Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals.
Abstract: The antibody response in horses inoculated with 2 doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals (1 to 3 months) was evaluated with regard to the persistence of virus-neutralizing (VN) antibodies. The durations for which the geometric mean VN titers were maintained significantly higher than those before the first vaccination (P<0.05) were up to 5 months in horses that received the vaccination with a 1-month interval (n=17) and 7 months for those that received it with a 2-month (n=17) or 3-month interval (n=14 or 17). The vaccination program with the 2-month interval was the most effective in maintaining VN antibodies for a long duration with the smallest gap of antibody decline between the first and second vaccinations.
©2021 The Japanese Society of Equine Science.
Publication Date: 2021-09-06 PubMed ID: 34539211PubMed Central: PMC8437755DOI: 10.1294/jes.32.99Google Scholar: Lookup
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Summary
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This study examined the long-term effectiveness of two doses of a live equine herpesvirus type 1 vaccine given at different intervals. The research found that a two-month gap between doses best maintained virus-neutralizing antibodies in horses over time.
Objective of the Study
- The primary objective of the study was to evaluate the persistence of virus-neutralizing (VN) antibodies in horses that were inoculated with two doses of a live equine herpesvirus type 1 vaccine. These vaccinations were administered at various inter-dose intervals: 1 month, 2 months, or 3 months apart.
Methods Used
- The researchers analyzed the strength and longevity of the antibody response by assessing the geometric mean VN titers in the vaccinated horses.
- The geometric mean VN titers were used as a measure to gauge the levels of VN antibodies in the horses following vaccination.
Key Findings
- Results revealed that the VN antibody levels were significantly higher for up to 5 months in horses that received vaccinations at a 1-month interval.
- For horses that were vaccinated at a 2-month or 3-month interval, elevated levels of VN antibodies were preserved up to 7 months.
- Interestingly, the vaccination program with a 2-month interval between doses was most effective in maintaining persistently high levels of VN antibodies over time, and it boasted the smallest decline in antibody levels between the first and second doses.
Conclusion
- This research provides valuable insight into the optimal scheduling of equine herpesvirus type 1 vaccinations for achieving durable virus immunity in horses.
- The findings suggest that a 2-month interval between the first and second vaccination could offer the most advantageous long-term protection against the virus by ensuring the highest and most sustained levels of VN antibodies in the vaccinated horses.
Cite This Article
APA
Bannai H, Kambayashi Y, Tsujimura K, Nagashima T, Takebe N, Tominari M, Nemoto M, Ohta M.
(2021).
Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals.
J Equine Sci, 32(3), 99-102.
https://doi.org/10.1294/jes.32.99 Publication
Researcher Affiliations
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
- Hidaka Training and Research Center, Japan Racing Association, Hokkaido 057-0171, Japan.
- Hidaka Training and Research Center, Japan Racing Association, Hokkaido 057-0171, Japan.
- Hidaka Training and Research Center, Japan Racing Association, Hokkaido 057-0171, Japan.
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
- Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
References
This article includes 7 references
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