New trends for osteoarthritis: Biomaterials, models and modeling.
Abstract: The burden of osteoarthritis (OA), one of the major causes of functional disabilities in humans and animals, continues to increase worldwide while no disease-modifying OA drugs (DMOADs) that either slow down or reverse disease progression have been made available. Here, we provide a brief overview of recent advances in: designing new OA drug delivery approaches, focusing on lubrication-based biomaterials and drug delivery systems, such as hydrogels, liposomes, dendrimers, micro- and nanoparticles; using either large (horse) or small (zebrafish) relevant animal models to evaluate new therapeutic strategies; and OA in vitro modeling, focusing on 3D (organoid) models of cartilage regarding the Replace, Reduce and Refine (3R) principle of animal experimentation.
Copyright © 2023 Elsevier Ltd. All rights reserved.
Publication Date: 2023-01-06 PubMed ID: 36623796DOI: 10.1016/j.drudis.2023.103488Google Scholar: Lookup
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Summary
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This research paper discusses recent advancements in treating osteoarthritis (OA), including new drug delivery methods, better animal models to test therapies, and the development of 3D in-vitro models for cartilage.
New OA Drug Delivery Approaches
- The researchers touch on several novel drug delivery systems being developed for OA. These include lubrication-based biomaterials, hydrogels, liposomes, dendrimers, and various types of particles. These substances can carry drugs directly to the site of the disease, improving treatment efficacy and possibly reducing side effects.
Animal Models for Evaluating Therapies
- The paper highlights the use of large and small animal models for testing OA therapeutic strategies. Horses have long been used in OA research due to their similar cartilage thickness and disease features to humans. Recently, zebrafish have gained popularity as a model due to their fast generation time and the ease of genetically manipulating them.
In-Vitro Modeling
- Lastly, the article delves into in-vitro modeling advancements, especially the use of 3D models of cartilage, also known as organoids. Such models offer a more realistic simulation of the human body compared to traditional 2D cell culture systems. They allow scientists to analyze the disease and potential treatments in a controlled environment, while reducing the number of animals used in experimentation, adhering to the 3R (Replace, Reduce, Refine) principle of animal experimentation.
Cite This Article
APA
Manivong S, Cullier A, Audigié F, Banquy X, Moldovan F, Demoor M, Roullin VG.
(2023).
New trends for osteoarthritis: Biomaterials, models and modeling.
Drug Discov Today, 28(3), 103488.
https://doi.org/10.1016/j.drudis.2023.103488 Publication
Researcher Affiliations
- Faculty of Pharmacy, Faculty of Dentistry, and CHU Sainte-Justine Research Centre, Université de Montréal, Montréal, QC, Canada.
- Normandie University, UNICAEN, BIOTARGEN, Caen, France.
- Center of Imaging and Research in Locomotor Affections on Equines, Veterinary School of Alfort, Goustranville, France.
- Faculty of Pharmacy, Faculty of Dentistry, and CHU Sainte-Justine Research Centre, Université de Montréal, Montréal, QC, Canada.
- Faculty of Pharmacy, Faculty of Dentistry, and CHU Sainte-Justine Research Centre, Université de Montréal, Montréal, QC, Canada.
- Normandie University, UNICAEN, BIOTARGEN, Caen, France. Electronic address: magali.demoor@unicaen.fr.
- Faculty of Pharmacy, Faculty of Dentistry, and CHU Sainte-Justine Research Centre, Université de Montréal, Montréal, QC, Canada. Electronic address: vg.roullin@umontreal.ca.
MeSH Terms
- Humans
- Animals
- Horses
- Zebrafish
- Osteoarthritis / drug therapy
- Drug Delivery Systems
Conflict of Interest Statement
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Citations
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