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Home / Equine Research Bank / Anim Sci J / PLAG1 and NCAPG-LCORL in livestock.
Animal science journal = Nihon chikusan Gakkaiho2015; 87(2); 159-167; doi: 10.1111/asj.12417

PLAG1 and NCAPG-LCORL in livestock.

Abstract: A recent progress on stature genetics has revealed simple genetic architecture in livestock animals in contrast to that in humans. PLAG1 and/or NCAPG-LCORL, both of which are known as a locus for adult human height, have been detected for association with body weight/height in cattle and horses, and for selective sweep in dogs and pigs. The findings indicate a significant impact of these loci on mammalian growth or body size and usefulness of the natural variants for selective breeding. However, association with an unfavorable trait, such as late puberty or risk for a neuropathic disease, was also reported for the respective loci, indicating an importance to discriminate between causality and association. Here I review the recent findings on quantitative trait loci (QTL) for stature in livestock animals, mainly focusing on the PLAG1 and NCAPG-LCORL loci. I also describe our recent efforts to identify the causative variation for the third major locus for carcass weight in Japanese Black cattle.
© 2015 The Authors. Animal Science Journal published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Society of Animal Science.
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Publication Date: 2015-08-11 PubMed ID: 26260584PubMed Central: PMC5042058DOI: 10.1111/asj.12417Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses how the PLAG1 and NCAPG-LCORL genes, known for affecting human height, are also significantly linked to animal body weight/height. The study emphasizes the significance of these genes on mammalian growth and their potential use in selective breeding. Other findings imply these genes might also be associated with certain negative traits, like late puberty or risk for neuropathic disease.

Overview of the Research

  • The study conducts an examination of PLAG1 and NCAPG-LCORL genes in livestock animals to understand their role in determining stature or body size.
  • The research is mitigated with the concept of stature genetics which happens to display a simpler genetic architecture in livestock than in humans.
  • These loci have also been detected to be associated with a selective sweep in dogs and pigs, indicating their extensive influence in the animal kingdom.

Significance of PLAG1 and NCAPG-LCORL

  • This research recognizes the impactful role of PLAG1 and NCAPG-LCORL genes in influencing the growth or body size of mammals.
  • These genetic markers can be used in controlled or selective breeding, which could have profound implications on animal agriculture and breeding strategies.
  • The genes may function as useful and natural variants for tailoring specific traits in livestock. For instance, aiming at producing livestock with big body size or weight for enhanced productivity.

Association with Unfavorable Traits

  • Alongside their beneficial implications for selective breeding, the researchers also draw attention to some potential negative correlations of these loci.
  • The PLAG1 and NCAPG-LCORL genes may be associated with late puberty in animals or raise the risk for a neuropathic disease. This denotes that associations alone cannot be understood as causality – intensive research is essential to draw conclusions around causality and understand the full impacts and functioning of these genes.

Quantitative Trait Loci (QTL)

  • The paper further reviews recent findings on quantitative trait loci (QTL) for stature in livestock animals. These loci may hold multiple genes which cumulatively can control a phenotype trait.
  • The research focuses mainly on PLAG1 and NCAPG-LCORL loci as their significance in stature trait and weight trait of livestock animals is validated again as per the observations.
  • The authors’ recent endeavors to identify the causative variation for the third major locus affecting carcass weight in Japanese Black cattle are also highlighted.

Cite This Article

APA
Takasuga A. (2015). PLAG1 and NCAPG-LCORL in livestock. Anim Sci J, 87(2), 159-167. https://doi.org/10.1111/asj.12417

Publication

Animal science journal = Nihon chikusan Gakkaiho
ISSN: 1740-0929
NlmUniqueID: 100956805
Country: Australia
Language: English
Volume: 87
Issue: 2
Pages: 159-167

Researcher Affiliations

Takasuga, Akiko
  • National Livestock Breeding Center, Fukushima, Japan.

MeSH Terms

  • Animals
  • Body Height / genetics
  • Body Size / genetics
  • Body Weight / genetics
  • Cell Cycle Proteins / genetics
  • DNA-Binding Proteins / genetics
  • Humans
  • Livestock / genetics
  • Livestock / growth & development
  • Quantitative Trait Loci / genetics

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