Plasma elimination and urinary excretion of procaine after administration of different products to standardbred mares.
Abstract: Plasma and urinary concentrations of procaine were examined in Standardbred mares after subcutaneous administration of various doses (80 mg to 1600 mg) of procaine hydrochloride. Regardless of dose, peak plasma procaine values occurred within 1 h, but remained detectable in a dose-dependent manner, with procaine present at 1 h with the 80 mg dose and 6 h at the 1600 mg dose. Similarly, peak urinary procaine concentrations were attained within 1.5 to 3 h, irrespective of dose, while detection time was dose-dependent, being 23 h for 80-200 mg doses but as long as 30-54 h with the 1600 mg dose. When mares were given a single intramuscular injection of a penicillin G-procaine preparation (Ethacillin, Cillimycin, Penamycin, Derapen A, Azimycin or Diathal), peak plasma procaine concentrations varied and were reached from 10 min to 3 h in all cases, with detection from 3 to 20 h after drug administration. Although the peak urinary levels of procaine occurred between 30 mins and 6 h, detection in urine in most cases was as long as 78-120 h except for Diathal for which detection was limited to 54 h. Daily administration of a penicillin G-procaine preparation (Pen-Di-Strep) for 5 days produced a biphasic peak in plasma procaine at 3 and at 6-9 h with detection from 16 to 23 h after drug treatment. Although peak urinary procaine values were reached at similar times after single or multiple injections, the duration of detection was markedly longer (425 h) after the multiple-dose regimen.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1992-03-01 PubMed ID: 1582389DOI: 10.1111/j.2042-3306.1992.tb02795.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research examines the plasma and urinary concentrations of procaine in Standardbred mares following administration of various doses of procaine hydrochloride and assesses detection times after a single or multiple doses of a penicillin G-procaine preparation.
Procaine Hydrochloride
- The study measures plasma and urinary concentrations of procaine in Standardbred mares subsequent to the subcutaneous administration of differing doses of procaine hydrochloride, ranging from 80 mg to 1600 mg.
- Regardless of dosage, peak plasma procaine values occurred within 1 hour. However, the detectability was dependent on the specific dose. Procaine was noticeable at 1 hour with an 80 mg dose and 6 hours at the 1600 mg dose.
- Peak urinary procaine concentrations were attained within 1.5 to 3 hours, irrespective of dose. However, the duration of detection increased commensurate with dose. Detection times were 23 hours for 80-200 mg doses and as long as 30-54 hours with the 1600 mg dose.
Penicillin G-Procaine Preparation
- When the mares were given a single intramuscular injection of a penicillin G-procaine preparation such as Ethacillin, Cillimycin, Penamycin, Derapen A, Azimycin, or Diathal, each resulted in varied peak plasma procaine concentrations. These peaks occurred from 10 minutes to 3 hours in all cases.
- Notably, detection times also varied greatly, ranging from 3 to 20 hours after drug administration.
- Even though the peak urinary levels of procaine happened between 30 minutes and 6 hours, detection in urine, in most instances, was as long as 78-120 hours. However, for Diathal, detection was restricted to 54 hours.
Multiple Doses of Penicillin G-Procaine Preparation
- Administration of a penicillin G-procaine preparation (Pen-Di-Strep) for 5 consecutive days resulted in a biphasic peak in plasma procaine at 3 hours and again at 6-9 hours, with detection from 16 to 23 hours following the drug treatment.
- Whilst peak urinary procaine values were achieved at similar instances after single or multiple injections, the duration of detection was noticeably longer (425 hours) following the multiple-dose regimen.
Cite This Article
APA
Stevenson AJ, Weber MP, Todi F, Young L, Beaumier P, Kacew S.
(1992).
Plasma elimination and urinary excretion of procaine after administration of different products to standardbred mares.
Equine Vet J, 24(2), 118-124.
https://doi.org/10.1111/j.2042-3306.1992.tb02795.x Publication
Researcher Affiliations
- Race Track Division, Agriculture Canada, Ottawa.
MeSH Terms
- Animals
- Breeding
- Doping in Sports
- Dose-Response Relationship, Drug
- Female
- Horses / metabolism
- Injections, Intramuscular / veterinary
- Injections, Subcutaneous / veterinary
- Procaine / administration & dosage
- Procaine / blood
- Procaine / pharmacokinetics
- Procaine / urine
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