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Home / Equine Research Bank / Mem Inst Oswaldo Cruz / Neutralising antibodies for Mayaro virus in Pantanal, Brazil...
Memorias do Instituto Oswaldo Cruz2015; 110(1); 125-133; doi: 10.1590/0074-02760140383

Neutralising antibodies for Mayaro virus in Pantanal, Brazil.

Abstract: The Pantanal hosts diverse wildlife species and therefore is a hotspot for arbovirus studies in South America. A serosurvey for Mayaro virus (MAYV), eastern (EEEV), western (WEEV) and Venezuelan (VEEV) equine encephalitis viruses was conducted with 237 sheep, 87 free-ranging caimans and 748 equids, including 37 collected from a ranch where a neurologic disorder outbreak had been recently reported. Sera were tested for specific viral antibodies using plaque-reduction neutralisation test. From a total of 748 equids, of which 264 were immunised with vaccine composed of EEEV and WEEV and 484 had no history of immunisation, 10 (1.3%) were seropositive for MAYV and two (0.3%) for VEEV using criteria of a ≥ 4-fold antibody titre difference. Among the 484 equids without history of immunisation, 48 (9.9%) were seropositive for EEEV and four (0.8%) for WEEV using the same criteria. Among the sheep, five were sero- positive for equine encephalitis alphaviruses, with one (0.4%) for EEEV, one (0.4%) for WEEV and three (1.3%) for VEEV. Regarding free-ranging caimans, one (1.1%) and three (3.4%), respectively, had low titres for neutralising antibodies to VEEV and undetermined alphaviruses. The neurological disorder outbreak could not be linked to the alphaviruses tested. Our findings represent strong evidence that MAYV and all equine encephalitis alphaviruses circulated in the Pantanal.
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Publication Date: 2015-02-03 PubMed ID: 25742272PubMed Central: PMC4371226DOI: 10.1590/0074-02760140383Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examined the presence of neutralizing antibodies for various viruses, including the Mayaro virus, in different animal populations in the Pantanal region of Brazil. The results indicate that these viruses have indeed been circulating in the area.

Study Design and Participants

  • The researchers conducted a serosurvey, which is a test of blood serum from a group of individuals to determine the prevalence of an antibody against a specific virus.
  • The study involved 237 sheep, 87 free-ranging caimans (a type of reptile), and 748 equids (horses and related animals).
  • The equids were of special interest as some had been part of a ranch where a recent neurological disorder outbreak had occurred.

Methods

  • The sera were tested using a plaque-reduction neutralisation test, which measures the ability of an individual’s serum to prevent a virus from forming plaques, or visible structures in cell layers.
  • An animal was considered seropositive if it had a 4-fold or greater difference in antibody titres, which is a measure of how much antibody an organism has produced.

Results

  • Among the 748 equids, 10 (1.3%) were seropositive for the Mayaro virus and two (0.3%) for the Venezuelan equine encephalitis virus (VEEV).
  • Among the 484 equids without a history of immunisation, 48 (9.9%) were seropositive for the Eastern equine encephalitis virus (EEEV) and four (0.8%) for the Western equine encephalitis virus (WEEV).
  • From the sheep population, five were seropositive for equine encephalitis alphaviruses, with specific counts for each virus. Caimans also showed presence of antibodies to VEEV and other, undetermined alphaviruses.
  • However, the research was unable to connect the neurological disorder outbreak on the ranch to any of the alphaviruses under study.

Conclusions

  • The study provides strong evidence that the Mayaro virus, as well as all equine encephalitis alphaviruses tested, had circulated in the Pantanal region.
  • These findings have implications for public health and animal health in the region, as these viruses can be transmitted to humans and may cause diseases.

Cite This Article

APA
Pauvolid-Corrêa A, Juliano RS, Campos Z, Velez J, Nogueira RM, Komar N. (2015). Neutralising antibodies for Mayaro virus in Pantanal, Brazil. Mem Inst Oswaldo Cruz, 110(1), 125-133. https://doi.org/10.1590/0074-02760140383

Publication

Memorias do Instituto Oswaldo Cruz
ISSN: 1678-8060
NlmUniqueID: 7502619
Country: Brazil
Language: English
Volume: 110
Issue: 1
Pages: 125-133
PII: S0074-02762015000100125

Researcher Affiliations

Pauvolid-Corrêa, Alex
  • Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
Juliano, Raquel Soares
  • Embrapa Pantanal, Ministério da Agricultura Pecuária e Abastecimento, Corumbá, MS, Brasil.
Campos, Zilca
  • Embrapa Pantanal, Ministério da Agricultura Pecuária e Abastecimento, Corumbá, MS, Brasil.
Velez, Jason
  • Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Nogueira, Rita Maria Ribeiro
  • Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
Komar, Nicholas
  • Centers for Disease Control and Prevention, Fort Collins, CO, USA.

MeSH Terms

  • Age Factors
  • Alligators and Crocodiles / blood
  • Alligators and Crocodiles / immunology
  • Alphavirus / immunology
  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood
  • Brazil / epidemiology
  • Encephalitis Virus, Eastern Equine / immunology
  • Encephalitis Virus, Venezuelan Equine / immunology
  • Encephalitis Virus, Western Equine / immunology
  • Encephalomyelitis, Eastern Equine / epidemiology
  • Encephalomyelitis, Eastern Equine / veterinary
  • Encephalomyelitis, Venezuelan Equine / epidemiology
  • Encephalomyelitis, Venezuelan Equine / veterinary
  • Encephalomyelitis, Western Equine / epidemiology
  • Encephalomyelitis, Western Equine / veterinary
  • Horse Diseases / blood
  • Horse Diseases / immunology
  • Horse Diseases / prevention & control
  • Horses / blood
  • Horses / immunology
  • Neutralization Tests
  • Seroepidemiologic Studies
  • Sheep / blood
  • Sheep / immunology
  • Wetlands

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