Neutral solute transport across osteochondral interface: A finite element approach.
Abstract: Investigation of the solute transfer across articular cartilage and subchondral bone plate could nurture the understanding of the mechanisms of osteoarthritis (OA) progression. In the current study, we approached the transport of neutral solutes in human (slight OA) and equine (healthy) samples using both computed tomography and biphasic-solute finite element modeling. We developed a multi-zone biphasic-solute finite element model (FEM) accounting for the inhomogeneity of articular cartilage (superficial, middle and deep zones) and subchondral bone plate. Fitting the FEM model to the concentration-time curves of the cartilage and the equilibrium concentration of the subchondral plate/calcified cartilage enabled determination of the diffusion coefficients in the superficial, middle and deep zones of cartilage and subchondral plate. We found slightly higher diffusion coefficients for all zones in the human samples as compared to the equine samples. Generally the diffusion coefficient in the superficial zone of human samples was about 3-fold higher than the middle zone, the diffusion coefficient of the middle zone was 1.5-fold higher than that of the deep zone, and the diffusion coefficient of the deep zone was 1.5-fold higher than that of the subchondral plate/calcified cartilage. Those ratios for equine samples were 9, 2 and 1.5, respectively. Regardless of the species considered, there is a gradual decrease of the diffusion coefficient as one approaches the subchondral plate, whereas the rate of decrease is dependent on the type of species.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication Date: 2016-10-19 PubMed ID: 27793406DOI: 10.1016/j.jbiomech.2016.10.015Google Scholar: Lookup
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- Journal Article
Summary
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This research studied neutral solute transfer across the human and equine articular cartilage and subchondral bone plate, using both computed tomography and a mathematical modeling technique called biphasic-solute finite element modeling, to better understand the development of osteoarthritis. It found a slower solute diffusion rate as the substance approached the subchondral plate, and also found slight differences between the solute diffusion rates in human and equine samples.
Research Background and Methods
- The study aimed to improve understanding of osteoarthritis (OA) progression by examining how neutral solutes move across the articular cartilage and subchondral bone plate, structures that make up the osteochondral interface.
- The researchers used both computed tomography and biphasic-solute finite element modeling. Computed tomography provided visual imagery of the region, while finite element modeling allowed for numerical solutions of the solute transfer.
- The biphasic-solute finite element model (FEM) developed for this study accounted for the varying nature of the articular cartilage in the superficial, middle and deep zones, as well as the subchondral bone plate.
- Researchers determined the diffusion coefficients, a measure of solute movement, by fitting the FEM model to the concentration-time curves of the cartilage and the equilibrium concentration of the subchondral plate/calcified cartilage.
Research Findings
- The results showed slightly higher solute diffusion coefficients for all zones in the human samples as compared to the equine samples.
- In the human samples, the diffusion coefficient in the superficial zone was about three times higher than in the middle zone. The coefficient of the middle zone was 1.5 times higher than that of the deep zone, and the diffusion coefficient of the deep zone was 1.5 times higher than that of the subchondral plate/calcified cartilage.
- In the equine samples, the ratios between the zones were 9, 2 and 1.5, respectively.
- These results indicate a gradual decrease of the solute diffusion coefficient as it moves closer to the subchondral plate. However, the rate of decrease is dependent on the species, being slightly faster in equine samples than in human samples.
Cite This Article
APA
Arbabi V, Pouran B, Weinans H, Zadpoor AA.
(2016).
Neutral solute transport across osteochondral interface: A finite element approach.
J Biomech, 49(16), 3833-3839.
https://doi.org/10.1016/j.jbiomech.2016.10.015 Publication
Researcher Affiliations
- Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628CD Delft, The Netherlands; Department of Orthopedics, UMC Utrecht, Heidelberglaan100, 3584CX Utrecht, The Netherlands. Electronic address: v.arbabi@gmail.com.
- Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628CD Delft, The Netherlands; Department of Orthopedics, UMC Utrecht, Heidelberglaan100, 3584CX Utrecht, The Netherlands.
- Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628CD Delft, The Netherlands; Department of Orthopedics, UMC Utrecht, Heidelberglaan100, 3584CX Utrecht, The Netherlands; Department of Rheumatology, UMC Utrecht, Heidelberglaan100, 3584CX Utrecht, The Netherlands.
- Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628CD Delft, The Netherlands.
MeSH Terms
- Aged
- Aged, 80 and over
- Animals
- Cartilage, Articular / diagnostic imaging
- Cartilage, Articular / physiology
- Femur / diagnostic imaging
- Femur / physiology
- Finite Element Analysis
- Horses
- Humans
- Models, Biological
- Osteoarthritis / diagnostic imaging
- Osteoarthritis / physiopathology
- Tomography, X-Ray Computed
Citations
This article has been cited 4 times.- Qiao K, Chen Q, Cao Y, Li J, Xu G, Liu J, Cui X, Tian K, Zhang W. Diagnostic and Therapeutic Role of Extracellular Vesicles in Articular Cartilage Lesions and Degenerative Joint Diseases. Front Bioeng Biotechnol 2021;9:698614.
- Fan X, Wu X, Crawford R, Xiao Y, Prasadam I. Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development. Front Cell Dev Biol 2021;9:659654.
- Paakkari P, Inkinen SI, Honkanen MKM, Prakash M, Shaikh R, Nieminen MT, Grinstaff MW, Mäkelä JTA, Töyräs J, Honkanen JTJ. Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health. Sci Rep 2021 Mar 10;11(1):5556.
- Kovács B, Vajda E, Nagy EE. Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis. Int J Mol Sci 2019 Sep 19;20(18).
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