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The Veterinary clinics of North America. Equine practice1992; 8(3); 609-626; doi: 10.1016/s0749-0739(17)30444-3

Ocular neoplasia.

Abstract: Except for two neoplasms, notably SCC and sarcoid, ocular and periocular tumors are uncommon in horses. The practitioner must accurately determine the type of tumor by histopathology so appropriate treatment and a legitimate prognosis can be offered. The first attempt at treatment has the greatest chance to result in a cure; an aggressive treatment regimen therefore should be selected from the start.
Publication Date: 1992-12-01 PubMed ID: 1458332DOI: 10.1016/s0749-0739(17)30444-3Google Scholar: Lookup
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Summary

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This study focuses on the occurrence, diagnosis, and treatment of ocular and periocular tumors in horses, stressing the importance of accurate diagnosis for an effective treatment plan and prognosis.

Overview of the Research

  • The paper investigates ocular and periocular tumors in horses, with an emphasis on two specific cancer types; Squamous Cell Carcinoma (SCC) and Sarcoid, which are fairly common among horses. Beyond these two, ocular tumors are said to be uncommon in horses.
  • The researchers highlight the need for accurate identification of the type of tumor through histopathology – technique used by pathologists to study the appearance of tissues under the microscope for diagnostic purposes. This accurate identification informs and shapes the treatment approach and prognosis for the patient.
  • The study emphasizes that the first attempt at treatment is most likely to result in a cure. Therefore, it encourages the adoption of an aggressive treatment plan from the onset.

Highlights on Diagnosis and Treatment

  • In the diagnosis of these ocular neoplasms, histopathology is presented as a critical tool. The histopathological evidences give the health practitioner an accurate picture of the type of tumor they are dealing with. This risk-stratified diagnosis is crucial in determining the appropriate therapeutic modalities and outlining the prognosis of the disease.
  • The researchers emphasized that the first attempt at treatment greatly influences the outcome and stands the highest chance of resulting in a cure. With this, the study suggests an aggressive treatment plan from the beginning, rather than adopting a conservative or wait-and-see approach. This recommendation seems to be hinged on the belief that aggressive treatment reduces the chances of recurrence and improves overall prognosis.

Final Remarks and Contributions

  • Overall, this work underlines the importance of prompt, accurate diagnosis and early aggressive treatment in managing ocular and periocular tumors in horses. It provides insights for practitioners and contributes to the ongoing discourse on the best practices for addressing such health conditions in horses.

Cite This Article

APA
Dugan SJ. (1992). Ocular neoplasia. Vet Clin North Am Equine Pract, 8(3), 609-626. https://doi.org/10.1016/s0749-0739(17)30444-3

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 8
Issue: 3
Pages: 609-626

Researcher Affiliations

Dugan, S J
  • Animal Eye Specialists, Phoenix, Arizona.

MeSH Terms

  • Animals
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / therapy
  • Carcinoma, Squamous Cell / veterinary
  • Eye Neoplasms / diagnosis
  • Eye Neoplasms / therapy
  • Eye Neoplasms / veterinary
  • Eyelid Neoplasms / diagnosis
  • Eyelid Neoplasms / therapy
  • Eyelid Neoplasms / veterinary
  • Horse Diseases / diagnosis
  • Horse Diseases / therapy
  • Horses
  • Melanoma / diagnosis
  • Melanoma / therapy
  • Melanoma / veterinary
  • Nictitating Membrane
  • Orbital Neoplasms / diagnosis
  • Orbital Neoplasms / therapy
  • Orbital Neoplasms / veterinary
  • Papilloma / diagnosis
  • Papilloma / therapy
  • Papilloma / veterinary

Citations

This article has been cited 6 times.
  1. Biondi V, Passantino A, Pugliese M, Monti S, Sfacteria A, Di Pietro S. Conjunctival Inverted Papilloma Progressing to Carcinoma. First Report in Horse. Vet Sci 2021 Jun 10;8(6).
    doi: 10.3390/vetsci8060108pubmed: 34200940google scholar: lookup
  2. Levitt S, Osinchuk S, Sandmeyer L. Diagnostic Ophthalmology. Can Vet J 2020 Jul;61(7):789-791.
    pubmed: 32655166
  3. Singer-Berk MH, Knickelbein KE, Lounsberry ZT, Crausaz M, Vig S, Joshi N, Britton M, Settles ML, Reilly CM, Bentley E, Nunnery C, Dwyer A, Lassaline ME, Bellone RR. Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses. Int J Genomics 2019;2019:3610965.
    doi: 10.1155/2019/3610965pubmed: 31637255google scholar: lookup
  4. Baptiste KE, Grahn BH. Equine orbital neoplasia: a review of 10 cases (1983-1998). Can Vet J 2000 Apr;41(4):291-5.
    pubmed: 10769765
  5. Quatember H, Nell B, Richter B, Rigler D, Dolezal M, Sykora S, Wallner B. Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid. Animals (Basel) 2025 Mar 22;15(7).
    doi: 10.3390/ani15070911pubmed: 40218305google scholar: lookup
  6. Labelle AL, Gemensky Metzler AM, McMullen RJ Jr, Wiggans KT, Labelle P, Hamor RE. Equine intraocular melanocytic neoplasia. Can Vet J 2024 Oct;65(10):1048-1054.
    pubmed: 39355695