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Veterinary research communications2007; 31(2); 185-195; doi: 10.1007/s11259-006-3385-2

Plasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy.

Abstract: Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to affect the anabolism of cartilage matrix molecules. A group of 30 Ardenner horses reared under standardized conditions from weaning were evaluated periodically from 15 to 28 months of age to detect the early manifestations of the disease. At the end of this period, horses were classified in two pathological groups related to the degree of interphalangeal degenerative osteoarthropathy based on clinical and radiographic evaluations: healthy (46.7%) and pathological (53.3%) horses. Seven sequential blood samples were taken from each horse (during the evaluation period) to study the variation of IGF-I plasma concentration. We tested the variations of the IGF-I plasma concentration during growth, and the effect of sex and of pathological classes. Significant variations were observed during the research period, with a maximum value corresponding to spring and a minimum in autumn. A significant reduction of the IGF-I plasma concentration was also observed in the pathological horses (433.5 +/- 19.5 ng/ml) compared to the healthy horses (493.9 +/- 18.2 ng/ml). An alteration in the level of this growth factor could induce a disregulation of the mechanisms involved in the local control of joint and bone tissue development.
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Publication Date: 2007-01-09 PubMed ID: 17216321DOI: 10.1007/s11259-006-3385-2Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the relationship between decreased levels of insulin-like growth factor I (IGF-I) in the blood and the development of degenerative joint disease in young Ardenner horses. The results indicate that a decrease in IGF-I levels could potentially disrupt the regulation of joint and bone tissue development, leading to degenerative osteoarthropathy.

Study Design and Sample

  • The sample for the study consisted of 30 Ardenner horses, all reared under standardized conditions from weaning.
  • The horses were evaluated periodically from the age of 15 to 28 months to detect early instances of degenerative osteoarthropathy.
  • These evaluations, which involved both clinical and radiographic assessments, resulted in horses being classified into two groups: healthy (46.7%) and pathological (53.3%).
  • Seven separate blood samples were taken from each horse over the evaluation period in order to study how the concentration of IGF-I in the plasma varied.

Results of the Study

  • Throughout the period of the study, there were significant fluctuations in the concentrations of IGF-I in the horses’ plasma, reaching maximum levels in spring and dipping to minimum levels in autumn.
  • The study found that horses classified as pathological had lower average concentrations of IGF-I (433.5 +/- 19.5 ng/ml) compared to horses that were classified as healthy (493.9 +/- 18.2 ng/ml).
  • The researchers concluded that alterations in the levels of this growth factor could lead to the disruption of mechanisms that control the development of joint and bone tissue.

Conclusions and Implications

  • The study demonstrated a notable correlation between lower IGF-I plasma concentrations in Ardenner horses and the occurrence of degenerative osteoarthropathy.
  • This could indicate that changes in IGF-I levels play a role in regulating joint and bone development, and that IGF-I deficiency may contribute to diseases of these tissues.
  • Further research is needed to fully understand this relationship, and to explore potential treatment options for degenerative osteoarthropathy that could involve the regulation of IGF-I levels.

Cite This Article

APA
Lejeune JP, Franck T, Gangl M, Schneider N, Michaux C, Deby-Dupont G, Serteyn D. (2007). Plasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy. Vet Res Commun, 31(2), 185-195. https://doi.org/10.1007/s11259-006-3385-2

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 31
Issue: 2
Pages: 185-195

Researcher Affiliations

Lejeune, J-Ph
  • Centre Européen du Cheval, Mont-le-Soie, Vielsalm. jph.lejeune@ulg.ac.be
Franck, T
    Gangl, M
      Schneider, N
        Michaux, C
          Deby-Dupont, G
            Serteyn, D

              MeSH Terms

              • Animals
              • Body Weight
              • Female
              • Horse Diseases / blood
              • Horse Diseases / diagnostic imaging
              • Horse Diseases / pathology
              • Horses
              • Insulin-Like Growth Factor I / metabolism
              • Joint Diseases / blood
              • Joint Diseases / diagnostic imaging
              • Joint Diseases / pathology
              • Joint Diseases / veterinary
              • Lameness, Animal / blood
              • Lameness, Animal / diagnostic imaging
              • Lameness, Animal / pathology
              • Least-Squares Analysis
              • Longitudinal Studies
              • Male
              • Radiography

              References

              This article includes 37 references
              1. Physiol Res. 2003;52(6):657-79
                pubmed: 14640888
              2. Biochem Biophys Res Commun. 1992 Dec 30;189(3):1255-60
                pubmed: 1282797
              3. Endocr Rev. 2003 Dec;24(6):782-801
                pubmed: 14671005
              4. J Orthop Res. 2001 Jan;19(1):26-32
                pubmed: 11332617
              5. Arch Biochem Biophys. 1988 Dec;267(2):416-25
                pubmed: 3214163
              6. J Anim Sci. 2003 Jun;81(6):1581-9
                pubmed: 12817507
              7. J Orthop Res. 2003 Sep;21(5):914-21
                pubmed: 12919881
              8. Endocrinology. 2001 Jan;142(1):165-73
                pubmed: 11145579
              9. J Anim Sci. 2003 Nov;81(11):2804-10
                pubmed: 14601884
              10. J Orthop Res. 2004 Jan;22(1):140-4
                pubmed: 14656672
              11. J Anim Sci. 1995 May;73(5):1424-32
                pubmed: 7665373
              12. Endocr Rev. 1989 Feb;10(1):68-91
                pubmed: 2666112
              13. Equine Vet J. 2003 May;35(3):302-7
                pubmed: 12755435
              14. Am J Vet Res. 2002 Feb;63(2):301-5
                pubmed: 11843134
              15. J Orthop Res. 2005 Jan;23(1):118-26
                pubmed: 15607883
              16. Equine Vet J. 2005 Jan;37(1):37-42
                pubmed: 15651732
              17. J Anim Sci. 1997 May;75(5):1351-8
                pubmed: 9159284
              18. J Reprod Fertil. 1990 Jan;88(1):167-76
                pubmed: 2107299
              19. J Reprod Fertil. 1990 Jan;88(1):185-95
                pubmed: 2107301
              20. Clin Orthop Relat Res. 2000 Oct;(379 Suppl):S201-13
                pubmed: 11039770
              21. Vet J. 2002 Jan;163(1):45-50
                pubmed: 11749135
              22. J Biol Chem. 2003 Sep 19;278(38):36563-71
                pubmed: 12853454
              23. J Anim Sci. 1996 Aug;74(8):1936-42
                pubmed: 8856448
              24. J Orthop Res. 2004 Mar;22(2):436-45
                pubmed: 15013107
              25. Osteoarthritis Cartilage. 2002 Aug;10(8):631-7
                pubmed: 12479385
              26. Am J Vet Res. 2003 Dec;64(12):1549-56
                pubmed: 14672435
              27. Gene Ther. 2002 Jan;9(1):12-20
                pubmed: 11850718
              28. Equine Vet J Suppl. 1999 Nov;(31):45-54
                pubmed: 10999660
              29. Theriogenology. 1998 Oct 1;50(5):727-37
                pubmed: 10734447
              30. Osteoarthritis Cartilage. 1998 Nov;6(6):374-6
                pubmed: 10343769
              31. Endocr Regul. 2001 Dec;35(4):201-8
                pubmed: 11858767
              32. Biol Reprod. 2002 Aug;67(2):648-54
                pubmed: 12135910
              33. Am J Physiol Cell Physiol. 2000 Oct;279(4):C961-9
                pubmed: 11003576
              34. J Anim Sci. 1995 Dec;73(12):3696-704
                pubmed: 8655446
              35. Cytokine. 2001 Oct 7;16(1):31-5
                pubmed: 11669584
              36. Matrix. 1991 Feb;11(1):17-24
                pubmed: 2027327
              37. J Bone Joint Surg Br. 2002 Mar;84(2):276-88
                pubmed: 11922373

              Citations

              This article has been cited 4 times.
              1. Fradinho MJ, Mateus L, Bernardes N, Bessa RJB, Caldeira RM, Ferreira-Dias G. Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study. PLoS One 2019;14(7):e0219900.
                doi: 10.1371/journal.pone.0219900pubmed: 31314780google scholar: lookup
              2. Baskerville CL, Bamford NJ, Harris PA, Bailey SR. Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse. Open Vet J 2017;7(1):75-80.
                doi: 10.4314/ovj.v7i1.12pubmed: 28540255google scholar: lookup
              3. Aguilar IN, Trippel SB, Shi S, Bonassar LJ. Comparison of Efficacy of Endogenous and Exogenous IGF-I in Stimulating Matrix Production in Neonatal and Mature Chondrocytes. Cartilage 2015 Oct;6(4):264-72.
                doi: 10.1177/1947603515578691pubmed: 26425264google scholar: lookup
              4. Verwilghen DR, Vanderheyden L, Franck T, Busoni V, Enzerink E, Gangl M, Lejeune JP, van Galen G, Grulke S, Serteyn D. Variations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions. Vet Res Commun 2009 Oct;33(7):701-9.
                doi: 10.1007/s11259-009-9219-2pubmed: 19319655google scholar: lookup
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