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The Veterinary clinics of North America. Equine practice2025; 41(1); 95-110; doi: 10.1016/j.cveq.2024.11.002

Nonexertional Rhabdomyolysis.

Abstract: Although horses most commonly develop exertional rhabdomyolysis, there are numerous causes for nonexertional rhabdomyolysis (nonER) that pose a serious health threat to horses. Their etiologies can be broadly categorized as toxic, genetic, inflammatory/infectious, nutritional, and traumatic and a variety of diagnostic tests are available to discern among them. This study discusses causes of nonER as well as diagnostics and treatments that are specific to each etiology. General treatment of acute rhabdomyolysis is covered in detail in the study in this issue on sporadic and recurrent exertional rhabdomyolysis.
Publication Date: 2025-01-31 PubMed ID: 39893125DOI: 10.1016/j.cveq.2024.11.002Google Scholar: Lookup
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Summary

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This research article explores nonexertional rhabdomyolysis in horses, studying the various causes and suitable diagnostic tests and treatments for each category of etiology (cause).

Understanding Nonexertional Rhabdomyolysis

Nonexertional rhabdomyolysis (nonER) relates to a severe health condition in horses, different from the commonly found exertional rhabdomyolysis. This research article presents an in-depth study of this condition, looking into its various causes and offering specific diagnostic tests and treatments.

  • NonER typically occurs due to reasons unrelated to exercise or exertion, contrasting with exertional rhabdomyolysis.
  • The root causes of nonER can be toxic, genetic, inflammatory/infectious, nutritional, or traumatic.

Analyzing the Causes of NonER

This study breaks down and discusses the different causes of nonER in extensive detail, categorizing them broadly into the following:

  • Toxic causes involve exposure to harmful substances or chemicals.
  • Genetic causes refer to inherited conditions or mutations that can lead to nonER.
  • Inflammatory or infectious causes are ones where the body’s immune response or an invading pathogen triggers nonER.
  • Nutritional causes are due to deficiencies or excesses in diet that affect the horse’s overall health.
  • Traumatic causes involve physical damage, for example, from an injury, leading to nonER.

Diagnostics and Treatments

Given the variety of etiologies for nonER, the study explores diverse diagnostic tests available to differentiate each cause. Specific treatments for each category of cause are also discussed.

  • These diagnostics procedures aid in assessing key characteristics of a horse’s condition to identify the specific cause of the disease.
  • Treatments options have been outlined for each cause, catering to the specific requirements of the disease.
  • The general treatment for acute rhabdomyolysis, a condition closely related to nonER, is also addressed in detail in the article.

Cite This Article

APA
Valberg SJ. (2025). Nonexertional Rhabdomyolysis. Vet Clin North Am Equine Pract, 41(1), 95-110. https://doi.org/10.1016/j.cveq.2024.11.002

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 41
Issue: 1
Pages: 95-110

Researcher Affiliations

Valberg, Stephanie J
  • College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA. Electronic address: valbergs@msu.edu.

MeSH Terms

  • Rhabdomyolysis / veterinary
  • Rhabdomyolysis / etiology
  • Rhabdomyolysis / diagnosis
  • Rhabdomyolysis / therapy
  • Horses
  • Animals
  • Horse Diseases / diagnosis
  • Horse Diseases / etiology
  • Horse Diseases / therapy