Polymorphism of Old Kladruber horses, a surviving but endangered baroque breed.
Abstract: Analysis of MHC class I and class II polymorphism, as well as data from other polymorphic systems (non-MHC lymphocyte alloantigen, blood groups systems, biochemical polymorphisms and microsatellite loci), was used to characterize the extent and distribution of the genic polymorphism of Kladruber horses. A breed-characteristic distribution of the MHC polymorphism was found. The repertoire of defined MHC class I specificities was restricted, especially in the grey subpopulation and in stallions, but a high frequency of blanks suggests the possible existence of undetected specificities. Despite the small population size and a relatively high degree of inbreeding, high heterozygosity in MHC haplotypes has been conserved. The extent of polymorphism and the degree of heterozygosity in other loci were also relatively high. A comparison of the two existing subpopulations, grey and black, at all the loci tested, including RAPD markers, characterized them as genetically distinct, although clearly related. The genetic distances between them were of the same order of magnitude as between distinct breeds. The results may be useful in defining short-term and long-term breeding policy within the breed and for further studies of associations with disease and other traits.
Publication Date: 1998-11-07 PubMed ID: 9805658DOI: 10.1046/j.1365-2370.1998.00117.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research is about the genetic variation identified in Old Kladruber horses, a rare breed, using different genetic markers. The findings highlight a unique breed-specific pattern of genetic diversity that has implications for future breeding programs, and may also help in studies related to disease resistance and other traits.
Understanding the Genic Polymorphism
- The researchers intensefully studied the genetic variation (polymorphism) in Old Kladruber horses, a breed that is both surviving and endangered.
- They analyzed polymorphism in Major Histocompatibility Complex (MHC) class I and class II along with other polymorphic systems including non-MHC lymphocyte alloantigen, blood groups systems, biochemical polymorphisms, and microsatellite loci.
- The MHC class I specificities were found to be restricted, particularly in the grey subpopulation and in stallions.
High Heterozygosity in Small Populations
- Interestingly, despite the small population size of these horses and a relatively high degree of inbreeding, high heterozygosity in MHC haplotypes has been conserved.
- This implies that a high level of genetic diversity has been maintained, which can be beneficial for a breed’s health and survival.
Polymorphism and Heterozygosity in Other Loci
- Apart from MHC, the degree of heterozygosity and polymorphism in other genetic locations (loci) were also found to be relatively high.
- This further underscores the preserved genetic diversity in the Old Kladruber horse breed.
Genetic Distinction between Subpopulations
- The two subpopulations within the breed, grey and black, were found to be genetically distinct, although clearly related.
- The genetic distances between them were similar to those observed between distinct horse breeds.
- This suggests that the different color varieties within the Old Kladruber breed have diverged significantly at the genetic level.
Implications for Breeding Programs and Other Studies
- This research has valuable implications for the breeding policies of Old Kladruber horses, suggesting the need for appropriate strategies to maintain genetic diversity.
- Additionally, it lays a foundation for future studies investigating associations between genetic variations and susceptibility to diseases and other health-related traits.
Cite This Article
APA
Horín P, Cothran EG, Trtková K, Marti E, Glasnák V, Henney P, Vyskocil M, Lazary S.
(1998).
Polymorphism of Old Kladruber horses, a surviving but endangered baroque breed.
Eur J Immunogenet, 25(5), 357-363.
https://doi.org/10.1046/j.1365-2370.1998.00117.x Publication
Researcher Affiliations
- Institute of Animal Breeding and Genetics, Faculty of Veterinary Medicine, Brno, Czech Republic.
MeSH Terms
- Animals
- Breeding
- Female
- Horses / genetics
- Major Histocompatibility Complex
- Male
- Microsatellite Repeats
- Polymorphism, Genetic
- Random Amplified Polymorphic DNA Technique
Citations
This article has been cited 2 times.- Sadeghi R, Moradi-Shahrbabak M, Miraei Ashtiani SR, Miller DC, Antczak DF. MHC haplotype diversity in Persian Arabian horses determined using polymorphic microsatellites.. Immunogenetics 2018 May;70(5):305-315.
- Janova E, Futas J, Klumplerova M, Putnova L, Vrtkova I, Vyskocil M, Frolkova P, Horin P. Genetic diversity and conservation in a small endangered horse population.. J Appl Genet 2013 Aug;54(3):285-92.
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