Plasma atrial natriuretic peptide concentration in warmblood horses with heart valve regurgitations.
Abstract: This study measured plasma atrial natriuretic peptide (ANP) concentration in horses with heart valve regurgitations (HVR) with and without atrial and ventricular dilatation. Background: In humans and small animals, plasma ANP concentration is increased in heart disease and correlates with the severity of clinical signs and heart enlargement. Methods: Ten healthy horses (control) and 36 horses with HVR were evaluated by auscultation, electrocardiography, echocardiography, and determination of plasma ANP. Results: Control horses demonstrated mean plasma ANP concentration of 21+/-5.4 pg/mL. Of the 36 horses with HVR, 17 horses possessed normal echocardiographic heart size (group 1), 10 horses had a left atrial dilatation (group 2) and 9 horses had both left atrial and ventricular dilatation (group 3). Mean plasma ANP concentration of groups 1, 2 and 3 was 20.1+/-5.6 pg/mL, 22.9+/-11.0 pg/mL and 27.6+/-17.4 pg/mL, respectively. The plasma ANP concentrations of HVR and control horses were not significantly different. The highest ANP concentrations were observed in horses with atrial and ventricular dilatation. No correlation between left atrial or ventricular size, weight, or sex and the plasma ANP concentration was found. Conclusions: No significant differences in plasma ANP concentration was observed between groups. Further study, especially in horses with clinical signs of heart failure is needed.
Publication Date: 2007-11-26 PubMed ID: 18032122DOI: 10.1016/j.jvc.2007.10.003Google Scholar: Lookup
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- Journal Article
- Atrial Function
- Cardiovascular Health
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Comparative Study
- Diagnosis
- Disease Diagnosis
- Disease Treatment
- Echocardiography
- Electrocardiography
- Equine Diseases
- Equine Health
- Equine Science
- Heart
- Heart Rate
- Horses
- Plasma
- Veterinary Medicine
- Veterinary Research
- Warmblood Horses
Summary
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The research investigates the concentration of plasma atrial natriuretic peptide (ANP) in horses with heart valve regurgitations (HVR), examining both horses with and without heart enlargement. The results showed no significant correlation between ANP concentration and heart size, weight, or sex in horses with HVR.
Research Background and Methodology
- The research background is based on knowledge gained from human and small animal studies where plasma ANP concentration increase was associated with heart disease, and the severity of clinical signs and heart enlargement.
- The study involved 10 healthy horses as controls and 36 horses suffering from HVR. They were examined through auscultation, electrocardiography, echocardiography, and plasma ANP determination.
Grouping and ANP Concentration Results
- The horses with HVR were divided into three groups based on the echocardiographic heart size. Group 1, consisting of 17 horses, had normal heart size. Group 2, comprising 10 horses, had left atrial dilatation, and Group 3, consisting of 9 horses, had both left atrial and ventricular dilatation.
- The control group of healthy horses showed a mean plasma ANP concentration of 21+/-5.4 pg/mL.
- The mean plasma ANP concentrations for the horses with HVR; Group 1, 2 and 3 were 20.1+/-5.6 pg/mL, 22.9+/-11.0 pg/mL and 27.6+/-17.4 pg/mL, respectively.
Correlation Findings and Conclusions
- The research did not establish a significant difference between the ANP concentrations in horses with HVR and the control group. Highest ANP concentrations were noted in horses with both left atrial and ventricular dilatation.
- The study also did not find a correlation between left atrial or ventricular size, weight, or sex, and the plasma ANP concentration.
- The Conclusion drawn from the study was that no significant differences existed in plasma ANP concentration between the groups.
- The researchers recommended further studies particularly on horses showing clinical signs of heart failure.
Cite This Article
APA
Gehlen H, Sundermann T, Rohn K, Stadler P.
(2007).
Plasma atrial natriuretic peptide concentration in warmblood horses with heart valve regurgitations.
J Vet Cardiol, 9(2), 99-101.
https://doi.org/10.1016/j.jvc.2007.10.003 Publication
Researcher Affiliations
- Equine Clinic, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. heidrun.gehlen@tiho-hannover.de
MeSH Terms
- Animals
- Aortic Valve Insufficiency / blood
- Aortic Valve Insufficiency / diagnostic imaging
- Aortic Valve Insufficiency / veterinary
- Atrial Natriuretic Factor / blood
- Case-Control Studies
- Echocardiography / methods
- Echocardiography / veterinary
- Electrocardiography / methods
- Electrocardiography / veterinary
- Female
- Horse Diseases / blood
- Horse Diseases / diagnostic imaging
- Horses / blood
- Male
- Mitral Valve Insufficiency / blood
- Mitral Valve Insufficiency / diagnostic imaging
- Mitral Valve Insufficiency / veterinary
- Severity of Illness Index
Citations
This article has been cited 1 times.- Gehlen H, Shety T, El-Zahar H, Hofheinz I. Measurement of plasma endothelin-1 concentration in healthy horses and horses with cardiac disease during rest and after exercise. J Vet Med Sci 2019 Feb 28;81(2):263-268.
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