and physiological changes over time are connected to the development of osteoarthritis and articular fractures.
  • This may have involved the use of diagnostic imaging techniques, histological analysis, and biomechanical studies on various athletes, split into control and test groups based on their exposure to different levels of physical exercise and risk for osteoarthritis or articular fractures.

Findings and Future Studies

  • The abstract does not specify the study’s findings or conclusions, but they would likely include detailed observations regarding the impact of physical exercise on SCB and its role in triggering osteoarthritis and articular fractures.
  • Future research may well involve developing early detection methods and preventative treatment plans based on this study’s findings regarding the role of SCB in these diseases.

Cite This Article

APA
Cruz AM, Hurtig MB. (2008). Multiple pathways to osteoarthritis and articular fractures: is subchondral bone the culprit? Vet Clin North Am Equine Pract, 24(1), 101-116. https://doi.org/10.1016/j.cveq.2007.12.001

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 24
Issue: 1
Pages: 101-116

Researcher Affiliations

Cruz, Antonio M
  • Department of Clinical Studies, Comparative Orthopaedics Research Laboratory, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. acruz@uoguelph.ca
Hurtig, Mark B

    MeSH Terms

    • Animals
    • Biomechanical Phenomena
    • Bone Remodeling
    • Bone and Bones / injuries
    • Bone and Bones / pathology
    • Cartilage, Articular / injuries
    • Cartilage, Articular / pathology
    • Horse Diseases / etiology
    • Horse Diseases / pathology
    • Horses / injuries
    • Lameness, Animal
    • Osteoarthritis / etiology
    • Osteoarthritis / pathology
    • Osteoarthritis / veterinary
    • Tarsus, Animal / injuries
    • Tarsus, Animal / pathology

    Citations

    This article has been cited 6 times.
    1. Bagge J, Berg LC, Janes J, MacLeod JN. Donor age effects on in vitro chondrogenic and osteogenic differentiation performance of equine bone marrow- and adipose tissue-derived mesenchymal stromal cells. BMC Vet Res 2022 Nov 3;18(1):388.
      doi: 10.1186/s12917-022-03475-2pubmed: 36329434google scholar: lookup
    2. Bertoni L, Jacquet-Guibon S, Branly T, Desancé M, Legendre F, Melin M, Rivory P, Hartmann DJ, Schmutz A, Denoix JM, Demoor M, Audigié F, Galéra P. Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model. Int J Mol Sci 2021 Mar 2;22(5).
      doi: 10.3390/ijms22052499pubmed: 33801461google scholar: lookup
    3. Bertoni L, Jacquet-Guibon S, Branly T, Legendre F, Desancé M, Mespoulhes C, Melin M, Hartmann DJ, Schmutz A, Denoix JM, Galéra P, Demoor M, Audigié F. An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization. PLoS One 2020;15(6):e0235251.
      doi: 10.1371/journal.pone.0235251pubmed: 32584901google scholar: lookup
    4. McCarty CA, Thomason JJ, Gordon KD, Burkhart TA, Milner JS, Holdsworth DW. Finite-Element Analysis of Bone Stresses on Primary Impact in a Large-Animal Model: The Distal End of the Equine Third Metacarpal. PLoS One 2016;11(7):e0159541.
      doi: 10.1371/journal.pone.0159541pubmed: 27459189google scholar: lookup
    5. Smith AD, Morton AJ, Winter MD, Colahan PT, Ghivizzani S, Brown MP, Hernandez JA, Nickerson DM. MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS. Vet Radiol Ultrasound 2016 Sep;57(5):502-14.
      doi: 10.1111/vru.12369pubmed: 27198611google scholar: lookup
    6. Lin ST, Foote AK, Bolas NM, Peter VG, Pokora R, Patrick H, Sargan DR, Murray RC. Three-Dimensional Imaging and Histopathological Features of Third Metacarpal/Tarsal Parasagittal Groove and Proximal Phalanx Sagittal Groove Fissures in Thoroughbred Horses. Animals (Basel) 2023 Sep 14;13(18).
      doi: 10.3390/ani13182912pubmed: 37760312google scholar: lookup