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Home / Equine Research Bank / Animals (Basel) / Polymorphisms at Myostatin Gene (MSTN) and the Associations ...
Animals : an open access journal from MDPI2021; 11(4); doi: 10.3390/ani11040964

Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses.

Abstract: One hundred and eighty Anglo-Arabian horses running 1239 races were sampled for the present study. DNA was extracted from the blood and myostatin gene, MSTN, was genotyped. Moreover, prizes won and places were achieved for the 1239 races to perform association analyses between the different genotypes and sport traits. Two SNPs already reported in previous studies regarding the Thoroughbred breed, rs69472472 and rs397152648, were revealed as polymorphic. The linkage disequilibrium analysis investigating the haplotype structure of MSTN did not evidence any association block. Polymorphism at SNP rs397152648, previously known as g.66493737 T>C, significantly influenced sport traits, with heterozygous horses TC showing better results than homozygotes TT. The portion of variance due to the random effect of the individual animal, and the other phenotypic effects of sex, percentage of Arabian blood and race distance, computed together with the genotype at MSTN in the statistical models, exerted a significant influence. Hence, this information is useful to improve knowledge of the genetic profile of Anglo-Arabian horses and a possible selection for better sport performance.
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Publication Date: 2021-03-30 PubMed ID: 33808485PubMed Central: PMC8065447DOI: 10.3390/ani11040964Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the relation between variations in the Myostatin gene (MSTN) and sporting performance in Anglo-Arabian racehorses, finding that certain genotypes are associated with better racing results.

Background and Objectives

  • The study aims to explore the correlation between single-nucleotide polymorphisms (SNPs) in the myostatin gene and racing performance in Anglo-Arabian horses. Myostatin is a protein that inhibits muscle differentiation and growth, so variations in this gene could potentially affect athleticism.
  • Previous studies had already identified two particular SNPs, rs69472472 and rs397152648, as being significant in Thoroughbred horses, and in this study, these SNPs were revealed to be polymorphic, meaning the gene occurred in several different forms.

Methods

  • 180 Anglo-Arabian horses who had run 1239 races were selected for the study. DNA was extracted from their blood and the relevant portion of the myostatin gene was genotyped.
  • In addition, performance data for these 1239 races, including prizes won and positions achieved, were used to perform association analyses between the different genotypes and sporting traits.

Findings

  • The analysis found no evidence of any association block within the haplotype structure of the myostatin gene, which suggested that each SNP could have an independent effect on muscle growth and hence athletic performance.
  • One of the SNPs, rs397152648, had a particularly strong influence on sport traits. Horses who were heterozygotes (TC) for this polymorphism achieve better results than their homozygous (TT) counterparts.
  • The study also found that the variance due to the random effect of the individual animal, as well as other phenotypic factors including sex, the percentage of Arabian blood, and race distance exerted significant influence on the results when combined with the genotype of the myostatin gene.

Implications

  • The findings are valuable for enhancing our understanding of the genetic profile of Anglo-Arabian horses, their sporting performance and potential breeding for improved athletic abilities.
  • The relationship between MSTN gene polymorphisms and athletic performance might also translate to other species and potentially human athletics.

Cite This Article

APA
Pira E, Vacca GM, Dettori ML, Piras G, Moro M, Paschino P, Pazzola M. (2021). Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses. Animals (Basel), 11(4). https://doi.org/10.3390/ani11040964

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 4

Researcher Affiliations

Pira, Emanuela
  • Local Health Authority 7 Pedemontana, Via dei Lotti 40, 36061 Bassano del Grappa, Italy.
Vacca, Giuseppe Massimo
  • Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Dettori, Maria Luisa
  • Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Piras, Gianpiera
  • Local Health Authority of Oristano, Via Carducci 35, 09170 Oristano, Italy.
Moro, Massimiliano
  • Local Health Authority of Nuoro, Via Amerigo Demurtas 1, 08110 Nuoro, Italy.
Paschino, Pietro
  • Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Pazzola, Michele
  • Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.

Grant Funding

  • Fondo di Ateneo per la ricerca 2020 / Fondo di Ateneo per la ricerca 2020, Università degli Studi di Sassari

Conflict of Interest Statement

The authors declare no conflict of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. This article is inspired by the data contained in the thesis by Emanuela Pira (Title of the thesis: Analisi dei polimorfismi del gene della miostatina (MSTN) e loro associazione con le performance del cavallo anglo arabo da corsa (in Italian language: Analysis of polymorphisms at myostatin gene (MSTN) and their association with Anglo-Arabian racehorse performance), PhD School in Veterinary Science, Department of Veterinary Medicine, University of Sassari, Italy, February 2017). The thesis is accessible as a hard copy at the library of the University of Sassari and as electronic file at the online library (http://eprints.uniss.it accessed on 20 January 2021), and it has not been published elsewhere.

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