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Plasma [H+] regulation and whole blood [CO2] in exercising ponies.
Abstract: The major objective was to determine in ponies whether factors in addition to changes in blood PCO2 contribute to changes in plasma [H+] during submaximal exercise. Measurements were made to establish in vivo plasma [H+] at rest and during submaximal exercise, and CO2 titration of blood was completed for both in vitro and acute in vivo conditions. In 19 ponies arterial plasma [H+] was decreased from rest 4.5 neq/l (P less than 0.05) during the 7th min of treadmill running at 6 mph, 5% grade (P less than 0.5). A 5.6-Torr exercise hypocapnia accounted for approximately 2.9 neq/l of this reduced [H+]. The non-PCO2 component of this alkalosis was approximately neq/l, and it was due presumably to a 1.7-meq/l increase from rest in the plasma strong ion difference (SID). Despite the arterial hypocapnia, mixed venous PCO2 was 2.7 Torr above rest during steady-state exercise. Nevertheless, mixed venous plasma [H+] was 1.2 neq/l above rest during exercise, which was presumably due to the increase in SID. Also studied was the effect of submaximal exercise on whole blood CO2 content (CCO2). In vitro, at a given PCO2 there was minimal difference in CCO2 between rest and exercise blood, but plasma [HCO3-] was greater for exercise blood than for rest blood. In vivo, during steady-state exercise, arterial plasma blood. In vivo, during steady-state exercise, arterial plasma [HCO3-] was unchanged or slightly elevated from rest, but CaCO2 was 4 vol% below rest.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1990-01-01 PubMed ID: 2107165DOI: 10.1152/jappl.1990.68.1.309Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- U.S. Gov't
- Non-P.H.S.
- Research Support
- U.S. Gov't
- P.H.S.
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research investigates the effect of factors other than changes in blood PCO2 on plasma [H+] levels in ponies during submaximal exercise. By conducting various measurements during rest and exercise, scientists were able to identify changes in strong ion difference (SID) as a non-PCO2 contributing factor to changes in plasma [H+] levels. The study also explored the effect of exercise on whole blood CO2 content.
Objective and Methodology
- The primary aim of the research was to determine whether there are factors, apart from changes in blood PCO2, contributing to changes in plasma [H+] during submaximal exercise in ponies.
- The researchers took in vivo measurements of plasma [H+] at rest and during submaximal exercise, also performing CO2 titrations of blood under both in vitro and acute in vivo conditions.
Key Findings
- In the study group of 19 ponies, it was observed that arterial plasma [H+] decreased during the 7th minute of treadmill running at a graded pace of 6 mph.
- A minor exercise-related reduction in CO2 levels in the blood (hypocapnia) accounted for part of this reduced [H+]. There was a non-PCO2 component to the change as well, which was inferred to be due to an increase in the plasma strong ion difference (SID) from the rest levels.
- Even with the decreased arterial CO2 levels, the CO2 levels in sampled venous blood were slightly higher during steady-state exercise. This led to a slight increase in venous plasma [H+] during exercise, also attributed to the increased SID.
Additional Observations
- The study further measured the effect of submaximal exercise on the CO2 content (CCO2) of whole blood.
- In lab conditions (in vitro), plasma [HCO3-] was higher in exercise blood than rest blood at a given PCO2, but there was negligible difference in whole blood CO2 content between the two states.
- In vivo, the arterial plasma [HCO3-] remained largely unchanged or slightly elevated from rest during steady-state exercise, but the CaCO2 was observed to be lower than rest levels by 4 vol%.
Cite This Article
APA
Forster HV, Murphy CL, Brice AG, Pan LG, Lowry TF.
(1990).
Plasma [H+] regulation and whole blood [CO2] in exercising ponies.
J Appl Physiol (1985), 68(1), 309-315.
https://doi.org/10.1152/jappl.1990.68.1.309 Publication
Researcher Affiliations
- Medical College of Wisconsin, Milwaukee 53226.
MeSH Terms
- Acid-Base Equilibrium / physiology
- Animals
- Bicarbonates / blood
- Carbon Dioxide / blood
- Carotid Body / physiology
- Denervation
- Hemoglobins / analysis
- Horses / blood
- Hydrogen-Ion Concentration
- Physical Exertion / physiology
Grant Funding
- 25739 / PHS HHS
Citations
This article has been cited 1 times.- Lindinger MI, Waller AP. Physicochemical Analysis of Mixed Venous and Arterial Blood Acid-Base State in Horses at Core Temperature during and after Moderate-Intensity Exercise. Animals (Basel) 2022 Jul 22;12(15).
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