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Non-primate hepacivirus infection with apparent hepatitis in a horse – Short communication.
Abstract: Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown. This study reports the detection of natural NPHV infection in a horse with apparent hepatitis, liver damage and high-level viraemia. NPHV could be hepatotropic and associated with hepatitis in horses.
Publication Date: 2014-07-21 PubMed ID: 25038950DOI: 10.1556/AVet.2014.011Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This research article discusses a case of a horse infected with Non-Primate Hepacivirus (NPHV), a virus previously identified in dogs and horses, exhibiting signs of hepatitis and liver damage. The study suggests that NPHV could potentially cause hepatitis in horses.
Research Focus and Findings
- The primary focus of this research is on Non-Primate Hepacivirus (NPHV), a virus that is fundamentally part of the Flaviviridae family and has previously been identified in dogs and horses. The investigation concerns the disease’s associations and manifestations in these animals.
- This study brings to light an incidence of NPHV infection in a horse. Symptomatically, the horse displayed apparent signs of hepatitis and suffered liver damage, with a high-level viraemia also being detected.
- These observations led the researchers to conclude that NPHV could be potentially hepatotropic, meaning that it shows a propensity to affect the liver specifically. Consequently, there is a possible correlation between NPHV and the presence of hepatitis in horses.
Importance of the Study
- This study sheds new light on the potential dangers of the NPHV infection. While there was some knowledge about the virus existing in dogs and horses, this is the first time a direct link with apparent hepatitis and liver damage in a horse has been reported.
- Detecting high-level viraemia in the horse, in this case, suggests a severe viral infection in which the virus has rapidly multiplied in the horse’s blood.
- Understanding that NPHV could possibly be hepatotropic helps in formulating preventive measures to protect other animals from potential infection. It would also aid in developing comprehensive veterinary treatments for the disease.
Future Directions and Research
- This investigation opens avenues for further research into the NPHV’s pathogenic potential. Research should also identify the different factors influencing the virus’ effect on various animals.
- Additional studies could focus on determining the prevalence of NHPV infections and characterizing the viral mechanisms that contribute to its potential hepatotropism.
- There is also a need for continuous surveillance of NPHV in animal populations to better understand its epidemiological patterns, the breadth of animals it might affect, and the possible environmental and genetic factors playing into its propagation.
Cite This Article
APA
Reuter G, Maza N, Pankovics P, Boros A.
(2014).
Non-primate hepacivirus infection with apparent hepatitis in a horse – Short communication.
Acta Vet Hung, 62(3), 422-427.
https://doi.org/10.1556/AVet.2014.011 Publication
Researcher Affiliations
- u00c1NTSZ Regional Institute of State Public Health Service Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses Szabadsu00e1g u00fat 7 H-7623 Pu00e9cs Hungary.
- Government Office for Baranya County Directorate of Food Chain Safety and Animal Health Pu00e9cs Hungary.
- u00c1NTSZ Regional Institute of State Public Health Service Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses Szabadsu00e1g u00fat 7 H-7623 Pu00e9cs Hungary.
- u00c1NTSZ Regional Institute of State Public Health Service Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses Szabadsu00e1g u00fat 7 H-7623 Pu00e9cs Hungary.
Citations
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