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Veterinary medicine and science2017; 3(4); 187-197; doi: 10.1002/vms3.70

Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse.

Abstract: The aims of this study were to assess the plasma concentrations of romifidine in horses after intravenous injection, to evaluate the red blood cell (RBC) partitioning of the anaesthetic drug, and to improve knowledge regarding its sedative effect in horses describing the pharmacokinetic model. Eight adult Standardbred horses received a single bolus of romifidine at a dosage of 100 g/kg. Blood samples (5 mL) were collected immediately before romifidine administration (), and at 2, 5, 10, 15, 20, 25, 30, 40, 50, 60, 75, 90, 105, 120, 150 and 180 min after injection. A sedation score was recorded at the same time. The romifidine concentrations in plasma and red blood cells were determined by high performance liquid chromatography (HPLC). The plasma and red blood cell concentrations were correlated with the sedation at each time point. Romifidine produced a satisfactory level of sedation in all animals. The sedation was detectable in all horses for up to 105 min. All the animals returned to normal without any behavioural changes at 180 min. The romifidine concentrations in the red blood cells were significantly higher ( < 0.01) at all time points than those in the plasma. The T was 148.67 ± 61.59 min and body clearance was 22.55 ± 6.67 mL/kg per min. The results showed that after a single bolus administration of romifidine, a partitioning in the RBCs was detected.
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Publication Date: 2017-07-20 PubMed ID: 29152313PubMed Central: PMC5677780DOI: 10.1002/vms3.70Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focused on analyzing the plasma concentrations of a sedative drug called romifidine in horses after it was intravenously injected. It also examined how romifidine is distributed in red blood cells and its effects on horses.

Research Aim and Methodology

  • The primary goal of this study was to examine the plasma concentrations of romifidine in horses after it was administered intravenously. The researchers also aimed to determine how romifidine distributes itself within blood cells.
  • A secondary purpose of this research was to gain a deeper understanding of romifidine’s sedative effects on horses.
  • The researchers administered a single dose of romifidine to eight adult Standardbred horses. They did this using a single bolus at a dosage of 100 g/kg.
  • Blood samples were taken at intervals before and after the administration of the drug. Consequentially, measurements of sedation levels were taken simultaneously.
  • The researchers determined the concentrations of romifidine in plasma and red blood cells using high-performance liquid chromatography (HPLC).

Findings

  • According to the test results, romifidine produced a satisfactory level of sedation in all horses under study.
  • The effect of the sedation was detectable in all horses up to 105 minutes after the drug was administered.
  • All horses returned to normal, with no signs of behavioral changes, by 180 minutes after the drug was administered.
  • The concentrations of romifidine in the red blood cells were significantly higher at all time points sampled when compared to those in the plasma.
  • The results showed that when a single bolus administration of romifidine is used, partitioning in red blood cells can be detected.

Conclusion

  • This study shed light on the pharmacokinetics of romifidine. Pharmacokinetics is the study of how drugs move through the body. This includes absorption, distribution, metabolism, and excretion.
  • The results of this study will be valuable in the clinical application of romifidine, an important sedative used in equine medicine. It can also inform dosage and administration recommendations for this veterinary medicine.

Cite This Article

APA
Romagnoli N, Al-Qudah KM, Armorini S, Lambertini C, Zaghini A, Spadari A, Roncada P. (2017). Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse. Vet Med Sci, 3(4), 187-197. https://doi.org/10.1002/vms3.70

Publication

Veterinary medicine and science
ISSN: 2053-1095
NlmUniqueID: 101678837
Country: England
Language: English
Volume: 3
Issue: 4
Pages: 187-197

Researcher Affiliations

Romagnoli, Noemi
  • Department of Veterinary Medical Sciences (UNI EN ISO 9001:2008)University of BolognaOzzano EmiliaItaly.
Al-Qudah, Khaled M
  • Department of Veterinary Clinical SciencesFaculty of Veterinary MedicineJordan University of Science and TechnologyIrbidJordan.
Armorini, Sara
  • Department of Veterinary Medical Sciences (UNI EN ISO 9001:2008)University of BolognaOzzano EmiliaItaly.
Lambertini, Carlotta
  • Department of Veterinary Medical Sciences (UNI EN ISO 9001:2008)University of BolognaOzzano EmiliaItaly.
Zaghini, Anna
  • Department of Veterinary Medical Sciences (UNI EN ISO 9001:2008)University of BolognaOzzano EmiliaItaly.
Spadari, Alessandro
  • Department of Veterinary Medical Sciences (UNI EN ISO 9001:2008)University of BolognaOzzano EmiliaItaly.
Roncada, Paola
  • Department of Veterinary Medical Sciences (UNI EN ISO 9001:2008)University of BolognaOzzano EmiliaItaly.

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Citations

This article has been cited 3 times.
  1. Zigmantaitė V, Jonušaitė E, Grigalevičiūtė R, Kučinskas A, Treinys R, Navalinskas A, Žvikas V, Jakštas V, Pudžiuvelytė L, Bernatonienė J, Mačianskienė R, Jurevičius J. Evaluation of the Cardiac Electrophysiological and Haemodynamic Effects of Elsholtzia ciliata Essential Oil on Swine. Pharmaceuticals (Basel) 2022 Aug 10;15(8).
    doi: 10.3390/ph15080982pubmed: 36015131google scholar: lookup
  2. Bardhi A, Barbarossa A, Joubert A, Gehring R, Lambertini C, Romagnoli N. The Suitability of Dried Blood Spot Sampling for Pharmacokinetic Studies in Veterinary Medicine. Vet Sci 2025 May 18;12(5).
    doi: 10.3390/vetsci12050488pubmed: 40431581google scholar: lookup
  3. Lambertini C, Boanini E, Casalini I, Spaccini F, Rinnovati R, Romagnoli N. Comparison of Ketamine/Diazepam and Tiletamine/Zolazepam Combinations for Anaesthesia Induction in Horses Undergoing Partial Intravenous Anaesthesia (PIVA): A Retrospective Clinical Study. Vet Sci 2024 Nov 30;11(12).
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