Platelet-rich plasma uterine infusion and pregnancy rate in barren mares with chronic degenerative endometritis.
Abstract: The chronic degenerative endometritis (CDE) is recognised as directly related to age and infertility in the mare. In this study, the 14 days post ovulation (PO) pregnancy rate was assessed in 60 barren mares affected by CDE, submitted to platelet-rich-plasma intrauterine infusion (PRPI) 24 hours PO. Data showed a significant positive effect of PRPI on the chance to become pregnant in mares affected by Kenney I-II CDE. The overall 14 days PO pregnancy rate was 75%. Sixty-nine % of the overall pregnancies was achieved with the 1st PRPI, but an additional 31% was obtained with the 2nd PRPI at the subsequent heat, increasing significantly the number of pregnancies. Although the 1st PRPI lead to a higher pregnancy rate than the 2nd PRPI (52 vs 23%), the repetition of the treatment had a significant positive effect on the overall pregnancies. Mare's young age positively influenced the chance to become pregnant and was associated to endometritis Kenney I. Mares with endometritis Kenney I had better chance to become pregnant than those with endometritis Kenney II. The PRPI proved, therefore, to be beneficial in barren mares with CDE, and resulted in high overall pregnancy rate achievement in barren mares.
Copyright© by the Polish Academy of Sciences.
Publication Date: 2020-10-03 PubMed ID: 33006855DOI: 10.24425/pjvs.2020.134688Google Scholar: Lookup
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- Clinical Trial
- Veterinary
- Journal Article
Summary
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This research investigates the effectiveness of platelet-rich plasma intrauterine infusion (PRPI) in increasing pregnancy rates for barren mares suffering from chronic degenerative endometritis (CDE). Results showed that PRPI was beneficial in improving pregnancy chances, particularly in younger mares and those with a less severe form of the condition (Kenney I).
Overview of Endometritis and Platelet-rich plasma intrauterine infusion (PRPI)
- Chronic degenerative endometritis (CDE) is a common condition in mares that has been directly related to aging and infertility.
- The study utilizes platelet-rich plasma intrauterine infusion (PRPI). This is a process that involves injecting platelet-rich plasma into the mare’s uterus, which aids in recovery and improves fertility.
Research Methodology
- The research was conducted on 60 barren mares suffering from CDE.
- PRPI was applied 24 hours post ovulation (PO) and the 14 days PO pregnancy rate was monitored.
- The researchers also considered the extent of the endometritis, categorized as Kenney I or Kenney II, which denote the level of severity of endometritis. Kenney I signifies less severe cases while Kenney II denotes more severe ones.
Key Findings
- Results showed a significant positive effect of PRPI treatment on the chances of pregnancy in mares affected by Kenney I-II CDE.
- The overall 14 days PO pregnancy rate after the application of PRPI was 75%.
- An interesting finding was that the first PRPI treatment led to a higher pregnancy rate (52%) than the second PRPI treatment (23%). This shows that the repetition of the treatment significantly improved overall pregnancies.
- Younger mares exhibited a higher chance of becoming pregnant and were often associated with Kenney I endometritis.
- On the other hand, mares with Kenney I endometritis had a better chance of becoming pregnant than those with Kenney II endometritis.
Conclusion
- The research concluded that PRPI treatment was beneficial for barren mares with CDE, leading to higher overall pregnancy rates.
Cite This Article
APA
Carluccio A, Veronesi MC, Plenteda D, Mazzatenta A.
(2020).
Platelet-rich plasma uterine infusion and pregnancy rate in barren mares with chronic degenerative endometritis.
Pol J Vet Sci, 23(3), 431-438.
https://doi.org/10.24425/pjvs.2020.134688 Publication
Researcher Affiliations
- Faculty of Veterinary Medicine, Veterinary Teaching Hospital University of Teramo, 64100 Teramo, Italy.
- Department of Veterinary Medicine, Università degli Studi di Milano, Via dell'Università 6, 26900, Lodi, Italy.
- Military Veterinary Center, Grosseto, Italy.
- Section of Physiology and Physiopathology, Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.
MeSH Terms
- Animals
- Chronic Disease
- Endometritis / therapy
- Endometritis / veterinary
- Female
- Horse Diseases / therapy
- Horses
- Platelet-Rich Plasma
- Pregnancy
- Pregnancy Rate
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