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Reproduction (Cambridge, England)2022; 163(4); 183-198; doi: 10.1530/REP-21-0351

Oocyte metabolic function, lipid composition, and developmental potential are altered by diet in older mares.

Abstract: Dietary supplementation is the most feasible method to improve oocyte function and developmental potential . During three experiments, oocytes were collected from maturing, dominant follicles of older mares to determine whether short-term dietary supplements can alter oocyte metabolic function, lipid composition, and developmental potential. Over approximately 8 weeks, control mares were fed hay (CON) or hay and grain products (COB). Treated mares received supplements designed for equine wellness and gastrointestinal health, flaxseed oil, and a proprietary blend of fatty acid and antioxidant support (reproductive support supplement (RSS)) intended to increase antioxidant activity and lipid oxidation. RSS was modified for individual experiments with additional antioxidants or altered concentrations of n-3 to n-6 fatty acids. Oocytes from mares supplemented with RSS when compared to COB had higher basal oxygen consumption, indicative of higher aerobic metabolism, and proportionately more aerobic to anaerobic metabolism. In the second experiment, oocytes collected from the same mares prior to (CON) and after approximately 8 weeks of RSS supplementation had significantly reduced oocyte lipid abundance. In the final experiment, COB was compared to RSS supplementation, including RSS modified to proportionately reduce n-3 fatty acids and increase n-6 fatty acids. The ability of sperm-injected oocytes to develop into blastocysts was higher for RSS, regardless of fatty acid content, than for COB. We demonstrated that short-term diet supplementation can directly affect oocyte function in older mares, resulting in oocytes with increased metabolic activity, reduced lipid content, and increased developmental potential.
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Publication Date: 2022-01-28 PubMed ID: 37379450PubMed Central: PMC8942336DOI: 10.1530/REP-21-0351Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • N.I.H.
  • Extramural
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper investigates the impact of dietary supplementation on the oocyte function and developmental potential of older mares. It demonstrates that short-term diet supplementation can influence the metabolic activities of oocytes, thus leading to decreased lipid content and enhanced developmental potential.

Overview of the Research

  • The study was conducted in three separate experiments with the main objective of examining whether dietary supplements can bring in changes to oocyte metabolic function, lipid composition, and developmental potential in older mares.
  • Oocytes, also known as egg cells, were collected from healthy, maturing follicles of these mares for the study.
  • Dietary control groups were fed hay only (CON) or hay mixed with grain products (COB), while the treatment groups received different supplementation, including those for equine wellness and gastrointestinal health, flaxseed oil, and a proprietary blend of fatty acid and antioxidant support termed as ‘Reproductive Support Supplement’ (RSS).

Findings from the Experiments

  • In the first experiment, it was observed that oocytes from mares that were supplemented with RSS exhibited higher basal oxygen consumption compared to those from mares that received COB. This indicated that these oocytes have higher aerobic metabolism and a higher proportion of aerobic to anaerobic metabolism.
  • The second experiment found that the lipid abundance in oocytes from the same mares decreased after 8 weeks of RSS supplementation. This suggests that RSS supplementation can significantly reduce oocyte lipid content.
  • In the final experiment, oocytes of mares receiving RSS supplement (including the ones with modified RSS) had a higher potential to develop into blastocysts than those on the COB diet, regardless of the fatty acid content in the diet.
  • This implies that RSS improves the developmental potential of oocytes, irrespective of the fatty acid content in it.

Significance and Implications of the Research

  • The study effectively demonstrates that even short-term dietary supplementation can significantly affect the function of the oocyte in older mares.
  • These alterations include increased metabolic activity, reduced lipid content, and increased developmental potential.
  • This research could open pathways for improving reproductive health and efficacy in older mares, and possibly extend to other species.

Cite This Article

APA
Catandi GD, LiPuma L, Obeidat YM, Maclellan LJ, Broeckling CD, Chen T, Chicco AJ, Carnevale EM. (2022). Oocyte metabolic function, lipid composition, and developmental potential are altered by diet in older mares. Reproduction, 163(4), 183-198. https://doi.org/10.1530/REP-21-0351

Publication

Reproduction (Cambridge, England)
ISSN: 1741-7899
NlmUniqueID: 100966036
Country: England
Language: English
Volume: 163
Issue: 4
Pages: 183-198

Researcher Affiliations

Catandi, Giovana D
  • Equine Reproduction Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
LiPuma, Lance
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Obeidat, Yusra M
  • Electronic Engineering Department, Hijjawi Faculty for Engineering Technology, Yarmouk University, Irbid, Jordan.
Maclellan, Lisa J
  • Equine Reproduction Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Broeckling, Corey D
  • Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, Colorado, USA.
Chen, Tom
  • Department of Electrical and Computer Engineering, Colorado State University, Fort Collins, Colorado, USA.
  • School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA.
Chicco, Adam J
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Carnevale, Elaine M
  • Equine Reproduction Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.

MeSH Terms

  • Horses
  • Animals
  • Female
  • Male
  • Semen
  • Oocytes
  • Diet / veterinary
  • Fatty Acids
  • Antioxidants
  • Fatty Acids, Omega-6

Grant Funding

  • R21 HD097601 / NICHD NIH HHS

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