Nitric oxide, inducible nitric oxide synthase and inflammation in veterinary medicine.
Abstract: Inflammation is a process consisting of a complex of cytological and chemical reactions which occur in and around affected blood vessels and adjacent tissues in response to an injury caused by a physical, chemical or biological insult. Much work has been performed in the past several years investigating inducible nitric oxide synthase (NOS, EC 1.14.13.39) and nitric oxide in inflammation. This has resulted in a rapid increase in knowledge about iNOS and nitric oxide. Nitric oxide formation from inducible NOS is regulated by numerous inflammatory mediators, often with contradictory effects, depending upon the type and duration of the inflammatory insult. Equine medicine appears to have benefited the most from the increased interest in this small, inflammatory mediator. Most of the information on nitric oxide in traditional veterinary species has been produced using models or naturally occurring inflammatory diseases of this species.
Publication Date: 2003-04-01 PubMed ID: 12665111
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article explores the role of nitric oxide and inducible nitric oxide synthase in inflammation and their impacts in veterinary medicine. It highlights that knowledge expansion of these elements over the course of study has especially benefited equine medicine.
Role of Nitric Oxide and Inducible Nitric Oxide Synthase In Inflammation
- Inflammation is a series of cell and chemical reactions that occur in response to injury caused by physical, chemical, or biological factors.
- The research delves into the function of inducible nitric oxide synthase (NOS) and nitric oxide in this inflammatory response.
- Nitric oxide is produced from inducible NOS and its formation is influenced by various inflammatory mediators.
Impact of these findings
- The study’s implications demonstrate contradictory effects of nitric oxide depending on the nature and duration of the inflammatory insult, meaning, differing triggers and timelines of inflammation can yield different outcomes.
- This increase in understanding has especially made a significant impact in equine medicine.
Models And Diseases for Information
- The research is primarily based on models or naturally occurring inflammatory diseases in traditional veterinary species.
- This approach has enabled an understanding of how nitric oxide functions in different species, paving the way for more specialized veterinary treatments.
Cite This Article
APA
Hunter RP.
(2003).
Nitric oxide, inducible nitric oxide synthase and inflammation in veterinary medicine.
Anim Health Res Rev, 3(2), 119-133.
Publication
Researcher Affiliations
- Department of Anatomy and Physiology, Kansas State University, College of Veterinary Medicine, 129 Coles Hall, Manhattan, Kansas 66506-5802, USA. rhunter@vet.k-state.edu
MeSH Terms
- Animals
- Arginine / metabolism
- Cytochrome P-450 Enzyme System / metabolism
- Cytokines / biosynthesis
- Dinoprostone / metabolism
- Histamine / metabolism
- Inflammation / metabolism
- Inflammation / physiopathology
- Inflammation / veterinary
- Nitric Oxide / immunology
- Nitric Oxide / physiology
- Nitric Oxide Synthase / genetics
- Nitric Oxide Synthase / metabolism
- Nitric Oxide Synthase Type II
Citations
This article has been cited 4 times.- da Silva MC, Dos Santos VM, da Silva MVB, Prazeres TCMM, Cartágenes MDSS, Calzerra NTM, de Queiroz TM. Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension. Front Mol Biosci 2022;9:1032177.
- da Silva GM, da Silva MC, Nascimento DVG, Lima Silva EM, Gouvêa FFF, de França Lopes LG, Araújo AV, Ferraz Pereira KN, de Queiroz TM. Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors. Biology (Basel) 2021 Oct 14;10(10).
- Maekawa T, Hajishengallis G. Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. J Periodontal Res 2014 Dec;49(6):785-91.
- Niu XJ, Wang ZR, Wu SL, Geng ZM, Zhang YF, Qing XL. Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue. World J Gastroenterol 2004 Mar 1;10(5):725-8.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
