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Home / Equine Research Bank / Vet Clin North Am Equine Pract / NMDA receptor antagonists and pain: ketamine.
The Veterinary clinics of North America. Equine practice2010; 26(3); 565-578; doi: 10.1016/j.cveq.2010.07.009

NMDA receptor antagonists and pain: ketamine.

Abstract: N-Methyl-D-aspartate (NMDA) is a synthetic chemical binding molecule (ligand) that selectively binds to the "slow response" glutamate NMDA receptor (NMDAR). NMDARs are important for normal brain function and play a central role in learning, memory, and the development of central nervous system hyperactive states. Diverse chemicals belonging to various drug families have demonstrated NMDAR antagonistic effects. Ketamine has been shown to produce antihyperalgesic effects produced by incision and tissue or nerve damage, and has become popular in equine practice as an anesthetic and more recently as an analgesic for standing surgical procedures and the treatment of laminitis. This review focuses on the development of ketamine as an anesthetic and analgesic in horses.
Copyright © 2010 Elsevier Inc. All rights reserved.
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Publication Date: 2010-11-09 PubMed ID: 21056300DOI: 10.1016/j.cveq.2010.07.009Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article primarily discusses the use of NMDA receptor antagonist, Ketamine, as an anesthetic and analgesic in horses.

Overview of NMDA Receptors and Antagonists

  • The article begins with an explanation about N-Methyl-D-aspartate (NMDA), a synthetic chemical binding molecule. It specifically binds to the “slow response” glutamate NMDA receptor, which is essential for normal brain function.
  • These receptors play a crucial role in various functions of the brain such as learning, memory, and the development of hyperactive states within the central nervous system.
  • The research focuses on various chemicals from different drug families that have shown NMDA receptor antagonistic effects. In essence, these chemicals act as blockers for the NMDA receptors, inhibiting or reducing their activity.

Ketamine as a NMDA Receptor Antagonist

  • Ketamine, a drug most commonly used as an anaesthetic, has been demonstrated to act as an antagonist for NMDA receptors. When administered, it can result in antihyperalgesic effects, essentially reducing heightened sensitivity to pain.
  • These properties make it useful in medical procedures that involve incision, tissue damage or nerve damage, as it can effectively ease the pain or discomfort.

Ketamine use in Equine Practice

  • The major highlight of the research is the increasing popularity of Ketamine in equine practice, which refers to veterinary care for horses.
  • It is primarily used as an anesthetic and increasingly as an analgesic as the drug has proven to be effective for standing surgical procedures and treating laminitis, a painful condition affecting horses’ hooves.
  • The article concludes by emphasizing the development and increasing use of Ketamine as both an anesthetic and analgesic drug in the treatment of horses.

Cite This Article

APA
Muir WW. (2010). NMDA receptor antagonists and pain: ketamine. Vet Clin North Am Equine Pract, 26(3), 565-578. https://doi.org/10.1016/j.cveq.2010.07.009

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 26
Issue: 3
Pages: 565-578

Researcher Affiliations

Muir, William W
  • Equine Anesthesia and Analgesia Consulting Services, 338 West 7th Avenue, Columbus, OH 43201, USA. bill.muir@amcny.org

MeSH Terms

  • Animals
  • Excitatory Amino Acid Antagonists / pharmacology
  • Excitatory Amino Acid Antagonists / therapeutic use
  • Horse Diseases / drug therapy
  • Horses / metabolism
  • Ketamine / pharmacology
  • Ketamine / therapeutic use
  • Pain / drug therapy
  • Pain / veterinary
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / metabolism

Citations

This article has been cited 12 times.
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    doi: 10.1037/a0026773pubmed: 22250657google scholar: lookup
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