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Home/Equine Research Bank/J Anim Sci Biotechnol/Paneth cells in farm animals: current status and future dire...
Journal of animal science and biotechnology2023; 14(1); 118; doi: 10.1186/s40104-023-00905-5

Paneth cells in farm animals: current status and future direction.

Abstract: A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation of intestinal microbiota and intestinal stem cells (ISCs). Although there has been a lot of studies and reviews on human and murine Paneth cells under intestinal homeostasis or disorders, little is known about Paneth cells in farm animals. Most farm animals possess Paneth cells in their small intestine, as identified by various staining methods, and Paneth cells of various livestock species exhibit noticeable differences in cell shape, granule number, and intestinal distribution. Paneth cells in farm animals and their antimicrobial peptides (AMPs) are susceptible to multiple factors such as dietary nutrients and intestinal infection. Thus, the comprehensive understanding of Paneth cells in different livestock species will contribute to the improvement of intestinal health. This review first summarizes the current status of Paneth cells in pig, cattle, sheep, horse, chicken and rabbit, and points out future directions for the investigation of Paneth cells in the reviewed animals.
© 2023. Chinese Association of Animal Science and Veterinary Medicine.
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Publication Date: 2023-08-15 PubMed ID: 37582766PubMed Central: PMC10426113DOI: 10.1186/s40104-023-00905-5Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is a review on the current knowledge about Paneth cells in farm animals, including their roles, characteristics, and factors that influence them, and the implications for the health of these animals.

Overview of Paneth Cells in Farm Animals

  • The review attempts to fill a gap in the understanding of Paneth cells in farm animals. While studies and reviews have focused on human and murine Paneth cells in the context of intestinal disorders, information is limited on these cells in farm animals despite their vital functions.
  • Paneth cells have been identified in the small intestines of most farm animals, and they show distinctive characteristics in terms of cell shape, number of granules, and distribution in the intestine, based on the species.

Roles and Functions of Paneth Cells

  • Paneth cells play crucial roles in the health of farm animals by regulating intestinal microbiota and intestinal stem cells (ISCs).
  • Through the secretion of antimicrobial peptides (AMPs), these cells are involved in the defense against hostile bacteria and contribute to maintaining a balanced gut microbiome.

Influence of Dietary Nutrients and Infections

  • The review found that multiple factors, including dietary nutrients and intestinal infections, can affect Paneth cells and their production of AMPs in farm animals.
  • Changes in Paneth cells’ functions due to these factors can potentially lead to disruptions in intestinal health, underscoring the need for a better understanding of these cells in livestock species.

Implication for Improving Intestinal Health

  • Comprehensive knowledge about Paneth cells in different livestock species is important for improving their intestinal health. The livestock sector could potentially benefit from strategies that protect and enhance the functions of these cells to maintain a healthy gut flora and foster growth and development.
  • The researchers have identified future research directions for further exploration of Paneth cells in farm animals, suggesting the need for more species-specific studies incorporating broader aspects including diet and disease.

Cite This Article

APA
Cui C, Li L, Wu L, Wang X, Zheng Y, Wang F, Wei H, Peng J. (2023). Paneth cells in farm animals: current status and future direction. J Anim Sci Biotechnol, 14(1), 118. https://doi.org/10.1186/s40104-023-00905-5

Publication

Journal of animal science and biotechnology
ISSN: 1674-9782
NlmUniqueID: 101581293
Country: England
Language: English
Volume: 14
Issue: 1
Pages: 118
PII: 118

Researcher Affiliations

Cui, Chenbin
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Li, Lindeng
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Wu, Lin
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Wang, Xinru
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Zheng, Yao
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Wang, Fangke
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Wei, Hongkui
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Peng, Jian
  • Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. pengjian@mail.hzau.edu.cn.
  • The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 400700, China. pengjian@mail.hzau.edu.cn.

Grant Funding

  • U22A20511 / the Joint Funds of the National Natural Science Foundation of China
  • CARS-36 / China Agriculture Research System

Conflict of Interest Statement

The authors declare that they have no competing interests.

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