Nosological study of Borna disease virus infection in race horses.
Abstract: To investigate the prevalence of diseases in the Borna disease virus (BDV) antibody positive race horses, we undertook seroepidemiological studies of BDV infection on 125 culled race horses in Hokkaido, Japan. The serological study disclosed the presence of antibodies only to BDV-p40 or -p24 in 19.2% (24/125) and 3.2% (4/125) of culled horses, respectively. Antibodies to both BDV-p40 and -p24 were found in 24.0% (30/125) of these horses. Of particular note was the finding that locomotorium disorders were detectable at a significantly higher rate in BDV antibody positive horses than that in the seronegative horses. These results imply that BDV infection may possibly contribute to an increase in the incidence rate of locomotorium disorders in race horses.
Publication Date: 2001-12-26 PubMed ID: 11750144DOI: 10.1016/s0378-1135(01)00446-1Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research article studies the prevalence of diseases in race horses infected by the Borna Disease Virus (BDV). It suggests that BDV infection could potentially increase the occurrence rate of locomotor disorders in race horses.
Overview of the Study
- This research was conducted to determine the prevalence of diseases among BDV antibody positive race horses. BDV is a neurotropic virus that has been known to cause neurological disorders in a variety of vertebrates, including horses.
- The study was carried out on 125 race horses that were culled in Hokkaido, Japan. A seroepidemiological study was conducted on these horses to identify the presence of the BDV virus.
Results of the Study
- The serological study revealed the presence of antibodies to BDV-p40 or BDV-p24 in 19.2% (24 out of 125) and 3.2% (4 out of 125) of the culled horses, respectively. These antibodies indicate the presence of BDV infection in these horses.
- Furthermore, antibodies to both BDV-p40 and BDV-p24 were found in 24.0% (30 out of 125) of the horses. This might suggest a more severe or advanced stage of the BDV infection.
- A crucial finding from this research was that locomotorium disorders or motor skill problems were detected at a significantly higher rate in BDV antibody positive horses than in those that were seronegative. This suggests a possible link between BDV infection and an increase in the incidence of locomotorium disorders.
Implications of the Study
- This study provides strong evidence that BDV infection could possibly contribute to an increase in the occurrence of locomotorium disorders in race horses. If accurate, this has significant implications for race horse health management and veterinary practices.
- The research also highlights the importance of BDV antibody tests as a predictor for possible locomotor disorders in horses. This can be incorporated into routine health checks to ensure early detection and effective management of BDV infection in horses.
Cite This Article
APA
Hagiwara K, Okamoto M, Kamitani W, Takamura S, Taniyama H, Tsunoda N, Tanaka H, Iwai H, Ikuta K.
(2001).
Nosological study of Borna disease virus infection in race horses.
Vet Microbiol, 84(4), 367-374.
https://doi.org/10.1016/s0378-1135(01)00446-1 Publication
Researcher Affiliations
- Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan. k-hagi@rakuno.ac.jp
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Borna Disease / epidemiology
- Borna Disease / physiopathology
- Borna Disease / virology
- Borna disease virus / genetics
- Borna disease virus / immunology
- Borna disease virus / isolation & purification
- Brain / virology
- Enzyme-Linked Immunosorbent Assay / veterinary
- Female
- Horse Diseases / epidemiology
- Horse Diseases / physiopathology
- Horse Diseases / virology
- Horses
- In Situ Hybridization / veterinary
- Japan / epidemiology
- Male
- Prevalence
- RNA, Viral / analysis
- Seroepidemiologic Studies
- Sports
Citations
This article has been cited 3 times.- Takino T, Okamura T, Ando T, Hagiwara K. Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection. BMC Vet Res 2016 Nov 14;12(1):253.
- Ando T, Takino T, Makita K, Tajima M, Koiwa M, Hagiwara K. Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. J Vet Med Sci 2016 Dec 1;78(11):1669-1672.
- Hagiwara K, Tsuge Y, Asakawa M, Kabaya H, Okamoto M, Miyasho T, Taniyama H, Ishihara C, de la Torre JC, Ikuta K. Borna disease virus RNA detected in Japanese macaques (Macaca fuscata). Primates 2008 Jan;49(1):57-64.
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