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Home / Equine Research Bank / Histochemistry / Paneth cell degranulation and lysozyme secretion during acut...
Histochemistry1991; 95(5); 529-533; doi: 10.1007/BF00315751

Paneth cell degranulation and lysozyme secretion during acute equine alimentary laminitis.

Abstract: The equine Paneth cell response to a shift in the microbial balance of the intestinal tract was studied by inducing an acute episode of alimentary laminitis in 6 mature ponies. The normal bacterial population of the gut was modified by administration of a carbohydrate-rich ration. During acute laminitis a dramatic degranulation of the Paneth cells occurred in the intestinal glands throughout the duodenum, jejunum, and ileum. Bacteriocidal lysozyme, which was immunohistochemically identified as a component of the Paneth cell secretory granule, was evident in the glandular lumina and in degranulated Paneth cells. These results indicate that lysozyme is secreted by the equine Paneth cell in an apparent attempt to regulate the changing microbial population induced by carbohydrate overload of the gut. From these observations, it is suggested that the Paneth cell plays a role in the mucosal defense system of the equine intestinal tract.
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Publication Date: 1991-01-01 PubMed ID: 1869451DOI: 10.1007/BF00315751Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores how a horse’s Paneth cells, found in the intestines, react to a sudden change in gut bacteria balance, caused by a carbohydrate-heavy diet, resulting in a condition known as alimentary laminitis.

Objective of the Research

  • The objective of the study was to examine and understand the response of Paneth cells in horses to a change in the microbial balance of the intestinal tract, specifically in cases of acute alimentary laminitis, a painful condition of the horse’s hoof.

Research Method

  • The study was carried out on six mature ponies.
  • The ponies’ intestinal microbial balance was deliberately altered by providing them with a high-carbohydrate diet.
  • The effects of induced acute laminitis on the functioning and structure of Paneth cells in the equine gut were observed and studied.

Results of the Study

  • Quite remarkably, during the phase of acute laminitis, the Paneth cells in the ponies’ intestines underwent significant degranulation.
  • This process was observed in the intestinal glands throughout the duodenum, jejunum, and ileum.
  • The bactericidal substance, lysozyme, which fights harmful bacteria, was also found to have been released from the Paneth cells. This release of lysozyme was a response to the microbial imbalance in the intestines resulting from consuming a carbohydrate-rich diet.

Implications of the Research

  • The study suggests that the Paneth cells play an integral part in the defensive system of the horse’s intestinal mucosa.
  • They respond to changes in microbial populations by secreting lysozyme, which helps to regulate the microbial balance, thereby contributing to the animal’s overall intestinal health.

Conclusion

  • The study increases knowledge on the role and function of Paneth cells in equine gut health, particularly in conditions like acute alimentary laminitis. These findings could potentially serve to shape prevention and treatment strategies for such conditions in the future.

Cite This Article

APA
Masty J, Stradley RP. (1991). Paneth cell degranulation and lysozyme secretion during acute equine alimentary laminitis. Histochemistry, 95(5), 529-533. https://doi.org/10.1007/BF00315751

Publication

Histochemistry
ISSN: 0301-5564
NlmUniqueID: 0411300
Country: Germany
Language: English
Volume: 95
Issue: 5
Pages: 529-533

Researcher Affiliations

Masty, J
  • Department of Veterinary Anatomy and Cellular Biology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Stradley, R P

    MeSH Terms

    • Animals
    • Cell Degranulation
    • Cytoplasmic Granules / ultrastructure
    • Digestive System Diseases / enzymology
    • Digestive System Diseases / pathology
    • Digestive System Diseases / physiopathology
    • Digestive System Diseases / veterinary
    • Foot Diseases / veterinary
    • Hoof and Claw
    • Horse Diseases / enzymology
    • Horse Diseases / pathology
    • Horse Diseases / physiopathology
    • Horses
    • Intestinal Mucosa / enzymology
    • Intestinal Mucosa / pathology
    • Intestinal Mucosa / physiopathology
    • Intestine, Small / enzymology
    • Intestine, Small / pathology
    • Intestine, Small / physiopathology
    • Muramidase / metabolism

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    Citations

    This article has been cited 7 times.
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    2. Vásquez M, Lira B, Rodríguez J, Falcón N, Ocampo J, Nishida F, Barbeito C, Zanuzzi C. Characterization of paneth cells in alpacas (Vicugna pacos, Mammalia, Camelidae). Tissue Cell 2016 Aug;48(4):383-8.
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