Pituitary-adrenal activity and opioid release in ponies during thiopentone/halothane anaesthesia.
Abstract: The effect of thiopentone/halothane anaesthesia on the release of endogenous opioid, adrenocorticotrophin, arginine vasopressin, cortisol and catecholamine was investigated in ponies. The contribution made by halothane itself was studied by maintaining six ponies with a constant 1.2 per cent end tidal halothane concentration and five with a concentration ranging between 0.8 and 1.2 per cent. Cardiorespiratory depression was more prolonged in the ponies receiving a constant 1.2 per cent end tidal halothane concentration than in those which received less halothane. Plasma lactate concentration increased and haematocrit decreased during halothane anaesthesia. The concentrations of met-enkephalin, dynorphin and catecholamines did not change and those of beta-endorphin, adrenocorticotrophin, arginine vasopressin and cortisol increased during halothane anaesthesia. Halothane appeared to be a major stimulus to pituitary adrenocortical activation because the adrenocortical secretion was proportional to the amount of halothane inhaled. Beta-endorphin increased proportionally more than adrenocorticotrophin and their plasma concentrations were not correlated, suggesting that they have independent secretion mechanisms.
Publication Date: 1995-01-01 PubMed ID: 7709057DOI: 10.1016/0034-5288(95)90085-3Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study investigates the impact of thiopentone/halothane anaesthesia on certain hormones and substances in ponies. It uncovered that halothane concentration is a significant factor for pituitary adrenocortical activation and some hormones increased more than others, suggesting independent secretion mechanisms.
Understanding the Research’s Objective
- The primary goal of this research was to analyze the impact of thiopentone/halothane anaesthesia on particular substances in ponies. These substances included endogenous opioids, adrenocorticotrophin, arginine vasopressin, cortisol and catecholamines.
Research Methodology
- The researchers maintained six ponies at a constant 1.2% end tidal halothane concentration and another five ponies with a concentration that varied between 0.8 and 1.2% to study the effect of different levels of halothane on its own.
- The effects on cardiovascular and respiratory function, lactate concentration and haematocrit levels were studied during the use of halothane anaesthesia.
Research Findings
- The study discovered that when compared with the ponies receiving less halothane, ponies receiving a constant 1.2% end tidal halothane concentration experienced a more prolonged depression of heart rate and breathing.
- Halothane anaesthesia resulted in an increase in plasma lactate concentration and a decrease in haematocrit value.
- While the levels of met-enkephalin, dynorphin, and catecholamines did not change, the amounts of beta-endorphin, adrenocorticotrophin, arginine vasopressin and cortisol increased during halothane anaesthesia.
- The adrenocortical secretion was found to be proportional to the amount of halothane inhaled, which suggests that halothane might play a significant role in stimulating pituitary adrenocortical activation.
- The research also uncovered that beta-endorphin increased proportionally more than adrenocorticotrophin, and their plasma concentrations were not correlated. This suggests that these hormones may be secreted via independent mechanisms.
Cite This Article
APA
Luna SP, Taylor PM.
(1995).
Pituitary-adrenal activity and opioid release in ponies during thiopentone/halothane anaesthesia.
Res Vet Sci, 58(1), 35-41.
https://doi.org/10.1016/0034-5288(95)90085-3 Publication
Researcher Affiliations
- Animal Health Trust, Newmarket, Suffolk.
MeSH Terms
- Analysis of Variance
- Anesthesia, General / veterinary
- Anesthetics, General / pharmacology
- Animals
- Dose-Response Relationship, Drug
- Halothane / pharmacology
- Hemodynamics / drug effects
- Horses / blood
- Horses / physiology
- Male
- Opioid Peptides / blood
- Opioid Peptides / metabolism
- Pituitary-Adrenal System / drug effects
- Respiration / drug effects
- Thiopental / pharmacology
Citations
This article has been cited 2 times.- Rendle DI, Duz M, Beech J, Parkin T, Durham AE. Investigation of single and paired measurements of adrenocorticotropic hormone for the diagnosis of pituitary pars intermedia dysfunction in horses. J Vet Intern Med 2015 Jan;29(1):355-61.
- Nóbrega Neto PI, Luna SP, Queiroz-Williams P, Mama KR, Steffey EP, Carregaro AB. Cardiorespiratory and antinociceptive effects of two different doses of lidocaine administered to horses during a constant intravenous infusion of xylazine and ketamine. BMC Vet Res 2013 Oct 9;9:199.
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