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Plasma concentrations of flunixin in the horse: its relationship to thromboxane B2 production.
Abstract: The effects of the intravenous (i.v.) administration of 1.1 mg/kg of flunixin meglumine on thromboxane B2 (TxB2) concentrations were studied in sedentary and 2-year-old horses in training. The baseline TxB2 serum concentrations generated during clotting were 2.89 +/- 0.81, 2.19 +/- 0.25 and 0.88 +/- 0.12 ng/ml for the 2-year-old Thoroughbreds in training, sedentary horses under 10 and over 10 years old, respectively. There was a significant difference in baseline TxB2 concentrations between older and younger horses (P less than 0.005). Significant reduction in TxB2 production from baseline were noted at 1 (P less than 0.01) and 4 h (P less than 0.01) but not at 8 h after flunixin administration. The percent reduction in serum TxB2 concentration at 1 h after the administration of flunixin was 68.6 +/- 7.3 and 45.2 +/- 6.8 for the training and sedentary horses, respectively; the differences were significant (P less than 0.04). Serum concentrations of TxB2 returned to baseline values by 12-16 h after flunixin administration. The results of this study indicate a difference in the TxB2 concentrations of older vs. younger horses and a difference in the suppression of TxB2 after the administration of flunixin in 2-year-old Thoroughbreds in training compared to sedentary horses. The results of this study suggest that the detection of low concentrations of flunixin in urine 24 h post-administration may not represent pharmacologic effective concentrations of flunixin in plasma.
Publication Date: 1992-09-01 PubMed ID: 1433493DOI: 10.1111/j.1365-2885.1992.tb01019.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study investigates the effects of the drug Flunixin on Thromboxane B2 (TxB2) concentrations in horses of different age groups and activity levels. The research found significant variances in TxB2 concentrations between older and younger horses and changes in TxB2 suppression based on different exercise levels after Flunixin administration.
Research Process
The study involved horses falling into two major categories; 2-year-old Thoroughbreds in training and sedentary horses under and over 10 years old. The drug Flunixin meglumine was intravenously administered with a dosage of 1.1 mg/kg.
For the study, the researchers kept track of various parameters including:
- The baseline TxB2 serum concentrations generated during clotting.
- The reduction in TxB2 production at different times after the administration of the drug Flunixin.
- The difference in the effect of Flunixin on the younger, thoroughly trained horses, and the older sedentary horses.
Findings
The researchers observed and reported the following findings:
- A significant difference in baseline TxB2 concentrations between the older and younger horses, indicating a correlation between age and TxB2 serum levels.
- A significant reduction was noted in TxB2 production from the baselines at 1 hour and 4 hours after the administration of Flunixin, but no significant change was reported at 8 hours. This suggests that the effect of the drug on TxB2 concentration wears off over time.
- In the case of younger Thoroughbreds under training, Flunixin caused a higher reduction of TxB2 concentration compared to sedentary horses.
Conclusion
The study indicates that there is a difference in the concentration of TxB2 produced in the blood of older versus younger horses and there is an observed variance between trained and sedentary horses after the administration of Flunixin.
The research also suggests that low concentrations of Flunixin detected in urine 24 hours after administration may not truly represent the pharmacologically effective concentrations of Flunixin in plasma. This information is significant for understanding flunixin’s usage and effectiveness in equine medicine.
Cite This Article
APA
Soma LR, Uboh CE, Rudy J, Fegely J.
(1992).
Plasma concentrations of flunixin in the horse: its relationship to thromboxane B2 production.
J Vet Pharmacol Ther, 15(3), 292-300.
https://doi.org/10.1111/j.1365-2885.1992.tb01019.x Publication
Researcher Affiliations
- Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
- Anti-Inflammatory Agents, Non-Steroidal / blood
- Clonixin / administration & dosage
- Clonixin / analogs & derivatives
- Clonixin / blood
- Horses / blood
- Injections, Intravenous / veterinary
- Leukocyte Count / veterinary
- Physical Conditioning, Animal
- Platelet Count / veterinary
- Thromboxane B2 / biosynthesis
- Thromboxane B2 / blood
Citations
This article has been cited 1 times.- Kuroda T, Minamijima Y, Nomura M, Yamashita S, Yamada M, Nagata S, Mita H, Tamura N, Fukuda K, Kuwano A, Kusano K, Toutain PL, Sato F. Medication control of flunixin in racing horses: Possible detection times using Monte Carlo simulations. Equine Vet J 2022 Sep;54(5):979-988.
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