Oral supplementation with Lithothamnion extract in horses subjected to oligofructose overload intake: effects on systemic inflammation and multiple organ function.
Abstract: Systemic inflammatory response syndrome (SIRS) is a common condition in horses with gastrointestinal disorders. If not prevented or controlled, SIRS promotes multiple organ dysfunctions that may culminate in serious disabilities or even death. The objective of this study was to evaluate the effects of Lithothamnion supplementation on systemic inflammatory response and organ function variables in horses undergoing oligofructose overload (OFO) intake. Twelve healthy horses were randomly divided into control and treated groups. The treated group received Lithothamnion (100 mg/kg bw PO BID) for 7 days before oligofructose intake (10 g/kg PO). Horses underwent clinical and laboratory evaluation immediately before and 6, 12, 18, and 24 h following administration of oligofructose. Parametric data were subjected to ANOVA in randomized blocks, followed by Tukey, and Student's t-tests for mean comparsions. Non-parametric data were analyzed by the Friedman, Dunn's, and Mann-Whitney tests (P < .05). Systemic inflammation and organ dysfunction was evident in both groups; however, these changes were milder and delayed in the treated group. Supplementation attenuated and delayed the tachycardia, tachypnea, leukocytosis, hyperproteinemia, hyperbilirubinemia, hyperalbuminemia and hyperglycemia in treated horses undergoing OFO. Furthermore, increases in packed cell volume, red blood cells, hemoglobin, globulin, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, indirect and direct bilirubin and creatinine were observed only in the control group, remaining unchanged in the treated group. These findings demonstrate the potential of oral supplementation with Lithothamnion to ameliorate systemic inflammation and organ dysfunction in horses at risk of acquiring gastrointestinal disorders.
Copyright © 2022. Published by Elsevier Inc.
Publication Date: 2022-07-16 PubMed ID: 35850436DOI: 10.1016/j.jevs.2022.104082Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Veterinary
- Research Support
- Non-U.S. Gov't
- Clinical Examination
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Dietary Supplements
- Disease Management
- Disease Treatment
- Equine Diseases
- Equine Health
- Equine Research
- Gastrointestinal Diseases
- Gastrointestinal Health
- Horses
- In Vivo
- Inflammation
- Laboratory Methods
- Oral Administration
- Veterinary Care
- Veterinary Medicine
- Veterinary Research
Summary
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This research focuses on the effects of Lithothamnion supplementation on horses exposed to an excessive intake of oligofructose. The study found that the supplement helped in reducing and postponing symptoms of systemic inflammation and organ dysfunction.
Objective and Methodology
- The primary objective of this scientific study was to understand whether Lithothamnion, a type of algae, could lower the systemic inflammatory response and improve organ functioning in horses that ingested too much oligofructose.
- The experiment consisted of two groups of healthy horses – a control group and a group treated with the Lithothamnion supplement. The treated group was given a daily dosage of Lithothamnion for seven days before consuming oligofructose.
- Every horse was evaluated clinically and in the lab before oligofructose intake, and at six-hour intervals thereafter for the following 24 hours.
- The researchers used various statistical tests to analyze the data collected, looking at parameter changes over the specified timeframe.
Findings
- Following the oligofructose intake, signs of systemic inflammation and organ dysfunction were seen in both groups. However, the horses that were given the Lithothamnion supplement displayed milder symptoms, and these symptoms also appeared at a later stage as compared to the control group.
- Tachycardia, tachypnea, an increase in white blood cells, hyperproteinemia, an excess of bilirubin and albumin, and a high glucose level were all less severe and delayed in the group treated with Lithothamnion.
- The study also observed an increase in packed cell volume, red blood cells, hemoglobin, globulin, enzymes AST, ALT, gamma-glutamyl transferase, indirect and direct bilirubin, and creatinine only in the control group. In the group treated with the supplement, these parameters stayed the same.
Conclusion
- Overall, the results of the study suggest that Lithothamnion supplement has the potential to help alleviate the symptoms of systemic inflammation and organ dysfunction in horses prone to developing gastrointestinal disorders, primarily due to excessive oligofructose intake.
Cite This Article
APA
Cota LO, Júnior OS, Oliveira APL, Paz CFR, Maróstica TP, Duarte PC, Leme FOP, Faleiros RR.
(2022).
Oral supplementation with Lithothamnion extract in horses subjected to oligofructose overload intake: effects on systemic inflammation and multiple organ function.
J Equine Vet Sci, 117, 104082.
https://doi.org/10.1016/j.jevs.2022.104082 Publication
Researcher Affiliations
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; MULTILAB, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- EQUINOVA Research Group, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; MULTILAB, Veterinary School of Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; National Council for Scientific and Technological Development - CNPq, Brasília, Distrito Federal, Brazil. Electronic address: faleirosufmg@gmail.com.
MeSH Terms
- Alanine Transaminase
- Animals
- Aspartate Aminotransferases
- Bilirubin
- Creatinine
- Dietary Supplements
- Horse Diseases / drug therapy
- Horses
- Humans
- Inflammation / drug therapy
- Inflammation / veterinary
- Multiple Organ Failure / veterinary
- Oligosaccharides
- Systemic Inflammatory Response Syndrome / drug therapy
- Systemic Inflammatory Response Syndrome / veterinary
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