One percent sodium carboxymethylcellulose prevents experimentally induced abdominal adhesions in horses.
Abstract: To evaluate the efficacy of 1% sodium carboxymethylcellulose (SCMC) for prevention of experimentally induced abdominal adhesions in horses. Methods: Prospective, controlled, experimental study. Methods: Twelve healthy adult horses. Methods: The effect of 1% SCMC on adhesion formation was evaluated in 12 healthy horses by using an established model of serosal trauma to induce intraabdominal adhesions. After ventral median celiotomy, 2 separate areas of the jejunum were abraded, and three 2-0 chromic gut sutures were placed in each abraded area. Jejunal resection and end-to-end anastomosis was performed at 2 sites distant to the abrasion sites. In treated horses (n = 6), 2 L of 1% SCMC was applied to the intestine before and after intestinal manipulation. In control horses (n = 6), 2 L of saline solution were applied to the intestine before and after surgical manipulation. All horses were euthanatized 10 days after surgery, and the abdominal cavity was evaluated for adhesion formation. The frequency of intraabdominal adhesions between groups was compared with a chi-square test. Statistical significance was set at P <.05. Results: All control horses had intraabdominal adhesions. Fibrous adhesions were associated with both jejunal abrasion sites in 5 control horses. Fibrous adhesions were also associated with 1 or both jejunal anastomotic sites in 5 control horses. Only 1 treated horse developed adhesions at the jejunal abrasion sites, and no adhesions were present at the anastomotic sites in the treated horses. There were significantly fewer adhesions in the SCMC treatment group compared with the control group (P <.05). Conclusions: In this experimental model, application of 1% SCMC reduced the frequency of intraabdominal adhesions at areas of serosal abrasion and at jejunal anastomotic sites. Conclusions: In horses at an increased risk for developing intraabdominal adhesions after intestinal surgery, the use of 1% SCMC during celiotomy may decrease the frequency of adhesion formation.
Copyright 2001 by The American College of Veterinary Surgeons
Publication Date: 2001-05-08 PubMed ID: 11340553DOI: 10.1053/jvet.2001.17849Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The article presents research findings on the use of 1% sodium carboxymethylcellulose (SCMC) in horses to prevent abdominal adhesions following experimental-induced intraabdominal trauma.
Research Methodology
- The experimental study involved 12 healthy adult horses divided into two groups: the treatment group and the control group.
- A model of abdominal trauma was created to induce intraabdominal adhesions. This involved a midline abdominal surgery (celiotomy), during which two separate areas of the small intestine (jejunum) were abraded and three gut sutures inserted in each abraded area.
- To intensify the impact of the trauma, a segment of the jejunum was resected and then sutured back together (anastomosis) at two sites different from the original abrasion sites.
- In the treatment group, the intestines were treated with 2 liters of 1% SCMC both before and after the surgical manipulation. The control group, on the other hand, was treated with 2 liters of saline solution both pre-and post-surgery.
- All horses were euthanized 10 days after the surgery and their abdominal cavity analyzed for adhesion formation. The comparison between the two groups was done using a chi-square statistical test with a significance level set at P <.05.
Key Findings
- All horses in the control group developed intraabdominal adhesions, with fibrous adhesions associated with both the abrasion sites and anastomotic sites.
- Conversely, only one horse in the treatment group developed adhesions at the abrasion site and absolutely none at the anastomotic sites.
- There was a significant reduction in the frequency of adhesions in the SCMC treatment group compared to the control group (P <.05).
Conclusions
- The results demonstrated that 1% SCMC applied during celiotomy significantly reduced the occurrence of intraabdominal adhesions at the areas of serosal abrasion and at the jejunal anastomotic sites.
- Considering these findings, the study suggests that horses at risk of developing intraabdominal adhesions after intestinal surgery could benefit from the use of 1% SCMC during the surgery to decrease the chance of adhesion formation.
Cite This Article
APA
Hay WP, Mueller PO, Harmon B, Amoroso L.
(2001).
One percent sodium carboxymethylcellulose prevents experimentally induced abdominal adhesions in horses.
Vet Surg, 30(3), 223-227.
https://doi.org/10.1053/jvet.2001.17849 Publication
Researcher Affiliations
- Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
MeSH Terms
- Abdomen
- Abdominal Injuries / chemically induced
- Anastomosis, Surgical / veterinary
- Animals
- Carboxymethylcellulose Sodium / therapeutic use
- Disease Models, Animal
- Horse Diseases / prevention & control
- Horses
- Jejunal Diseases / prevention & control
- Jejunal Diseases / veterinary
- Jejunum / surgery
- Postoperative Complications / prevention & control
- Postoperative Complications / veterinary
- Prospective Studies
- Sutures
- Tissue Adhesions / prevention & control
- Tissue Adhesions / veterinary
- Treatment Outcome
Citations
This article has been cited 3 times.- Stewart AS, Schaaf CR, Luff JA, Freund JM, Becker TC, Tufts SR, Robertson JB, Gonzalez LM. HOPX(+) injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia. Am J Physiol Gastrointest Liver Physiol 2021 Nov 1;321(5):G588-G602.
- Alonso Jde M, Alves AL, Watanabe MJ, Rodrigues CA, Hussni CA. Peritoneal response to abdominal surgery: the role of equine abdominal adhesions and current prophylactic strategies. Vet Med Int 2014;2014:279730.
- Yelimlieş B, Alponat A, Cubukçu A, Kuru M, Oz S, Erçin C, Gönüllü N. Carboxymethylcellulose coated on visceral face of polypropylene mesh prevents adhesion without impairing wound healing in incisional hernia model in rats. Hernia 2003 Sep;7(3):130-3.
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