Periocular sarcoid in a horse.
Abstract: A periocular nodular sarcoid of the right upper and lower eyelids was diagnosed in an 11-year-old Thoroughbred mare. Computed tomography scan revealed the extent of the tumor. The mass was surgically debulked under general anesthesia, and the affected periocular region was injected intralesionally with Bacillus of Calmette and Guerin (BCG). An emulsion of cell wall fractions was used, which has been modified to reduce the toxic and allergic effect, but retain the antitumor activity. In total, five injections were performed at 2-week intervals. At follow-up 7 months after the last BCG injection, the tumor was completely resolved. Two years after the last treatment, the horse remains tumor-free.
Publication Date: 2004-04-20 PubMed ID: 15091319DOI: 10.1111/j.1463-5224.2004.04027.xGoogle Scholar: Lookup
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Summary
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This study presents the treatment and complete recovery of an 11-year-old Thoroughbred mare diagnosed with a periocular nodular sarcoid, which was surgically and therapeutically treated using a non toxic Bacillus of Calmette and Guerin (BCG) emulsion.
Identification of the Condition
- The horse was diagnosed with a periocular nodular sarcoid located in the right upper and lower eyelids. This is a form of tumor often found in horses and can negatively affect the animal’s vision and appearance.
- A computed tomography scan was utilized to further reveal the extent of the tumor and determine the best mode of treatment.
Treatment Method
- The tumorous mass was surgically reduced while the horse was under general anesthesia, which involved removing as much of the tumor as possible while ensuring minimal harm to the animal.
- The affected periocular region was then treated with Bacillus of Calmette and Guerin (BCG), a type of bacterium used as a treatment for certain types of cancer. It was injected directly into the lesion.
- The BCG used had been modified into an emulsion of cell wall fractions to lessen any toxic and allergic effects, while still maintaining its ability to combat the tumor.
- Over the course of the treatment, the horse received a total of five injections at 2-week intervals.
Outcome and Follow Up
- Seven months after the last BCG injection, the sarcoid tumor was found to be completely resolved, showcasing the effectiveness of the treatment strategy.
- Two years after the last treatment, the Thoroughbred mare remained free from tumors, suggesting the longer-term success of this treatment approach.
Cite This Article
APA
Komáromy AM, Andrew SE, Brooks DE, Detrisac CJ, Gelatt KN.
(2004).
Periocular sarcoid in a horse.
Vet Ophthalmol, 7(3), 141-146.
https://doi.org/10.1111/j.1463-5224.2004.04027.x Publication
Researcher Affiliations
- Department of Small and Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA. komaromy@vet.upenn.edu
MeSH Terms
- Animals
- BCG Vaccine / administration & dosage
- Diagnosis, Differential
- Eyelid Neoplasms / diagnosis
- Eyelid Neoplasms / veterinary
- Female
- Horse Diseases / diagnosis
- Horse Diseases / diagnostic imaging
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
- Injections, Intralesional / veterinary
- Sarcoidosis / diagnosis
- Sarcoidosis / veterinary
- Tomography, X-Ray Computed / veterinary
Citations
This article has been cited 3 times.- Klećkowska-Nawrot J, Goździewska-Harłajczuk K, Kupczyńska M, Kaleta-Kuratewicz K, Kuropka P, Barszcz K. Anatomical, Histological and Histochemical Observations of the Eyelids and Orbital Glands in the Lowland Tapir (Tapirus terrestris Linnaeus, 1785) (Perissodactyla: Ceratomorpha). Animals (Basel) 2023 Jun 23;13(13).
- Jindra C, Hainisch EK, Brandt S. Immunotherapy of Equine Sarcoids-From Early Approaches to Innovative Vaccines. Vaccines (Basel) 2023 Mar 30;11(4).
- Vandeborne L, Pantziarka P, Van Nuffel AMT, Bouche G. Repurposing Infectious Diseases Vaccines Against Cancer. Front Oncol 2021;11:688755.
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